A study found that a gene variation linked to obesity also affects food intake regulation by altering the expression of nearby genes. Reduced expression of these genes led to increased food intake and weight gain in mice.
A new grant will develop an innovative induction tomography system to assess the solidification process of metal, improving continuous casting of steel. This technology will detect defects in molten steel as it cools, enabling industry to monitor and alter the cooling process for better quality, safety, productivity, and competitiveness.
A team of researchers has identified an alternate mechanism for evading therapy in brain cancer cells, which adapts within as little as three days of treatment. By targeting both the original and new signaling pathways, they can durably suppress tumor growth.
A public repository of patient-derived cancer models has been established to share this technique widely. The Public Repository of Xenografts (PRoXe) contains biopsy tissue collected from patients with leukemia and lymphoma, allowing researchers worldwide to access the portal and create PDX models for testing drugs.
A study by the Johns Hopkins Bloomberg School of Public Health found that Maryland's 2011 increase in alcohol sales tax led to a 3.8% decrease in total alcohol sales. Sales of spirits were 5.1% lower, beer sales were 3.2% lower, and wine sales were 2.5% lower.
Research by Dr. Sven Joubert reveals that Alzheimer's disease affects holistic face perception, leading to difficulties in recognizing faces of family members or celebrities. This impairment is observed even in the early stages of the disease, highlighting potential strategies for patients to recognize their loved ones for longer.
A new study found that married patients with cancer fare better than unmarried ones, but the benefits vary by demographics. Unmarried individuals, particularly men, experience higher mortality rates compared to their married counterparts. The study also showed that birthplace and acculturation impact cancer survivorship.
A new study reveals that muscles controlling the eyes and eyelids are selectively spared in Duchenne muscular dystrophy due to higher utrophin levels. Researchers also found ECC machinery and calcium regulation similar to those of quadriceps muscles, challenging current understanding of muscle function.
A new low-cost approach uses 3D printing to create a knee model with femur, tibia, patella, and navigation system. The model simulates patella movement observed in cadaver models, enabling study of knee pain and impaired mobility.
A new hybrid drug combines parts of chloroquine and a chemoreversal agent to counteract malaria resistance. The dual-acting mechanism kills the parasite by concentrating the drug in its stomach.
Researchers have discovered over 1,000 new types of bacteria and Archaea, dramatically expanding the tree of life. The newly added organisms come from diverse environments and are characterized by their genome sequences, offering a new perspective on microbiology and its implications for our understanding of biology.
A global network is being set up to use surveillance camera networks and drone data to track changes in trees' growth patterns. Researchers will be able to access time-lapse image data to better understand how climate change affects forests worldwide.
Researchers at Massachusetts General Hospital identified subcapsular sinus macrophages that form a protective barrier around lymph nodes, blocking the spread of melanoma and other cancers. These SCS macrophages act as tumor suppressors but can be disrupted by cancer treatment drugs.
Researchers have discovered that e-cigarettes cause immediate damage to pulmonary function in healthy and mild asthmatic young smokers. The study, presented at CHEST World Congress 2016, found e-cigarette use led to worse airway obstruction and inflammation compared to cigarette smoking.
Researchers found that combining computed bioconductance (CB) with positron emission tomography (PET) before biopsy can improve the detection of potentially cancerous lung lesions. This non-invasive diagnostic tool may aid in the accurate evaluation of suspicious lung lesions.
A recent study highlights the need for sustainable shark conservation in Indonesia, where fin harvesting contributes to over 3 million shark deaths annually. Implementing no-fishing zones and providing alternative livelihood options can help protect shark populations and support local communities.
A new method has been developed by HKU astronomers to estimate more accurate distances between planetary nebulae and the Earth. The technique uses three sets of data, including object size, brightness, and dimming, to create a robust distance scale that can provide distances accurate to 20 percent.
Scientists have successfully extracted stem cells from a 50-year-old test subject's fatty tissue, applied genetic reprogramming, and produced mature, insulin-producing beta cells. The researchers' technique has the potential to treat diabetes by implanting new functional beta cells made from the patient's own adipose tissue.
A Lothian improvement project has seen a 13% increase in eligible women receiving food and vitamin vouchers compared to an 8% decline across Scotland. The scheme has also boosted family budgets by £4,500 on average.
A study found that traumatic childhood experiences have a profound impact on the mental health of healthcare professionals, causing them to think more deeply about life's meaning. The findings highlight the need for adequate support for clinicians in the aftermath of traumatic childbirth.
A new study finds a significant association between androgen deprivation therapy and depression in patients with localized prostate cancer. Patients treated with hormone therapy experienced higher incidences of depression, with risks increasing with treatment duration.
A father's family values can predict the family values held by Mexican-origin youth as well as the amount of time they spend with their families, according to new research. The study also found that parental acceptance and warmth play a crucial role in determining the link between family time and young adults' depressive symptoms.
New facilities will enable researchers to develop innovative therapeutic agents, models for managing fishery resources, and statistical models for analyzing aquatic habitats. This includes the creation of an aquatic habitat analysis and modelling laboratory and a facility for designing organometallic catalysts and therapeutics.
The Mid-Atlantic Regional Council on the Ocean hosted a regional workshop to discuss deepsea canyons ecosystem and existing management programs. Participants emphasized research, data sharing, outreach, and solutions to address pollution and climate change impacts on the canyons.
Researchers investigated how infants process others' actions and found that brain activity in the motor system predicts imitation of others' actions. The study provides evidence for intelligent social behavior in infants as young as 7 months old, shedding light on neural processes contributing to this complex behavior.
Thousands of islands face severe climate change impacts, including increased evaporation and freshwater scarcity. A new modeling approach shows that 73% of small islands will become more dry by mid-century, affecting 18 million people.
A quantitative study by the University of the Basque Country found that becoming unemployed alters people's moral values regarding fairness and redistribution. Most unemployed individuals tend to redistribute money equally among their group, regardless of whether it was earned or received through luck.
Researchers developed a novel method to measure mortality risk in elderly cancer patients with multiple diseases, providing a more accurate assessment than current survival rates. The approach uses machine learning and calculates the 'omega factor,' which compares a patient's cancer mortality risk to their overall mortality risk.
A clinical trial found that using PET imaging to guide chemotherapy significantly increases remission rates and reduces toxic side effects in advanced Hodgkin lymphoma patients. The study showed a promising approach to tailor treatment to individual patients, leading to a potential new standard of care.
Scientists at Simon Fraser University have developed a new method to exterminate rats by replicating the male brown rat's sex pheromone. This attracts female brown rats, allowing for effective trapping. The discovery forms part of a three-pronged rat control tactic that also exploits sound communication and food preferences.
Dr. Martinus van Genuchten has made significant contributions to soil physics and vadose zone hydrology, including developing theoretical equations that are now universally used worldwide. His leadership has also supported the careers of countless graduate students and junior scientists.
A review of 20 studies found little evidence that co-located primary care services can curb patient demand or improve emergency department throughput. In fact, set-up costs often outweigh marginal savings, and diverting patients to primary care may not be cost-effective.
The USPSTF recommends taking low-dose aspirin for primary prevention of cardiovascular disease and colorectal cancer in adults aged 50-69 years with increased risk. Aspirin use can outweigh harms for some patients, including those at high risk for CVD, improving life expectancy and quality of life.
A new study published in JAMA Neurology found that even prediabetes can cause nerve damage in people with small fiber neuropathy, challenging the conventional wisdom of how nerves deteriorate. The research showed that patients with prediabetes lost about 10% of their nerve fiber density each year, similar to those with diabetes.
A CHLA researcher has been awarded a four-year grant to study the development of cone photoreceptors in the retina, which can lead to devastating vision loss due to diseases like retinoblastoma. The goal is to improve modeling of these diseases and develop novel therapies using human embryonic stem cell-derived retina models.
Researchers have identified six newly discovered proteins that may help prevent diabetes, Alzheimer's disease, cancer, and other age-related illnesses. The tiny proteins are produced in the mitochondria of cells and play a significant role in metabolism and cell survival.
ATLAS project aims to break performance and cost barriers in inertial sensors using atomic frequency reference and MEMS Coriolis Gyroscope. The goal is to achieve robust GPS-independent navigation and guidance for the US military.
Patients with severe kidney stones admitted on weekends are 26% less likely to receive timely treatment, with nearly three times higher mortality rates compared to those treated early.
Researchers developed a system to enable robot or computer avatar interaction with patients playing the mirror game, promoting attachment and improving social coordination. The results show that players sharing similar movement features interact better, paving the way for social rehabilitation.
A study published in The Journal of Clinical Investigation identified a key role for S1 astrocytes in sustaining mechanical allodynia. Researchers found that specific signaling pathways activated in the brain contribute to neuropathic pain, suggesting new therapeutic targets.
Researchers analyzed over 7,000 patient encounters with severe sepsis or septic shock, finding that 68% of patients without shock did not receive an ICD diagnosis code. Patients assigned codes had a higher mortality rate, ICU admission rate, and hospital length of stay compared to those identified by clinical criteria alone.
A class of super-Earths with gaseous atmospheres is stripped away due to intense stellar radiation. This phenomenon occurs when planets lie close to their host stars, resulting in the loss of planetary 'envelopes', according to a new study.
NYU scholars presented research on diversity, inequality, and technology in education at the American Education Research Association (AERA) 2016 meeting. Preliminary findings indicate that 60% of public research universities have differential tuition, while nearly 30% of private research universities do. The studies also examine the im...
A UK-based clinical trial is being conducted to explore the effectiveness of a holistic rehabilitation program for people with and beyond cancer. The study aims to address the lack of support for those living with cancer in the UK, who often experience physical and emotional challenges after treatment.
Research estimates massive phosphorus buildup in landscapes, affecting aquatic ecosystems for decades. The study suggests strategies to recycle phosphorus and reduce its long-term impact on food and water security.
Researchers are reconstructing past temperature and hydrology records in southern Greenland using high-resolution quantitative methods. This project sheds light on climate variations during the period of Norse settlement, which had been abandoned by the early 15th century due to various factors.
Research by Brazilian scientists at D'Or Institute for Research and Education reveals Zika virus infection in human neural stem cells causes cell death, malformations, and reduced growth in neurospheres and brain organoids. The study highlights the etiological nature of microcephaly cases in Brazil.
A small study suggests Zika virus may be associated with an autoimmune disorder attacking the brain's myelin, similar to multiple sclerosis. Researchers found six people developed neurologic symptoms consistent with autoimmune disorders and underwent exams and blood tests, revealing signs of damage to the brain's white matter.
Researchers suggest that Neanderthals across Europe were infected with diseases carried out of Africa by waves of anatomically modern humans. This could have weakened the hunter-gathering Neanderthals and contributed to their extinction.
A large study found that fatty liver disease is common among liver transplant recipients, with a significant increase in prevalence over time. The condition is linked to various risk factors, including high body mass index, elevated blood triglycerides, and type 2 diabetes, but does not affect short-term patient survival.
Researchers found that exposure to cigarette smoke and flu viruses reduces the effectiveness of common COPD medication salbutamol. A new model could help identify alternative treatments for patients with these symptoms.
Geologists now track tectonic plate motion to understand ocean and mountain range formation, as well as animal species distribution. The technology reveals new geological relationships in Papua New Guinea and the Solomon Islands, with implications for predicting earthquakes and volcanic eruptions.
Researchers found that applying a magnetic field to PdCoO2, a non-magnetic metal, increases its electrical conductivity and reduces resistance. The phenomenon was linked to the material's layered crystal structure and topological characteristics.
A new lipid, LPA, has been found to regulate lymphocyte motility in narrow lymph nodes. LPA enables efficient movement through spaces jammed with immune cells and stromal cells. This discovery may lead to novel strategies for controlling immune responses.
A new Boston College study found that four leading teacher education rating systems lack evidence-based policies, questioning their validity. The researchers concluded that these accountability policies assume teachers are the primary solution to educational inequality, ignoring systemic societal inequalities.
A new analysis suggests that investing in basic healthcare services, including contraception and nutrition, can save up to 4.7 million lives annually at an average cost of $4.70 per person. The study found that these services could prevent half of all maternal, newborn, and child deaths.
Experts estimate that expanding proven interventions in pregnancy care, infectious disease treatment, and childhood nutrition could avert millions of maternal, newborn, and child deaths annually. The estimated investment required is approximately $6-12 billion per year, equivalent to just $4.7-$6.7 per person.
Researchers at Newcastle University have developed a DNA-based blood test that can detect liver scarring, also known as fibrosis, in patients with NAFLD. This breakthrough test measures epigenetic markers to stratify patients into mild or severe liver scarring, offering an early diagnosis and potentially improving patient outcomes.
The study reveals a new activation mechanism for protein kinase G I (PKG I), which may prevent unnecessary inhibition and enhance its activity. This discovery could lead to the design of drugs that target PKG I, providing new therapeutic options for diseases associated with PKG I dysfunction.
Aalto University researchers propose a standardised method for testing the wear and durability of superhydrophobic materials, including linear abrasion. They also emphasize the need to measure droplet mobility to assess the surface's robustness.