A team of scientists discovered a comprehensive set of suppressive mutations in yeast cells, which could help explain how some people remain healthy despite carrying catastrophic mutations. The findings provide new insights into the complex relationship between genetic suppression and disease-causing mutations.
Researchers suggest shifting from 'curing' Alzheimer's to building resilience, acknowledging the disease is intertwined with aging processes. They propose education, infrastructure support and proper care as key components of societal response.
Meari intensified from a tropical depression to a tropical storm in one day, now located 295 miles north of Yap and 500 miles west of Guam. Its maximum sustained winds are at 40 mph, and it is expected to turn west and northwest over the next few days.
Researchers have decoded the genome of Chinese licorice, a plant crucial in traditional Chinese medicine and natural sweetener. The study reveals the plant's genetic blueprint, which may facilitate the creation of sustainably bred strains with high glycyrrhizin content.
Researchers have discovered that distinct conformations of a protein essential for spliceosome assembly on mRNA precursors significantly influence splicing efficiency. The findings suggest that different structural configurations adopted by the large subunit of U2AF regulate splicing operations, affecting protein synthesis rates and fi...
Researchers have identified genetic markers associated with resistance to the antimalarial drug piperaquine, which could help track and contain outbreaks in Southeast Asia. The findings suggest that amplification of plasmepsin genes is linked to piperaquine resistance and may be used to identify patients at risk of treatment failure.
Researchers found a weak correlation between muscle size and strength gains following training. Muscle growth can occur with low or high load resistance training, but strength results vary.
Researchers compared the effectiveness of fMRI and polygraph tests in detecting deception, finding that fMRI outperformed polygraph with up to 90% accuracy. The study suggests that fMRI may be a valuable tool in criminal proceedings, particularly when used in sequence with polygraph.
A study published in Frontiers in Nutrition found that adopting a plant-based diet can significantly decrease the environmental impact and phosphorus footprint, with a potential reduction of 72% in phosphorus fertilizer requirements. This change has a moderate effect on reducing phosphorus excreted by the environment.
Research published in BMJ Open found that people with health anxiety were twice as likely to develop heart disease as those without it. The study, based on 7,052 participants, suggests that health anxiety can be a significant risk factor for coronary artery disease.
Researchers have developed a new metabolomics-based screening approach that can identify multiple different inborn errors of metabolism (IEMs) in a single urine sample. This method has the potential to detect numerous IEMs, which were previously detected in various bodily fluids such as blood and cerebrospinal fluid.
Researchers at the University of Edinburgh found that a drug called AT7519 helps restore normal function in neutrophils, which contribute to ARDS. The treatment approach shows promise for resolving inflammation in the lung and improving patient outcomes.
A large international study found that living in northerly climes is linked to an earlier age of starting MS symptoms. The study analyzed data from over 22,000 patients and found that each 10° increase in latitude was associated with a 10-month earlier onset.
A study published in the American Journal of Roentgenology found that radiologists who compare prior mammograms with more than one image have better true-positive outcomes and fewer false-positives. This reduction in recall rates can lead to a decrease in anxiety, radiation exposure, biopsies, and healthcare costs for patients.
A University of California, Irvine study found that beneficial gut microbes produce proteins called microcins, which help block illness-causing bacteria like salmonella and invasive E. coli in inflamed intestines. The researchers hope to develop targeted antibiotics based on these findings.
A study published by Durham University found that earworms, or songs that get stuck in your head, tend to have faster tempos, common melodic contours, and unusual interval structures. The researchers also identified specific songs with these characteristics, including Bad Romance and Don't Stop Believing.
New research suggests a novel mechanism by which HIV-1 may infect kidney epithelial cells lacking the major CD4 receptor. Transmembrane TNF-alpha is identified as a key player in this process, potentially facilitating the transmission of HIV-1 from mother to fetus.
Researchers at Oregon State University have identified another bacterium that can cause symptoms similar to salmon poisoning in dogs, complicating the problem. The new discovery makes it clear that dogs are not immune to salmon poisoning after a single infection and treatment.
Researchers developed a way to map environmental footprints to specific locations, connecting economic activity and global supply chains with environmental impacts. This innovation allows governments, companies, and individuals to identify areas where they can participate in reducing emissions and air pollution.
Scientists at EPFL and Nestéle Institute of Health Sciences identified 5000 proteins affected by the diurnal cycle in mouse liver cells. The study used cutting-edge proteomics to monitor protein accumulation over a 24-hour cycle, revealing key cellular functions such as DNA repair and ribosome biogenesis were also affected.
A new analysis reveals a direct correlation between carbon dioxide emissions and Arctic sea ice loss. The study suggests that reducing carbon emissions could slow the ongoing loss of summer ice and help achieve a 1.5°Celsius global warming target.
Scientists have found a key protein, connective tissue growth factor A (ctgfa), that facilitates spinal cord regeneration in zebrafish. The protein promotes the formation of bridges across damaged tissue, leading to improved healing outcomes.
A new study by CDC researchers reveals that American children are consuming excessive sodium levels, exceeding the daily recommended limit. The average sodium intake for kids was found to be 3,256 milligrams per day, with nearly 90% of children surveyed exceeding the upper level of recommended sodium intake.
The new 'smart' light-sheet microscope analyzes a specimen continuously and adjusts its settings to optimize image quality. Researchers achieved improvements in spatial resolution and signal strength by a factor of 2 to 5, making it easier to produce high-quality images of larger specimens.
Researchers found that rapidly increasing communication between subnetworks associated with visual information transformation into motor responses facilitates task automatization. The default mode network is decoupled from task-related networks as resources are released for controlled implementation.
The KBED program has helped attract or retain 16 companies in Manhattan and estimate an economic impact of $32.5 million in the area. The partnership also created 394 full-time jobs generating $19.1 million in annual salaries.
A recent study found that injury in schistosome parasites triggers stem cell growth, which restores aging tissue and aids the parasite's long-term survival. This discovery could lead to new ways to target these worms and improve our understanding of their infection mechanisms.
A University of Montreal professor studied reactions to virtual reality and an immersive projection system, finding that viewers preferred the shared experience without headsets.
A team of researchers at UC San Diego School of Medicine successfully reversed diabetic insulin resistance and glucose intolerance in mouse models by removing the protein galectin-3 (Gal3). This finding suggests that Gal3 inhibition could be an effective way to treat type 2 diabetes.
Research on non-native cycad herbivores reveals significant changes in leaf chemistry following herbivory, which can lead to faster litter decomposition and altered nutrient turnover rates. The study highlights the devastating consequences of invasive species on native ecosystems.
Researchers identified distinct mutational signatures associated with tobacco smoke, including Signature 4 and Signature 5. These signatures are linked to specific types of cancer, such as lung and larynx cancers, and may be driven by a cytidine deaminase enzyme or other unknown mechanisms.
Research from Binghamton University finds that pupil dilation in response to negative emotional faces predicts risk for depression relapse among women with a history of major depressive disorder. High or low reactivity to angry faces is associated with increased risk, while low reactivity to sad faces may be protective.
A new training initiative by the Houston Police Department is being tested for its effectiveness in reducing gender bias in police responses to sexual assault and domestic violence victims. The study, led by Sam Houston State University researchers, aims to improve the investigation and prosecution of these crimes.
Scientists discovered genetic markers linked with piperaquine resistance in Plasmodium parasites, allowing health officials to monitor the spread of resistance and guide treatment decisions. The emergence of piperaquine resistance in Cambodia threatens global efforts to eliminate malaria.
A study published in NeuroImage found that brain activation patterns are the same when decoding sentences in English and Portuguese. The research team developed a machine-learning algorithm to recognize sentence meaning in Portuguese based on neural activation patterns learned from English, achieving 67% accuracy.
A new Oxford University study found that internet gaming is not as addictive as gambling, with only 2-3% of gamers reporting symptoms of internet gaming disorder. The study suggests that while gamers may experience negative effects, they are not as severe as those experienced by gamblers.
Researchers from HSE Neurolinguistics Laboratory presented their work expanding Alexander Luria's neuroanatomical model of semantic aphasia by adding white matter tracts to it, which connect various regions of the cortex.
The WSU study reveals a non-invasive testing method, Trophoblast Retrieval and Isolation from the Cervix (TRIC), that offers accuracy similar to invasive tests like amniocentesis. TRIC can be performed five to 10 weeks earlier than current testing modalities and has the potential to identify pregnancies at risk for complications.
Scientists developed two types of llama antibody that can specifically mark and show amyloid plaques and neurofibrillary tangles, the characteristic lesions of Alzheimer's disease. These antibodies have the rare ability to cross the blood-brain barrier, allowing for non-invasive detection.
A recent study found that citizen science is a valuable source of data on species occurrence, particularly for birds in North America and Europe. However, less than 10% of this data is currently used in global biodiversity monitoring due to resource constraints and interoperability issues.
A recent study published in the journal Stem Cells found that autologous stem cell therapy after traumatic brain injury appears to reduce inflammation and preserve critical brain regions. Researchers used this approach on 25 patients, including those with severe TBI, showing promising results.
A new study co-led by TSRI scientists suggests that Ebola virus gained a genetic mutation, GP-A82V, which helps it better target human cells. This mutation emerged early in the epidemic and caused about 90% of infections during the recent outbreak.
Researchers create reconfigurable array of traps for single atoms, enabling the manipulation of up to 50 individual atoms in separate traps deterministically. The technique uses lasers as optical tweezers to pick and hold individual atoms in place, paving the way for large-scale atom arrays in quantum computing.
A new global report calls for a 5-step plan to improve hygiene practices and reduce the burden of infectious diseases in children worldwide. The report aims to halve the incidence of diarrhoea and reduce common infections such as gastroenteritis, colds, and influenza in babies and children.
Researchers used NMR spectroscopy to identify a panel of 10 urinary metabolites associated with fetal growth and increased birth weight. Changes in these metabolites could explain 12% of the variation seen in birth weight, independent of other known predictors.
A new study from Massachusetts General Hospital finds that cigarette smoking significantly reduces the lifespan of people living with HIV in the U.S., potentially even more than HIV itself. Quitting smoking can greatly increase lifespan and is never too late to quit.
A new study from Indiana University found that a low-cost workforce model can effectively reduce depression burden in primary care. The ABC Medical Home program, which utilizes trained and scalable care coordinator assistants, resulted in a 50% decrease in depression severity over six months.
Researchers found that smoking one packet of cigarettes a day accumulates an average of 150 extra mutations in every lung cell, leading to increased cancer risk. The study also identified molecular fingerprints of DNA damage in smokers' DNA, revealing the complex mechanisms behind tobacco-related cancers.
Military surgeons develop guidelines for treating devastating wounds, including massive blood transfusions and wound cleaning, to stabilize patients and prevent long-term complications. The review aims to improve trauma care in both military and civilian hospitals, reducing preventable deaths from injury.
Experts predict that soils will lose a significant amount of their carbon content, leading to increased soil erosion and flood damage. Land use changes and management practices are crucial to mitigate this trend and protect soil functions.
A new study reports that soldiers with higher blood pressure before starting prazosin treatment experience better symptom reduction. The study identifies blood pressure as a biomarker that can predict individual response to the medication, potentially leading to personalized medicine approaches for PTSD treatment.
A study identifies telltale genetic fingerprints associated with smoking tobacco, demonstrating that smoking increases cancer risk by causing somatic mutations. The research found over 20 mutational signatures linked to tobacco smoking, with some signatures elevated in cancers from smokers.
Scientists have developed multicolor electron microscopy, enabling up to three colors (green, red, yellow) to be used in an image. The new method has potential applications in biology, distinguishing cellular compartments and tracking proteins.
Scientists discovered that fluctuations in sulfur availability create atomic chains of molybdenum or tungsten in a two-dimensional alloy, controlling properties like heat transport and electronic behavior. This mechanism can be applied to a wide range of alloys in 2D crystals across the Periodic Table.
The DOE JGI has selected 37 projects for its 2017 Community Science Program, focusing on sustainable biofuels, plant microbiomes, and biogeochemistry. Researchers will utilize the DOE's sequencing capabilities to study key areas such as reference genomes for plants relevant to bioenergy production.
The US Department of Agriculture has awarded over $4.3 million to 48 veterinarians to repay their loans and provide critical services in areas lacking sufficient veterinary resources. The program aims to address shortages of food animal veterinarians, particularly in rural areas.
The 14th Report on Carcinogens adds seven new substances to the list, including five viruses that have been linked to cancer in humans. Trichloroethylene, cobalt compounds, HIV-1, HTLV-1, EBV, KSHV, and MCV are among the newly listed substances, highlighting the importance of prevention strategies to reduce the world's cancer burden.
A new procedure using a 22-gauge needle improves the diagnosis of autoimmune pancreatitis (AIP) through microscopic examination of tissue samples. Researchers successfully diagnosed AIP in 58% of patients using this method, offering a solution for distinguishing AIP from pancreatic cancer.
A team of scientists analyzed TB bacterial strains and found they can be genetically subdivided into generalists with worldwide distribution and specialists with localized ecological niches. Generalists have a slightly increased diversity of antigens, allowing them to adapt more specifically to different human populations.
The Food Hero program, launched by Oregon State University, uses a combination of clear messaging, kid-friendly recipes, and community engagement to encourage healthy eating among low-income families. The initiative has shown promising results, with over 36% of tested recipes receiving the 'kid-approved' rating.