A new program called CrispRGold helps scientists identify the most effective and specific RNA sequences for CRISPR-Cas9 system. This allows for efficient inactivation of genes in primary cells, enabling researchers to discover new genes involved in immune cell regulation.
Baylor College of Medicine has been awarded a $27.9 million grant from the National Institutes of Health to continue its knockout mouse project. The project aims to generate and phenotype lines for 1,000 new genes using Cas9/CRISPR technology.
Researchers identify Adamts1 as a key regulator of fat cell differentiation, triggered by high-fat diets and stress hormones. The hormone's production affects fat storage in different parts of the body, with implications for obesity treatment.
A single dose of dextrose gel can lower the risk of developing neonatal hypoglycaemia in newborns, according to a randomized study. The study found that babies who received one dose of 200 mg/kg dextrose had the lowest risk of hypoglycemia compared to placebo.
A new NIH-funded project aims to encourage young men at risk for HIV and other STIs to get tested using a personalized web app. The Get Connected app provides customized content based on users' risk profiles, values, and needs.
A randomized controlled trial found no significant differences between ultrasound and sham treatment for tibial fracture healing or functional recovery. The study suggests abandoning low-intensity pulsed ultrasonography (LIPUS) as an ineffective treatment option for patients with tibial fractures.
A Duke University study found that roadside garbage fires in India produce a toxic rainbow of pollutants, with concentrations 1,000 times greater than ambient air. The variability in emissions stems from the diverse trash materials and smoldering combustion, highlighting the need for improved waste management practices.
At Syowa Station, a daily mean CO2 concentration of 400.06 ppm was recorded on May 14, 2016, surpassing the previous threshold. This observation highlights the impact of human activities on the Antarctic region, contributing to global warming.
Research shows vitamin D engages with genes influencing longevity, slowing aging-related protein misfolding and increasing lifespan by 33%. The study provides a link between aging and disease, offering new insights into the potential benefits of vitamin D supplementation.
Researchers found altered brain activation patterns in pedophiles with and without a history of child sex offenses, suggesting non-offending pedophiles employ self-control mechanisms. Interventions targeting inhibitory control may help prevent child sex offenses.
Researchers at the University of Basel discovered that calcium induces the transition from acute to chronic infections in Pseudomonas aeruginosa, a life-threatening pathogen. This shift enables the bacteria to adapt and survive in the lungs, making treatment more challenging for patients with cystic fibrosis.
A new species of leggy millipede, named Illacme tobini, has been discovered in a California cave. The species boasts over 414 legs, similar to its cousin Illacme plenipes, but with unique features like poison glands and silk-secreting hairs.
A recent analysis of the ACTIVE trial results shows that abaloparatide-SC provides consistent protection against bone fractures in postmenopausal women with osteoporosis, regardless of baseline bone density or age. The therapy has been found to reduce fractures and increase bone mineral density in postmenopausal women with osteoporosis.
Research from Newcastle University found that aging brains lose their youthful folding pattern due to decreasing cortical tension. The study provides a new method for measuring brain folding and could help diagnose Alzheimer's disease.
Researchers at MDI Biological Laboratory found that early-life stress increases adult vulnerability to diseases like arthritis, asthma, cancer, diabetes, heart disease, and mental illness. Chronic exposure to cortisol in zebrafish embryos leads to abnormal immune systems and signs of chronic inflammation.
A study by University of Wisconsin-Madison researchers found that 90% of globally caught fish are from rivers with high environmental stress levels. Freshwater fish provide animal protein for 158 million people worldwide, particularly in countries like Cambodia and Bangladesh.
Researchers discovered that abscisic acid (ABA) promotes femaleness in ferns, which is linked to spore dormancy. ABA also plays a key role in regulating stomate function in flowering plants, allowing them to conserve water during drought. This study sheds light on the evolution of plant hormones and their roles in ancient species.
Researchers at NYU Tandon School of Engineering discovered zebrafish are more attracted to 3D-moving robotic models of themselves than other stimuli. The team used a controllable robotic platform to study freshwater fish behavior, exploring mechanisms behind human disorders like anxiety and schizophrenia.
Researchers reconstructed ancient atmospheric carbon dioxide record and found fluctuations projected for the 21st century. The study highlights the potential impact of losing tropical forests on climate, with potential thresholds leading to rapid and irreversible biological change.
A large international study of almost 31,500 patients showed that using older blood for transfusions does not increase the risk of death. The research, published in the New England Journal of Medicine, provides strong evidence that stored blood can be safely used to ensure a stable blood supply.
A recent study published in Journal of American Geriatrics Society found that increasing muscle strength can improve brain function in adults with Mild Cognitive Impairment. The SMART trial involved 100 community-dwelling adults who performed resistance exercise and showed significant improvements in global cognition and brain function.
The American Academy of Pediatrics recommends sharing a bedroom with parents but on separate surfaces, avoiding soft bedding and exposure to smoke, alcohol, and illicit drugs. The updated policy also emphasizes skin-to-skin care and breastfeeding for added protection against SIDS.
A Harvard Medical School study has found that mice navigate mazes by weighing all available cues before making a decision, suggesting a more complex process than previously thought. The researchers used virtual-reality maze experiments and injected mice with a virus to visualize neuronal activity in real-time.
A 21-year study found people living in remote areas were three times more likely to have a notifiable disease, with STIs six times higher. Indigenous Australians make up only 3% of the population but represent 8% of notified cases, highlighting significant under-reporting.
Researchers found that surgical reconstruction of the phrenic nerve can lead to significant improvement in breathing and an increase in regular physical activities. Eighty-nine percent of patients reported overall improvement in breathing function.
A new study found that a genetic test assessing breast cancer recurrence risk is being used to guide chemotherapy decisions in early-stage breast cancer patients. The test, which looks at 21 genes known to increase the risk of cancer recurrence, has been shown to align treatment recommendations with individual patient profiles.
A new study identifies urban expansion as the historical cause of low oxygen conditions in European lakes, with increased waste water pollution boosting biological productivity and leading to a rise in oxygen consumption.
The new evidence-based clinical guideline from the National Osteoporosis Foundation and American Society for Preventive Cardiology says that calcium with or without vitamin D intake should be considered safe for generally healthy adults. Obtaining calcium from food sources is preferred, but supplements can be used to address dietary sh...
The largest study to investigate the effects of air pollution and traffic noise found that long-term exposure is linked to a greater incidence of high blood pressure. For every 5 μg/m3 of PM2.5, the risk of hypertension increased by 22% in people living in the most polluted areas.
Researchers created an atomic-scale map of a foraminifera shell's chemistry, uncovering elevated sodium and magnesium levels in the organic layer. This discovery will improve our understanding of environmental change and climate reconstructions using ancient shells.
The International Council for Science (ICSU) and the International Social Science Council (ISSC) have voted to merge into a single organization representing social and natural sciences. The merger is expected to be completed by October 2018, with a unified global voice and institutional structure.
A University of Kent study suggests that rural areas can provide for both people and wildlife if agriculture is administered sustainably. The study recommends a policy mix combining regulatory and non-regulatory approaches, including strategic land use planning and incentives for sustainable agricultural practices.
A new study has found that features in animal teeth can detect unfavourable weather conditions, such as long dry periods or heavy rains. This method, known as reverse engineering, allows researchers to infer annual rainfall and average temperatures from fossil records, providing valuable information about past environmental conditions.
A new study led by Queen Mary University of London found a protein in pregnant women's blood could predict fetal growth and pregnancy complications. Low levels of DLK1 are associated with poor foetal growth and reduced nutrient supply to the baby.
A new human immunodeficiency has been discovered due to a faulty RASGRP1 gene, affecting T cells, B cells, and Natural Killer cells. The study identified a potential treatment using the drug lenalidomide, which reversed some effects of the mutation.
A new study from Harvard T.H. Chan School of Public Health found that elderly people displaced by disasters may experience increased symptoms of dementia. Those who lost touch with neighbors and reported depression had the highest levels of cognitive decline.
Harvard researchers develop a 3D-printed heart-on-a-chip with integrated sensors, enabling easy data collection and customization. The device mimics the structure and function of native tissue, opening new avenues for in vitro tissue engineering and drug screening research.
A simple instruction sheet significantly increases patient compliance with preoperative medication instructions, reducing errors by 40%. The intervention has been found to improve patient safety and comfort, while also limiting surgical cancellations.
The study analyzed the macrobenthic assemblages of Southern Bohai Sea over a 60-year period, revealing a shift from K strategy species to R strategy species. The succession process was influenced by environmental changes, including increased seawater salinity and temperature, and human activities such as over-fishing.
A new species of tiny, pea-sized crab has been found to parasitize a large date mussel in the Solomon Islands. The crab, named Serenotheres janus, features a unique characteristic plate on its carapace, similar to the two-faced Roman god Janus.
A microscopic sensor has been developed at TU Wien that can identify different gases simultaneously using a laser and detector in one. The sensor, made of a sophisticated layered system of materials, emits light in the infrared range and measures its strength to detect gases with unique 'fingerprints'.
Rice University scientists have discovered a new material that can store large amounts of hydrogen efficiently, making it suitable for next-generation green cars. The pillared boron nitride and graphene hybrid outperforms other materials in terms of surface area and recyclable properties.
A study at McGill University Health Centre found that women with tumors expressing the prolactin receptor had a less aggressive breast cancer and better prognosis. The research suggests screening for the prolactin receptor could indicate which patients might benefit from new treatments, potentially revolutionizing breast cancer therapies.
Researchers at Clemson University created maps showing the suitability of lands in South Carolina for generating solar energy, with a focus on five-megawatt and one-megawatt developments. The study found that about 4.2% of state land area is suitable for five-megawatt developments, enough to install 69.6 gigawatts of capacity.
Researchers argue that PISA tests only capture a snapshot of students' math skills, neglecting earlier assessments and socio-economic factors. They also suggest that better-qualified teachers can improve student performance in formal mathematics.
Scientists at Imperial College London discovered that MRSA releases decoy molecules to escape being killed by daptomycin. The decoys are made of the same type of fat as MRSA cells and allow the bacteria to evade destruction. Further experiments showed that a second antibiotic, oxacillin, can partially prevent decoy release.
A University of Washington study found that wait times for an Uber ride are shorter in lower-income neighborhoods, with average waiting times ranging from under four minutes to over 10 minutes across the city. Lower-income areas have a shorter average waiting time compared to wealthier neighborhoods.
Scientists have discovered a new target to combat severe and fatal allergic reactions by identifying a molecular motor that controls the release of inflammatory factors. Researchers found that depleting this motor reduces mast cell granule transport and release, potentially leading to new treatment options for anaphylaxis.
A new study has found measurable brain changes in children after a single season of playing youth football, even without a concussion diagnosis. The research team analyzed head impact data and multimodal neuroimaging to determine the risk-weighted cumulative exposure associated with a single season of play.
A new mathematical model describes the relationship between belief systems and interpersonal influence, revealing an underlying cognitive consistency that links multiple beliefs. The model has the potential to study overlooked complex issues by analyzing the structure of logic constraints.
Researchers reconstructed the genomes of over 2,500 microbes from sediment and groundwater samples, revealing an incredible 80% of known bacterial phyla. The discovery sheds new insights into the importance of subsurface microbes in carbon, nitrogen, and sulfur cycles.
Researchers discover a cellular mechanism by which brain deactivates and then gradually reactivates neurons in the temporal association cortex. This discovery challenges the idea that all neurons are present and fully active from birth.
For the first time, fetal medicine experts have performed prenatal heart surgery to remove a life-threatening tumor, called intrapericardial teratoma. The patient is now a healthy preschooler after undergoing the operation at 24 weeks of gestation.
Researchers at NICT have developed a flexible optical design method for superconducting nanowire single-photon detectors, enabling high detection efficiency over a precise spectral range while rejecting other wavelengths. This technique has potential applications in quantum cryptography, fluorescence spectroscopy, and remote sensing.
Researchers identified genetic changes in DUX4 and ERG transcription factors that underpin a subtype of acute lymphoblastic leukemia (B-ALL) in children. The study found a unique mechanism involving the interplay between these two transcription factors, leading to deregulated expression of ERG and development of leukemia.
A new cancer treatment combines four therapies to activate both branches of the immune system, leading to complete disappearance of large tumors in mice. The approach allows the immune system to remember the target and destroy new cancer cells that appear after treatment.
A new study finds that bird-like dinosaurs were social animals, living and dying together in groups. The discovery of a rare bonebed in Mongolia highlights the increasing trend of gregariousness in dinosaurs and emphasizes the need to protect against fossil poaching.
Researchers at MIT used cellphone data and crowd-sourced images to identify visual features that contribute to perceptions of safety in urban environments. The study found that buildings with street-facing windows, green spaces, and well-maintained areas increase people's sense of safety, while poorly maintained areas decrease it.
Younger pregnant women are at increased risk of stroke compared to their nonpregnant counterparts, with the youngest group seeing more than doubling of stroke risk. The study found that PAS accounted for 15% of strokes in younger women, and death was lower among those with PAS.
Researchers propose using insect repellents along with insecticides to drive mosquito evolution that yields greater aversion to repellents, potentially slowing malaria development. This strategy could extend the lifetime of current insecticides and reduce resistance by favoring repelled mosquitoes over those developing resistance.