A study by Ludwig Cancer Research identified a metabolic vulnerability in glioblastoma cells that can be exploited for therapy. GBM cells are extremely dependent on imported cholesterol and shutting down their import controls leads to dramatic cancer cell death and tumor shrinkage.
A Johns Hopkins pilot program proves safe and effective in reducing sedation and boosting early mobility for children in intensive care units. The PICU Up! Early Rehabilitation and Progressive Mobility Program includes activities such as sitting, standing, and walking, resulting in increased rates of physical therapy consultations and ...
The NIH has expanded its Precision Medicine Initiative Cohort Program to California, partnering with eight regional medical centers. The program aims to engage one million or more US participants in a longitudinal research effort to improve disease prevention and treatment based on individual differences.
A new study reveals that household wastewater can release disease-causing pathogens into the air during irrigation, contaminating crops. On moderately windy days, up to 89% of these pathogens were released within half an hour of soil irrigation.
Researchers create a closed-loop system to test their proposed method, which is a better fit for how humans actually behave compared to traditional models. The new model uses fractional order calculus to describe human operator behavior, providing a unified and formalized description.
Researchers found that CTA tests led to higher adoption of preventive measures and healthier lifestyle practices compared to exercise electrocardiography and stress tests. After 60 days, more people who underwent CTA tests started taking aspirin, statins, and beta-blockers, and eating healthier, with lower rates of obesity.
A study published in the Journal of Clinical Nursing found that alcohol-related injuries occurred predominantly at home, accounting for 36.1% of cases. Men were more likely to be seen at emergency departments for at-home injuries compared to females.
Researchers at Binghamton University found that a genetic polymorphism in the CD40 gene modifies the severity of Duchenne muscular dystrophy, pointing to potential therapeutic approaches. The study suggests that drugs targeting CD40 may improve patient symptoms.
Planting angle, cordon height, and bud selection significantly impact canopy establishment in UFO trees. Effective practices can increase grower success and reduce crop load potential, optimizing labor efficiency and uniformity.
A new study by psychologist Tomas Jungert found that warm student-teacher relationships are linked to intrinsic motivation, which drives students to defend victims of bullying. In contrast, conflicted teacher-student relationships are associated with extrinsic motivation, leading students to remain bystanders or side with bullies.
A global study suggests that tracking migrating birds' routes could provide early warning of potential bird flu outbreaks. Researchers found that long-distance flights of infected birds from Asia to Europe and North America via their breeding grounds in the Arctic are a key factor in spreading deadly strains of avian flu.
Researchers at UBC's Okanagan campus have identified three types of sulphur oxidizing bacteria and two types of iron-oxidizing microbes that contribute to acid-rock drainage. The study aims to develop a new method of managing mining waste by returning it to its natural state without ponds or caps.
Scientists investigate how water flows near superhydrophobic surfaces, finding that liquids can exhibit unusual properties like hydrodynamic slip. The research uses an atomic-force microscope to measure the slip length and develop new theories for these systems.
Nearly one in three Myanmar citizens have hypertension, while half have high cholesterol. Experts warn that poor lifestyle choices are contributing to a surge in heart disease.
The MINOS and Daya Bay experiments have published a paper that sheds new light on sterile neutrinos. The joint analysis excludes most possible sterile neutrino oscillation scenarios that could explain the LSND result, significantly shrinking the hiding space for a light sterile neutrino.
Scientists have discovered an enzyme called ALKBH1 that can remove molecular modifications from transfer RNA (tRNA), causing a measurable effect on protein translation in the cell. This finding sheds new light on how cells control gene expression and suggests that tRNA influences cellular processes beyond protein translation.
A team of 90 institutions from 44 countries found that forests with many tree species are more productive than those with few, providing an estimated USD$166-490 billion in annual economic benefits. This discovery highlights the need for a re-assessment of biodiversity values and conservation priorities.
Beardedness is associated with increased attractiveness in women when evaluating long-term relationships due to its signal of formidability and potential benefits. Stubble appears most appealing for short-term connections, while full beards are preferred for long-term partnerships.
Researchers analyzed 300 published works on silver nanoparticles and wastewater treatment, finding no adverse effects at current concentrations. The team suggests that moderate or high concentrations could pose a problem in decades to come.
Researchers found that flowering ornamentals can provide critical biological services such as pollination and biological controls. The study identified 74 commercially available annual and perennial plant species that attracted a diverse population of pollinators and beneficial insects, including hoverflies, skippers, and native bees.
Researchers will explore materials based on Gallium, Lanthanum and Sulphur (GLS) for IR applications, offering a safer alternative to arsenic-based glasses with improved performance.
The universal two-child policy is predicted to have a relatively small effect on population growth, with a peak of 1.45 billion by 2029. However, it may lead to changes in retirement age and pension systems to address shrinking workforce and population ageing.
Researchers developed an MRI-based method to track the state and progression of genetically mutated brain cancer using a new biomarker 2HG. This non-invasive method provides a diagnosis when neurological risk from surgery is too high, and allows for rapid assessment of treatment response.
Researchers at Nagoya University have identified a novel potential target of the type 2 diabetes drug metformin: the ion exchanger protein NHX-5. In nematode worms and fruit flies, metformin targets NHX-5 to disrupt autophagy and related subcellular processes.
Tropical Depression 24W formed on Oct 12 and moved west toward the Philippines on Oct 13, with NASA's Aqua satellite revealing cold cloud tops indicating potential for heavy rainfall. The depression is forecast to strengthen into a typhoon and make landfall in eastern Luzon late on Oct 15 or early on Oct 16
Researchers at Women & Infants Hospital have received NIH grants to evaluate treatment strategies for perinatal brain injury. The studies aim to prevent or decrease brain damage in infants at risk for cerebral palsy and other developmental disabilities.
Researchers analyzed viral samples and wild bird migration patterns to understand the spread of H5N8 avian influenza. The study found two main migration routes for the virus, suggesting direct or indirect contact with infected birds as likely transmission methods.
Researchers will study cellular and molecular mechanisms of lung regeneration, targeting AT2 cells with gene editing techniques to correct disease-causing mutations and promote repair.
Scientists have discovered silicate glass spherules at the Paleocene-Eocene boundary that suggest a comet impact occurred during this time period. The results provide direct evidence for an extraterrestrial impact on Earth, which may have contributed to the observed global warming event.
Two researchers will receive funding to explore the use of smartphone-connected technology and wearables to predict radiation toxicity in lung cancer patients. A randomized trial will investigate whether a simple walking program can reduce treatment interruptions and improve outcomes among cancer patients undergoing concurrent chemothe...
Researchers have developed a flexible, disposable sensor for monitoring proteins in the blood released from damaged heart muscle cells after a heart attack. The sensor uses nanostructures to detect low concentrations of troponins with high accuracy, enabling quick diagnosis and treatment at home.
Researchers found that the cutting of tau by caspase-2 may play a critical role in the disordered brain circuit function of tauopathies. Blocking caspase-2 activity restored some learning and memory deficits in animal models, suggesting reversible cognitive loss.
Researchers found that positive attitudes towards marriage dampen risky behaviors among lighter-skinned African Americans and Asians, but have little effect on darker-skinned individuals. The study suggests that promoting healthy attitudes toward romantic relationships could encourage better decision-making and behaviors.
Researchers found that the moon's uppermost surface materials are completely turned over in approximately 80,000 years, much faster than previously estimated. This discovery has significant implications for future human exploration and development of the Moon.
A UT Dallas study found that construction firms in the Gulf region operate with limited safety regulations or enforcement, leading to a high risk of accidents among migrant workers. The study identified inadequate training, language barriers, and a lack of effective communication as key causes of these accidents.
Quiescent human cells exhibit an inflammatory profile similar to acute infections when energetically stressed, suggesting a pro-survival strategy may not be well-suited for long-term chronic stresses. This could impair genome repair and increase cancer risk.
Changes in protein modifications generate biological diversity needed for evolution, allowing species to adapt to environments. Most phosphorylation sites arose relatively recently in evolution, contributing significantly to evolutionary diversity and highlighting potential avenues for therapeutic research.
The University of Arizona's INSITE Center helps Fortaleza city planners use big data to understand bus delays and overcrowding. The team developed an online dashboard with real-time data on bus movements, passenger numbers, and weather conditions to inform decision-making.
A new study found that spraying barley crops with an RNA molecule inhibits fungus growth, while the plant's vascular system transports it to distant infection sites. The researchers also identified a key protein involved in the process.
Researchers at the University of Pennsylvania have identified a new mechanism by which RNA molecules are degraded in plants, occurring co-translationally with translation. This process is linked to gene regulation and may play a role in stress response.
Hurricane Nicole is a Category 3 hurricane with maximum sustained winds near 125 mph, expected to bring significant effects to the region. The storm is predicted to pass near Bermuda today, posing a threat to the island's residents and infrastructure.
Researchers from University of Wisconsin-Madison have revealed a fabrication process for revolutionary transparent sensors, which can be used for brain imaging, electrophysiology, fluorescent microscopy, optical coherence tomography, and optogenetics. The technology has the potential to expand its applications into areas such as stroke...
Interdisciplinary research highlights changing scientific landscape, where large data sets and computational methods encourage an iterative approach. The authors note that despite new technology, the reinvigorated approaches are rooted in centuries-old debates over iterative and hypothesis-driven science.
A study presented at the Argentine Congress of Cardiology found that smoking rates increased from 42% to 69% in heart attack patients between 2011 and 2015, coinciding with a 100% increase in cigarette affordability. Despite improved treatment for heart attacks, mortality rates remained unchanged.
A recent study found that an invasive tropical legume tree, Leucaena leucocephala, alters soil nitrogen dynamics in Guam ecosystems, reducing soil nitrogen levels. The research also revealed changes in microbiological processes that control soil chemistry transformations.
Florida State University geology researcher Mainak Mookherjee explores feldspar elasticity to explain seismic discontinuity. At extreme pressures, feldspar decomposes into denser mineral phases, which could partially explain this phenomenon.
A genomic study by University of Nevada, Reno researchers identifies a newly discovered bird species evolving with its food source in southern Idaho. The South Hills crossbill has evolved unique dependencies on the Rocky Mountain lodgepole pine tree over 6,000 years.
Researchers found that depriving brain tumor cells of cholesterol specifically kills them and causes tumor regression. This alternative method targets glioblastomas, the most aggressive form of brain cancer, which are difficult to treat due to their biochemical composition and blood-brain barrier.
Hurricane Matthew's heavy rainfall caused widespread flooding and deaths in North Carolina, with rivers still rising on Oct. 12. The NASA rainfall analysis used IMERG data to estimate the storm's total rainfall, which was over 20 inches in some areas.
Researchers have created mid-air displays of 'floating pixels' using soundwaves and force fields, opening up new possibilities for computer and mobile displays in the 3D space above the screen. The technology, called JOLED, can be used to create interactive displays and bring digital information to life as physical objects.
A new study revises the understanding of childhood diarrhea's causes, finding nearly 90% of cases are linked to pathogens. The research provides a roadmap for developing vaccines and treatments for six top causes, aiming to reduce deaths by 70 percent annually.
Research on grafting tomatoes in high tunnels found that grafted plants yielded significantly more than nongrafted controls, with yield increases ranging from 18% to 126%. The effect of scion shoot removal was not as consistent, but some trends suggest that rootstock vigor plays a role.
A 7-state research consortium led by Henry Ford Health System has been awarded funding to expand the NIH's Precision Medicine Initiative Cohort Program. The program aims to enroll 1 million participants and collect data on lifestyle, environment, and genetics influencing health and disease risk.
A new study by UMass Amherst researcher Bernhard Leidner investigates the consequences of national trauma for both victims and perpetrators. The research aims to explore how different perceptions of intergroup violence and trauma can escalate or de-escalate conflict.
Researchers will investigate the use and effectiveness of alternative methods of electronically sharing health information in primary care settings. The study aims to determine which approach, 'push' or 'pull', is more effective for providers and quantify its impact on potentially avoidable healthcare utilization.
Research by University of Toronto scientists found that adult ruby-throated hummingbirds choose to balloon up in weight before flying south for the winter. They discovered that individual hummingbirds make decisions based on experience, with some fatten up to gain an advantage over rivals and establish territories quickly.
A new imaging method has captured the daily disposal and regeneration of photoreceptor cells in a living human eye, revealing crucial insights into blinding diseases such as age-related macular degeneration and retinitis pigmentosa. The study's findings have the potential to improve our understanding of vision and eye health.
Dense molecular gas disks are supplying gas directly to supermassive black holes at galaxy centers. The growth of supermassive black holes is enhanced by strong turbulence generated by supernova explosions in these disks.
A recent study published in BMC Public Health found that people with higher levels of social connection have better health literacy. Researchers also discovered that volunteering and civic engagement are linked to improved health literacy. The study analyzed data from the National Assessment of Adult Literacy, highlighting the importan...
Researchers found that exercise and methamphetamine can re-establish circadian rhythmicity in animals, suggesting a potential new way to treat addiction. This approach associates drug usage with a non-harmful stimulus, leveraging brain plasticity to rewiring the brain's circuitry.