A recent study has discovered a strong link between genetic mutations and sensitivity to specific drugs in patient-derived cancer cell lines. The researchers found that these cell lines harbor most of the same genetic changes found in patients' tumors, making them useful models for identifying effective treatments.
Professor Falk's interdisciplinary research has led to breakthroughs in assistive technology and disease diagnosis. He will receive the award at Sigma Xi's annual meeting, discussing challenges posed by his work.
Researchers created super-sniffer mice using transgenic technology to study human odor receptors, which could lead to land mine detection and novel disease sensors. The mice were able to detect a specific odor two orders of magnitude lower than non-super sniffer mice.
A Michigan State University researcher is helping a farmers market and local food sources go mobile in Flint, providing healthier options to those most in need. The mobile market will offer fruits, veggies, meat, cheese, dairy, grains, and other foods, with community buy-in essential for its success.
The University of Illinois at Chicago is part of a national initiative to enroll 150,000 participants in the Precision Medicine Initiative Cohort Program. Participants will share health and lifestyle data to develop personalized prevention strategies and treatments.
A study found that a twice daily program of assisted range-of-motion exercises significantly improves bone strength in very low birth weight pre-term infants. This could lead to a reduced risk of osteopenia and future fractures.
A recent study by Avni Shah at the University of Toronto found that paying with cash increases feelings of connection and attachment to purchases, while credit cards may lead to a decrease in emotional attachment. This phenomenon is attributed to the 'pain of payment', which varies depending on the type of payment method used.
Research suggests that the location of ulnar collateral ligament (UCL) tears in MLB pitchers can predict non-operative treatment failures and guide surgical recommendations. Distal UCL tears are more likely to require surgery than proximal tears.
A study found that severe non-proliferative and proliferative diabetic retinopathy stages are associated with increased depressive symptoms in people with diabetes. Moderate or severe vision impairment, but not diabetic macular edema, contributed to the risk of depression.
Scientists at Vanderbilt University have developed monoclonal antibodies that effectively neutralize the H3N2 variant virus (H3N2v) in human subjects who received an experimental vaccine. These antibodies were able to neutralize H3N2 strains circulating between 1995 and 2005, but not currently circulating human H3N2 strains.
Research suggests that extra-coding RNAs play a critical role in regulating DNA methylation patterns in the adult brain, particularly in memory formation. By interacting with DNA methyltransferase enzymes, ecRNAs control the addition or removal of methyl groups at precise spots on chromosomal DNA.
The BMC Vital Village Network has received a $500,000 strategic planning grant to develop infrastructure supporting children entering kindergarten at a healthy weight. The project aims to promote healthy growth and development through a two-generation approach, involving community settings from preconception to age 5.
A new platform harnesses DNA as the engine of a microscopic nanomachine, detecting trace amounts of substances such as viruses, bacteria, and metals. The technology uses selectively triggered DNA molecules to create a signal, enabling ultra-sensitive detection and potential clinical testing.
Researchers at NYU Tandon School of Engineering have developed a technique called LAVA, which intentionally adds vulnerabilities to source code to test bug-finding tools. The results show that many popular bug finders detect only 2 percent of vulnerabilities, highlighting the need for improvement.
Scientists track brain-cell activity in mice to gain insight into how the brain creates a map to a destination. The study found that two sublayers of cells in the hippocampus process different types of learning, with one layer creating a stable internal map and the other layer updating it during navigation.
A study published by the University of Oxford found that man-made climate change was responsible for hundreds of deaths in two European cities during a 2003 heatwave. The research used computer simulations and health impact assessments to estimate the number of premature deaths attributed to climate change.
The Atmospheric Tomography (ATom) mission surveys the atmosphere over oceans for the first time, measuring pollutants and climate gases. The DC-8 aircraft will document interactions between air masses, understanding where pollutants originate and how quickly they react chemically.
A new study by Iowa State University researchers suggests that prolonged periods of food insecurity coupled with harsh parenting practices can lead to obesity in early adulthood among female adolescents. The study's findings indicate that females who experience food insecurity are more likely to be overweight or obese by age 23.
Astronomers have discovered a planet in a unique position between three stars, experiencing constant daylight or triple sunrises and sunsets. The planet, HD 131399Ab, is one of the youngest exoplanets discovered to date and has a wide orbit within a multi-star system.
A study reveals that rapid TB tests in West Africa have low accuracy due to the presence of other mycobacterial species like Mycobacterium africanum. The tests miss a substantial fraction of cases, leading to dire consequences for patients and TB control efforts.
A team of researchers used a custom-built robot, mathematical models, and studies of amphibious fish to explore the critical evolutionary leap from water to land. They found that stabilizing the body with a tail provided substantial benefits for early terrestrial vertebrates.
Researchers found that immune checkpoint blockade improved survival and promoted immune cell infiltration into tumors when combined with an antitumor vaccine. The study suggests PD-1 and PD-L1 may help tumors evade vaccines, supporting testing of therapeutic combinations in clinical trials.
Researchers found that sub-sensory vibratory noise delivered to the foot sole of older adults significantly augmented postural control complexity, leading to improved mobility and reduced TUG times. This study highlights the potential benefits of vibratory stimulation for enhancing physical function in older adults.
Researchers have discovered a new ferromagnetic superconductor, CsEuFe4As4, where both bulk superconductivity and full ferromagnetism are realized simultaneously. The material exhibits robust SC and FM, with the ferromagnetic ordering demonstrated by field-dependent magnetization.
Scientists have developed a new method that can accurately identify brain regions triggering seizures in people with epilepsy. The technique, using advanced mathematical modeling procedures, has shown promising results in predicting successful surgery outcomes.
A team of researchers from the Instituto de Astrofísica de Canarias has discovered a new gaseous component in a planetary nebula, which is helping to understand the chemical evolution of our Galaxy. The component, rich in heavy elements such as oxygen and carbon, was detected using the OSIRIS instrument on the Gran Telescopio CANARIAS.
Visits to emergency departments for hypertension increased by 64% between 2002 and 2012, despite a decline in hospitalizations. Aggressive home monitoring may be driving patients to ERs without other emergency conditions. Mortality rates were low, with less than 1% of patients dying within 90 days.
Researchers developed a system to predict storm damage by waves in the North Sea, focusing on densely populated areas. The model simulates waves and tidal currents, indicating interactions between waves from different directions play a fundamental role in wave climate.
Research finds The Blob had a stronger negative impact on marine productivity than El Niño off the West Coast, with ocean warming slowing nutrient flow and reducing ecosystem productivity. The study uses real-time data from autonomous gliders to assess the effects of major climate disruptions.
A large multicentre study found that freeze-all embryo protocols are associated with significantly improved IVF outcomes, particularly in women over 35. The study showed a 13% increase in ongoing pregnancy rates for these patients compared to traditional fresh embryo transfer methods.
Researchers have found evidence of water clouds in WISE 0855, a nearby brown dwarf that is the coldest known object outside of our solar system. The team used spectroscopic observations to study its composition and chemistry, revealing a spectrum dominated by water vapor and clouds.
A team of researchers at Nagoya Institute of Technology has developed a method to synthesize complex, versatile materials from starting materials with low reactivity. The synthesis uses the catalytic Mannich reaction to produce chiral imidazolines with high yield and stereoselectivity.
The Rhode Island Center for Clinical Translational Science will create an educational and technical infrastructure to spur medical studies, expand access to population health data, and support clinical research. This $19.5 million grant aims to bring discoveries from the lab to the clinic and improve patient care.
Scientists have pinpointed D2 neurons as key players in regulating drinking behavior, discovering they discourage action and inhibit excessive consumption. Activating these 'no-go' neurons could help prevent problem drinking behavior, paving the way for new treatments.
Researchers found that blue tit males feed their partners more frequently when they are younger and less experienced, but less often when temperatures rise. This helps the females forage for food without interrupting incubation.
Researchers discover that high densities of nests on Raine Island limit hatching rates due to oxygen depletion and bacterial buildup. Pumping air into the nests may boost hatching rate, explaining similar phenomena in other turtle species.
Researchers at UCL have created a new approach to simulate virtual universes, allowing for accelerated research into the effects of dark energy and dark matter. By comparing results from large studies to computational models, scientists can gain more accurate predictions and explore alternative versions of these mysterious substances.
Whole-genome gene expression and methylation data offer more predictive power than commonly-used clinical information in breast cancer survival predictions. Combining these data with clinical information improves predictions, suggesting a promising genomic approach for future clinic applications.
Researchers found that mitochondrial stress triggers metabolic shifts through the p53 protein in cancer cells, leading to increased glycolysis and possible new targets for therapy. The study suggests that markers of metabolic stress could serve as a biomarker for cancer aggressiveness.
A genetic test detecting tumor DNA in blood accurately predicts colon cancer recurrence in some patients. The test could help clinicians decide which patients need additional treatment after surgery, improving diagnostic approaches and potentially increasing survival rates.
A new microfluidic device has been developed to study the effects of electric fields on cancer cells, effectively stopping their growth and spread. The device uses low-intensity, middle-frequency electric fields to preserve healthy cells.
Researchers at Case Western Reserve University have discovered that analyzing image features from adjacent benign tissues to tumor areas can provide an early warning for patients at higher risk of biochemical recurrence. This study may lead to doctors making decisions sooner about follow-up therapies or more regular monitoring.
A recent European Commission-funded study examines how children in European countries are influenced by online marketing, revealing significant impacts on purchasing behavior. The study found that all popular online games and half of mobile apps contain embedded advertisements, often not understood by child consumers.
Researchers found that the Atchafalaya Basin, with restored access to riverine sediment, is more stable than surrounding areas like Terrebonne Basin. The basin has emerged above mean sea level and maintained its shoreline despite rising waters and sediment loss.
A systematic review found that the IMCI strategy may lead to slightly fewer deaths among children under five years old. However, its effect on other issues such as illness and quality of care was mixed. The review's findings suggest that while IMCI may be beneficial in certain settings, its cost-effectiveness is uncertain.
Scientists have uncovered how the combination of nuclear and mitochondrial genomes triggers a cellular adaptation that determines aging. The study provides valuable information on using mitochondrial donation technology to prevent disease-causing mutations.
Experimentalists discovered calcium-52 had a large charge radius, challenging its status as a magic nucleus. Theoretical research using Titan supercomputer confirmed the trend without kink in charge radius graph, but even advanced models couldn't perfectly match experimental data.
Researchers found that viral hepatitis is now a leading cause of death and disability globally, killing at least 1.45 million people annually, surpassing TB, malaria, and HIV/AIDS. The disease burden is more evenly divided between high- and low-income countries.
A study by researchers at the University of Michigan found that long-term marijuana users show a decreased response in their brain's reward system, making them more susceptible to addiction. This decrease can lead to a blunted emotional response, also known as anhedonia.
Satellites captured a developing eye in Hurricane Blas, showing a cloud-filled and wide storm system. The hurricane is moving west-northwest at 12 mph and has maximum sustained winds of near 125 mph.
A new study reveals prehistoric sea worm Oesia built tube-like dwellings on the sea floor, inhabited by a filter feeder with gills. The findings confirm Oesia as a primitive hemichordate and provide evidence of a distant common ancestor shared with vertebrates.
The ESMO consensus guidelines reflect a personalized treatment approach to managing metastatic colorectal cancer, incorporating molecular markers and patient selection. The guidelines aim to improve outcomes by providing evidence-based recommendations for treatment options.
Research suggests that cigarette butts can leach metal contaminants into the marine environment and potentially harm local species. The study found varying levels of metals in cigarette butts at nine locations along the Persian Gulf, with significant changes not detected between assessments.
Researchers have identified the key cellular mechanism behind antipsychotic-induced parkinsonism, which includes involuntary movements and tremors. By targeting dopamine D2 receptor blockade in specialized neurons, a new approach to designing novel antipsychotics without side effects may be possible.
Researchers found that pre-assessment of moral free riders can stabilize costly moral systems and promote cooperation. This approach considers a pool account where individuals can contribute in advance, allowing for more efficient detection of those unwilling to pay for justice.
A research group has made progress in obtaining bio-oils and raw materials from biomass using its patented reactor. Artificial neural networks are being used to calculate the gross calorific value of biomass, which is essential for designing and improving biomass pyrolysis, gasification, and combustion systems.
Data from Japan's Hitomi X-ray satellite shows that supermassive black holes play a crucial role in the evolution of galaxies, regulating their growth by releasing energy that keeps plasma hot. This heat prevents galaxies from forming new stars and becoming even larger.
Research shows that pelleting and extrusion increase digestible and metabolizable energy in diets for pigs, regardless of fiber content. Pelleting alone or combining with extrusion provides greater increases in amino acid digestibility, improving energy utilization.
As air pollution increases, hydrocarbon molecules break down, confusing bees and increasing foraging time. This affects not only generalist but also specialist bees, impacting pollination and ecosystem balance.
Researchers at Massachusetts General Hospital found a link between obesity and decreased response to chemotherapy in pancreatic cancer patients. Inhibiting the AT1 signaling pathway may be an effective strategy to overcome this obstacle.