A new study published in CMAJ found that people living in regions with better access to preventive healthcare had lower rates of cardiac events. Regions with high cardiovascular event rates were associated with lower dietary intake and higher obesity rates.
A team of researchers at the University of Iowa documented how melanoma cells form tumors in a 3D model, finding similarities with breast tissue cancer cells. They identified two drugs, anti-beta 1 integrin/(CD29) and anti-CD44, that block tumor creation in both types of cancer.
Researchers at DGIST have identified a mechanism to reverse cellular aging and promote recovery through the inhibition of ATM protein. By activating lysosomal functions, they were able to restore cell division capacity and induce wound healing in aging animal models.
A new study found that brain signals associated with fullness are dulled in obese children, leading them to overeat and gain weight. Obese children's brains responded more strongly to high-calorie foods after eating, suggesting a blunted satiety response.
A phase 3 trial found that a natural combined estradiol-progesterone capsule significantly decreased moderate to severe hot flashes in postmenopausal women. The treatment was well-tolerated with minimal side effects, presenting an alternative to unregulated hormone therapies.
Researchers developed an experimental treatment that tames the immune system in rodents, restoring movement to paralyzed mice. The approach may combat autoimmune diseases in humans, as demonstrated in mouse models of multiple sclerosis and type 1 diabetes.
Researchers found that timing strawberry blooms directly after neighboring apple blossoms results in higher yields due to increased pollinator activity. This strategy allows growers to capitalize on the services of pollinators without relying on external inputs like fertilizers and pesticides.
Scientists uncover a potent genetic element in microorganisms that enable them to self-mutate, expanding the diversity of the tree of life. The discovery reveals how rapid evolution happens in some of Earth's smallest and most common microbes.
Researchers found that schools with high levels of social capital outperformed those with low levels in state-mandated math and reading tests. Social capital is a network of relationships between school officials, teachers, parents, and the community.
Virginia Tech researchers discovered that Android apps collude to mine user information, compromising security. The study found thousands of pairs of apps that could leak sensitive data, with the biggest risks coming from seemingly innocuous apps like ringtones and widgets.
Dr. French is recognized for his groundbreaking research and extensive writing about alcoholic liver disease, totaling over 450 peer-reviewed papers and 19,470 citations.
A new study measures potentially damaging free radicals in cigarette smoke for the first time, finding variations in their levels across different cigarettes. The researchers' standardized protocol could help assess people's exposure to free radicals and inform potential health risks.
Researchers used gold spring-shaped coils to enhance interactions between light and chiral molecules, enabling detection of minute amounts. The study's findings have potential applications in pharmaceutical design, telecommunications, and nanorobotics.
Researchers developed the Behavior Pain Assessment Tool (BPAT) to evaluate pain in critically ill patients unable to communicate verbally. The tool, based on eight observable behaviors, was validated in 28 countries and found to be reliable and valid for use in clinical practice.
Researchers at Fred Hutchinson Cancer Center are developing T-cell therapies for a type of acute myeloid leukemia. They aim to create targeted immunotherapy that recognizes and kills cancer-specific proteins within the cell.
Cornell University scientists discovered a high-definition system allowing electrons to travel through soil more efficiently than previously thought. Biochar amendments facilitate this process, promoting conductive networks and growth.
A review of studies suggests substituting nurse practitioners, physician assistants, and nurses for physicians can achieve comparable patient outcomes in terms of morbidity, mortality, satisfaction, and quality of life. However, more research is needed to confirm the cost-effectiveness and quality of healthcare.
Researchers discovered that motivation shifts from promotion to prevention as people make progress toward their goals. This shift can be leveraged to improve goal-attainment by focusing on avoidance strategies rather than positive aspects.
A clinical trial of nivolumab found that 16% of patients with advanced nonsmall cell lung cancer survived at least five years, significantly higher than the standard 1-4% survival rate. Researchers hope to identify specific genetic markers linked to long-term response.
A new simple tool can help identify individuals with a higher risk of developing prediabetes. The tool is based on the time it takes to reach a maximal sugar level during an oral glucose tolerance test, indicating poorer pancreatic function and increased risk for diabetes.
A team of researchers has discovered a unique assemblage of prehistoric artefacts, including disc-shaped beads and pendant objects, dated to between 30,000 to 22,000 years ago. The findings challenge the theory that Pleistocene human culture declined in sophistication as Homo sapiens ventured beyond India into Southeast Asia.
Researchers from UConn Health have developed a way to regenerate rotator cuff tendons after they're torn, creating stronger repairs. The nano-textured fabric seeded with stem cells helps the tendons attach better to the bone and heal more evenly.
Scientists have identified a biomarker, SMARCE1, that distinguishes poorly invasive tumors from those likely to spread and metastasize in early-stage breast cancer. This discovery enables doctors to tailor therapies designed to match the behavior of each patient's cancer, improving treatment outcomes.
Research teams identified two cyclic peptides that can shut down an enzyme long thought to be undruggable for fighting disease-causing parasites and bacteria. The finding could lead to the development of new antimicrobial drugs.
The Ecological Society of America recognizes six graduate students for their policy work, providing them with training and opportunities to meet policymakers. The students will learn about the legislative process and federal science funding, aiming to bridge the gap between science and policy.
In this study, researchers created physically embodied robots to examine the interaction between genetic and epigenetic factors in robot evolution. The results show that robot populations with an epigenetic factor evolved differently than those without, highlighting the importance of including epigenetic factors in robot evolution.
Researchers have developed a new humanized mouse model of colorectal cancer, allowing them to test immunotherapies and potential combination treatments. The model has shown promise in preclinical studies, including the successful activation of the immune system against cancer cells.
Researchers at Imperial College London found that malaria parasites change the properties of red blood cells to facilitate entry, making them more susceptible to infection. This discovery suggests that naturally flexible cells may be easier for parasites to invade, prompting further investigation into host-directed therapies.
Researchers found that adding a soft foam layer to shoulder pads reduces the severity of shoulder-to-head impacts, resulting in a 25% decrease in linear acceleration and 12% reduction in rotational velocity. This innovation has potential to prevent brain injuries in ice hockey.
A combination of two drugs targeting molecular pathways controlled by the RAS gene has shown promise in treating RAS-driven lung, ovarian, and thyroid cancers. Patients with heavily treated cancers have experienced long-term clinical benefit from the treatment, including one patient on treatment for over two years.
A new triple inhaler has shown a 20% reduction in chronic obstructive pulmonary disease (COPD) flare-ups in a year-long trial involving 2,691 patients. The study found that the inhaler improved lung function and reduced symptoms, with potential benefits for early diagnosis and targeted treatment.
Researchers at NTT Corporation have combined a sub-wavelength nanowire with a photonic crystal platform to demonstrate two key firsts: Continuous-wave lasing oscillation by sub-wavelength nanowire, as well as high-speed signal modulation by a nanowire laser. This breakthrough overcomes material incompatibility issues and enables the de...
A study found that real-world massage therapy produced clinically meaningful improvements in low back pain for primary care patients, with significant effects seen in adults from baby-boom and older generations. However, the benefits were not retained over time for obese patients, while those taking opioids showed less improvement.
A study of over 3,000 childhood cancer survivors found that 12% carry germline mutations associated with increased cancer risk. Genetic screening is recommended for these patients to prevent future cancers and design personalized therapeutic approaches.
Patients with good provider communication are more likely to use prescribed cholesterol-lowering statin drugs, take aspirin, and comply with treatment plans. They also experience better health outcomes and lower healthcare expenditures compared to those with poor communication.
Researchers used chemical maps to visualize original paint layers under overpainted surface of Ghent Altarpiece. The technique revealed the overall good condition of the original scenes, supporting the decision to remove all overpaints.
A study by researchers at the University of Chicago and Yale/Cornell universities found that liberal and conservative readers have distinct preferences for scientific subjects and books, with liberals preferring basic sciences and conservatives favoring applied disciplines.
The study found that E4 lowered testosterone levels in healthy male volunteers, with decreasing total and free testosterone, FSH, and estradiol levels. The hormone was well-tolerated, with only libido decrease and nipple tenderness reported.
The creation of a Bose-Einstein condensate in nickel chloride enables the calculation of macroscopic properties, such as magnetic moments, by treating atoms as waves. This breakthrough uses a single wave function to describe the behavior of a large group of atoms.
A new study conducted in rats found that mothers' alcohol use before conception can harm their offspring's glucose function, increasing the risk of developing diabetes. The research suggests that pre-pregnancy alcohol exposure may be passed on to the child, leading to lifelong effects on glucose homeostasis.
A new system has been developed to sample, measure, categorize and control nuisance odors from sewage and wastewater treatment facilities. The technology uses a range of methods, including plastic bags, metal containers and electronic noses, to identify the sources of the smells and develop strategies for elimination.
Scientists have made a breakthrough in developing longer-lasting sunscreens by studying the behavior of molecular ingredients. By using lasers to simulate sunlight, researchers found that up to 10% of sunscreen molecules can become stuck in an excited state, leading to degradation and reduced protection.
Researchers from Durham University found that only a quarter of the UK's largest shale gas reserve might be recoverable due to limited space for well development. To minimize land disruption and environmental impact, they recommend locating wells as far apart as possible and operating on a multi-well basis.
A crucial protein called Polydom is essential for developing a functioning lymphatic system. The protein promotes signaling by the Angiopoietin-2-Tie1/Tie2 pathway, which is vital for lymphatic vasculature maturation.
Researchers found a natural way to enhance antibiotic action by combining maple syrup extract with commonly used antibiotics. This approach works on various bacterial strains, including E. coli, Proteus mirabilis, and Pseudomonas aeruginosa, allowing for up to 90% less antibiotic use while maintaining effectiveness.
Research published in ENDO 2017 found that patients with more severe heart failure are associated with higher TSH and T4 levels, lower T3 levels, and increased risk of needing mechanical assistance or death. Subclinical hypothyroidism is also linked to worse survival outcomes.
Astronomers discover enigmatic flash of X-rays from galaxy 10.7 billion light years away, exhibiting properties unlike known gamma-ray bursts or stellar destruction; scientists struggle to understand its origin and potential implications for compact star mergers.
Researchers at Aalto University have made significant progress in recycling and upcycling clothing to create high-quality textiles. They discovered an ionic liquid that can dissolve cellulose from wood pulp and cotton-polyester blends, producing fibers stronger than commercially available viscose.
A new survey finds that nearly a quarter of transgender individuals in Toronto regard their fertility as important, yet most lack knowledge about reproductive options. Early discussions with healthcare professionals may improve awareness and access to these options.
A new study sheds light on the dark side of tumor suppressor gene p53, revealing that regulating genes Mdm2 and Mdm4 keep mutated p53 in check. The study shows that mutating these proteins can lead to an elevation of mutant p53, driving cancer growth.
Researchers use bee-venom peptide apamin to develop a novel strategy for delivering medications to the brain. They modified apamin to eliminate toxicity while maintaining its ability to cross the blood-brain barrier, resulting in a promising version called Mini-Ap4.
A new measurement technique has reanalyzed vitamin D levels and lowered the estimated Recommended Dietary Allowance (RDA) from 800 to 400 International Units (IU) per day. This change may have significant public health implications, with easier-to-achieve daily intake of 400 IU recommended.
Researchers have developed two new blood tests that can reliably detect previously unidentifiable forms of melanoma, a type of aggressive skin cancer. The tests use DNA fragments in the blood to monitor tumor growth and can detect changes in genes that help cancer cells multiply.
A study by the University of Pittsburgh Cancer Institute found that higher levels of tumor-associated immune cells and certain T cell types are associated with better response to immunotherapy. This could lead to more effective treatments for patients with recurrent head and neck cancer.
A study of 9,231 individuals found that those with higher free thyroxine (FT4) levels had an elevated risk of atherosclerotic morbidity and mortality independent of cardiovascular risk factors. Higher FT4 levels were also associated with greater risk of subclinical atherosclerosis.
Thyroid cancer incidence has increased in the US, with higher rates among Hispanics and African Americans compared to non-Hispanic Whites. The study found a significant rise in incidence among young people, particularly Hispanic females between 20-49 years old.
A study by the Endocrine Society found that higher exposure to certain flame retardants may be associated with an increased risk of papillary thyroid cancer. The researchers collected dust samples from homes and analyzed participants' blood samples to assess long-term exposure to these environmental chemicals.
Researchers at the University of North Carolina Lineberger Comprehensive Cancer Center have discovered a potential novel strategy for improving immunotherapy treatments against cancer. By binding two compounds to a nanoparticle, they were able to improve stimulation of T-cells and increase survival rates in preclinical models.
Research reveals that consuming cow's milk with levothyroxine supplement can lead to reduced absorption of the medication, potentially resulting in inadequate thyroid hormone levels. The study advises patients on managing hypothyroidism or taking levothyroxine to avoid consuming dairy products simultaneously.
Research suggests that early-life BPA exposure can lead to fatty liver disease by reprogramming gene expression. The study found that BPA creates new activating epigenomic marks on genes driving the progression of NAFLD in rats.