Researchers discovered a protein-cleaving enzyme called FAP that plays a role in shaping the physical nature of the stroma, promoting tumor growth and metastasis. Deleting or inhibiting FAP in mouse models of pancreatic cancer slowed disease progression and reduced cancer spread to other organs.
By analyzing regulatory networks for 38 tissues, researchers found that core components are combined differently with added genetic and environmental information, governing unique tissue functions. This work emphasizes the need to consider tissue context when developing therapies to minimize potential side effects.
Researchers at the University of Basel have identified a microRNA that inhibits epithelial-mesenchymal transition (EMT), a process linked to tumor cell spread and metastasis. This discovery may lead to new treatment approaches for breast cancer.
Researchers developed software using machine learning to analyze EEG signals from preterm infants, providing an estimate of brain functional maturity. The method is more precise than current methods and enables automatic monitoring of premature infant brain development.
A Stanford University School of Medicine study found that frequent marijuana users had increased coital frequency compared to non-users. The study analyzed data from over 50,000 Americans aged 25-45 and found a positive association between marijuana use and sexual activity across all demographics.
Researchers at Virginia Commonwealth University have designed solid-state electrolytes that are as conductive as their liquid counterparts while being very stable. This breakthrough could enable the creation of safer and more powerful lithium-ion batteries.
Researchers found that CO2 sublimation can create unique features on Mars, such as Sand Furrows and linear gullies. These processes are unlike anything seen on Earth and provide new insights into Martian geomorphology.
Researchers discovered that fish respond emotionally to their environment, with brain areas linked to positive and negative emotions activated. The study suggests a simpler neurologic basis for emotional assessment than expected, potentially evolving around 375 million years ago.
CancerLinQ is a big-data, real-world health information technology system that enables near real-time access to individual patient data for informed decision-making. The platform allows practitioners and researchers to tap into longitudinal, de-identified data and analytics.
Two new medications have been approved to treat mild, moderate, and severe eczema in both children and adults. Crisaborole reduces itching, redness, and swelling, while dupilumab targets the underlying cause through injection therapy. These treatments provide effective relief and improve quality of life for those affected by eczema.
A recent study published in HeartRhythm found that blacks have a lower risk of atrial fibrillation compared to whites, despite having similar risk factors. The research suggests that the frequency of early beats in the atria, known as premature atrial contractions, may be heritable and explain the racial differences in AF rates.
The South Carolina Cancer Disparities Research Center aims to understand the reasons behind racial and ethnic health disparities in cancer research. The center will increase SCSU's ability to conduct cutting-edge research, inspire new generations of researchers, and engage the general public in cancer research.
A recent study found that populations of Plasmodium vivax in the Americas are as genetically diverse as those in Southeast Asia, contradicting previous assumptions. The research suggests that P. vivax may have originated from Africa, Europe, and Asia, and its genetic diversity was retained upon arrival in the Americas.
A new study suggests a significant increase in childhood peanut allergies in the US, with rates rising 21 percent since 2010. Nearly 2.5 percent of U.S. children may have an allergy to peanuts, and black children are disproportionately affected.
Tropical Storm Selma has high potential for heavy rainfall due to very cold cloud top temperatures, posing life-threatening flash floods and mudslides. The storm is expected to make landfall in western El Salvador on Saturday night, October 28.
A study published in Nature Communications suggests that peatland plants are better adapted to climate change than previously thought. Despite rising temperatures and changing atmospheric conditions, the plant community in peatlands can replace missing species with new ones having similar functions.
Scientists have identified a novel pathway that protects mitochondria from toxic protein aggregates, reducing cellular energy production. The mitoRQC pathway, involving the cytosolic protein Vms1, regulates aberrant protein fate and maintains cellular homeostasis.
Scientists have now shown that individual neurons in the mouse brain often spool out spindly fibers nearly half a meter long. The team's dataset and analysis tool, MouseLight NeuronBrowser, offer new insights into how elaborately-branching neurons route information in the brain.
Researchers found that urinary incontinence medications were nearly six times more likely to cause dry mouth than a placebo. Healthcare providers should regularly monitor for potential side effects and adjust doses or change medications when necessary.
A two-week high-intensity interval training (HIIT) program reduced glucose metabolism in all areas of the brain in physically inactive individuals with prediabetes or type 2 diabetes. HIIT improved whole-body insulin sensitivity, and moderate exercise also showed similar benefits.
Researchers at University of Innsbruck have successfully levitated nanomagnets using quantum physics, exhibiting stability and entanglement properties. This breakthrough defies the classic Earnshaw theorem and opens new avenues for studying exotic quantum phenomena.
Researchers discovered that bacteria use pili as their sense of touch when interacting with surfaces, leading to a new understanding of bacterial surface sensing. This mechanism may help scientists develop strategies to control bacterial growth, either beneficially in bioreactors or pathogenically on medical devices.
Research finds that restored, protected reefs have significantly higher oyster densities and larval output compared to harvested reefs. Additionally, restored harvested reefs show increased larval recruitment, implying a valuable spillover effect from reserves to surrounding areas.
A study by Indiana University researchers suggests that reviving the coal industry will have little impact on fragile Appalachian communities. Instead, they found that promising jobs may fill communities with false hope, threatening progress in launching job training programs and other transition steps.
A survey of 100 patients found that Facebook was the most used and engaging platform, with Instagram second, while YouTube and Pinterest had low engagement rates. The practice's website was the go-to source of online information, influencing over half of patients' decisions.
Researchers at Bielefeld University developed Narrative Exposure Therapy (NET), a successful treatment method for refugees with mental problems. The therapy involves storytelling to process traumatic events in a meaningful context, leading to closure and reduced symptoms.
A national study has launched mobile stroke units, which bring highly trained personnel and advanced medical equipment to patients in need of rapid treatment. The units have shown promise in improving patient outcomes and efficiency, with the potential to enable faster diagnosis and treatment of strokes.
Researchers have developed a comprehensive genomic sequencing approach that guides timely treatment for recurring brain cancer, resulting in extended progression-free survival. Two patients survived over a year without disease recurrence, demonstrating the potential of precision medicine in aggressive and refractory tumors.
Researchers analyzed 560 European peat bog samples to study how they respond to different temperatures, precipitation levels, and air pollution. They found that functional redundancy allows the ecosystem to survive despite changing species due to climatic conditions.
Researchers used ultra-high field fMRI to map brain pathways in patients with amputations who underwent TMSR. The study found that the brain's motor and somatosensory maps were preserved, but connections with higher-level embodiment regions were weak. Future prosthetics should implement systematic somatosensory feedback to enable patie...
Two INRS professors, Shuhui Sun and Federico Rosei, received international recognition for their groundbreaking work on novel materials. Their research focuses on developing renewable energy technologies, with Professor Rosei's discoveries leading to improved solar panels.
Eindhoven University of Technology has implemented significant reforms in its engineering education, introducing a three-course series that teaches patents and standards to improve students' critical thinking skills. The changes resulted in a significant increase in student intake, with over 1,900 students enrolled by 2015.
A recent study revealed that only 11 percent of pediatricians follow guidelines for introducing peanut-containing products to infants to prevent allergies. High-risk babies, those with egg allergy and/or severe eczema, are not being referred for testing prior to introduction.
A study found low public awareness of atrial fibrillation (AF), with only 48% globally aware, but 82% correctly identifying palpitations as an AF symptom. The estimated 33.5 million people worldwide live with AF, highlighting the need for increased public health initiatives.
The publication of the buffalo genome provides essential reference point for studies on molecular genetics, helping breeders enhance desirable characteristics and researchers preserve diversity. A molecular tool, Buffalo SNP chip, has been developed to apply modern molecular breeding systems to water buffalo.
Researchers have developed a sustainable 3D printing process using polyethylene-2,5-furandicarboxylate (PEF), a polymer made from cellulose. The new biobased polymer allows for high-quality objects with good solvent resistance and thermal stability.
A new study by the American College of Allergy, Asthma, and Immunology found that almost half of adult food allergies occur in adulthood, with shellfish allergy prevalence increasing by 44% among US adults. The risk of developing a food allergy to certain foods is higher among black, Asian, and Hispanic adults compared to whites.
Researchers at Drexel University have identified microRNA miR-34a as the 'master regulator' involved in bronchopulmonary dysplasia (BPD), a chronic lung disease affecting up to 15,000 premature infants annually. Inhibiting miR-34a significantly reduces BPD in mice, suggesting a potential new treatment target.
A new study reveals that protected areas of tropical forest are reducing carbon emissions by a third, and slowing the rate of global warming. The research found that these protected areas prevent the release of three times as much carbon into the atmosphere as the UK emits each year.
Researchers at Arizona State University have discovered that proteins can conduct electricity like metal through a new technology called recognition tunneling. This finding has potential applications in medical diagnosis and could revolutionize the way we understand protein behavior.
A study characterises the clinical, physical, physiological and dietary patterns of the overweight/obese population with primary hypertension. The researchers found that a profile of high cardiovascular risk includes hypertension diagnosis, excess weight/obesity, poor cardiovascular fitness, and unhealthy dietary habits.
Researchers have developed a novel laboratory model that replicates key hallmarks of pediatric high-grade glioma, a devastating illness and leading cause of death in children. Mutations in histone 3.3 are believed to play a pivotal role in its development, with the new model supporting the concept that cancer starts in utero.
A University of Maryland-led study developed a vaccine candidate that stimulates an immune response against the protective sugars of multiple HIV strains. The molecule mimics a protein-sugar part of the shield and spurs rabbits to produce antibodies, but does not prevent live HIV from infecting cells.
Two studies present evidence suggesting that exposure to dogs during pregnancy and early childhood may reduce the risk of developing eczema and asthma. While exposure to dog allergens can exacerbate symptoms in children with allergies, non-allergen-related factors associated with dogs may provide a protective effect.
The Concise Guide to PHARMACOLOGY 2017/18 simplifies drug discovery research by providing overviews of key properties for human drug targets. The guide features over 4,000 interactions between ligands and targets, allowing researchers to assess potency.
The University of South Florida's special issue highlights international efforts to promote innovation outputs through new university courses, curricula, and programs. Key findings include the importance of IP management in universities' curricula, as well as innovative approaches to teaching engineering and business skills.
The American College of Allergy, Asthma, and Immunology is developing guidelines for allergists on using telemedicine to provide high-quality care. This approach leverages technology to improve access to medical care and maximize patient experience. The goal is to have an exceptional user experience, putting the patient at the center.
NASA's Global Precipitation Measurement mission observed strong storms and heavy rainfall on Tropical Storm Saola, with rain rates exceeding 66 mm per hour in feeder bands. The storm showed significant structural improvement over the course of several hours, with peak intensity predicted for the following day.
A pilot study found Montmorency tart cherry juice significantly extended sleep time among senior insomniacs by 84 minutes. The study also showed reduced plasma levels of kynurenine with increased tryptophan levels, and inhibition of PGE2, a biomarker of inflammation.
A study found that children with eczema and a family history of asthma had more severe hospital experiences, including increased oxygen use and longer stays. The research suggests these factors may help identify children at higher risk for severe asthma hospitalizations.
A study found that men aged 65+ who survived an ischemic stroke are 3x more likely to be placed in a nursing home within 5 years if they lack a caregiver. The lack of caregivers puts older adults at risk of losing independent living.
Researchers discovered that Zika virus is transmitted from mother to fetus by infected microglia cells, which later develop into the brain's defense system. The finding suggests a potential therapeutic target for reducing Zika transmission and offers hope for preventing devastating neurological damage.
A Florida State University researcher challenges the idea that modern civilization reduces violence by arguing it may actually increase the likelihood of surviving a war. Studies on chimpanzees and human societies show that larger populations lead to more deaths in conflicts.
A study by the Cluster of Excellence found that European Muslims have a more positive view of the EU compared to other groups. This is largely due to their satisfaction with living conditions and higher political interest. The study also highlights the importance of successful integration in maintaining trust in EU institutions.