Researchers used an experimental therapy to block fibronectin protein, reducing scarred muscle tissue and saving mouse models from heart failure. The treatment restored function in damaged heart cells and reduced fibrosis.
A study published in the International Journal of Cancer found that regularly eating red meat increases the risk of distal colon cancer in women, with those on a red meat-free diet experiencing lower rates. The research suggests that a diet free from red meat significantly reduces the risk of this type of colon cancer.
A new study found that losing one night of sleep led to an increase in beta-amyloid, a protein linked to Alzheimer's disease. The study also showed that participants with larger increases in beta-amyloid reported worse mood after sleep deprivation.
NGM282, an engineered analogue of FGF19, inhibits bile acid synthesis and decreases markers of hepatic inflammation in patients with primary sclerosing cholangitis. Significant reductions in serum levels of ALT and AST were observed in the NGM282 3 mg/day treatment group.
The study confirms that long-term OCA treatment leads to reversal or stabilization of fibrosis/cirrhosis in patients with primary biliary cholangitis (PBC) who have had an incomplete response to ursodeoxycholic acid (UDCA). The majority of patients improved or maintained their histological stage, while two patients deteriorated.
Researchers at the University of Huddersfield have found that tungsten, a favored metal in nuclear fusion reactors, becomes brittle due to radiation damage. This discovery hinders the use of tungsten as a structural material, prompting the development of new alloys that can prevent embrittlement.
A national survey by Kessler Foundation reveals that 69% of people with disabilities are striving to work, overcoming barriers through job preparation and negotiation. The study also finds that many employees report experiencing and successfully addressing obstacles such as negative attitudes and pay disparity.
A new study found that extreme cold increases mortality and morbidity risks for people with cardiovascular and respiratory diseases, while extreme heat is risky for those with renal diseases. The research aims to develop tailored public service risk communication strategies.
Professor William Lee's research uses mathematical modeling to investigate topics such as Guinness bubbles and filter coffee machines. His work has led to the development of a mathematical model for coffee brewing that can aid machine design, and he is now exploring the link between strength and flavor in espresso.
A new study reveals increased risks for Alzheimer's disease and suicidal tendencies among children and young adults living in polluted cities. Researchers detected abnormal proteins indicative of the disease as early as infancy, highlighting the need for preventative measures.
Research by the University of Exeter and the British Trust for Ornithology found that people in crowded urban areas see fewer songbirds but more nuisance birds. In contrast, green and leafy suburbs have up to three and a half times more songbirds and woodpeckers, associated with positive human wellbeing.
Researchers Gary Lewin and Norbert Hübner are investigating the molecular mechanisms underlying neurological and heart diseases. They hope to identify ion channel anchors and characterize them at the molecular level, laying the groundwork for therapies that address tactile disorders and heart failure.
Researchers at UCR have isolated three new bacterial species from wild bees that may inhibit fungi growth in pollen provisions. These Lactobacillus strains could help preserve nectar and pollen for larvae, promoting bee health.
Researchers found that over one-third of patients denying a self-inflicted gunshot wound were likely trying to kill themselves. Hospitalized patients who denied a suicide attempt were nearly 11 times more likely to be discharged without inpatient psychiatric care. Brief psychological interventions can improve treatment outcomes.
A new study has reported a good correlation between an automated image analysis system and an expert reviewer for the identification of key markers of NASH disease activity in a pre-clinical model. The study used deep-learning algorithms applied to open-source pathology software (QuPath1) to accurately identify cell histology patterns ...
Two nationwide hepatitis C elimination programs in Georgia and Iceland have reported high levels of engagement, initiation of direct-acting antiviral agents, and cure among patients chronically infected with HCV. In Georgia, over 90% of diagnosed individuals were cured, while in Iceland, the prevalence of active HCV infection among peo...
Researchers at the University of Pittsburgh have developed a novel 'Tic-tac-toe' RF coil system for high-resolution brain imaging, addressing technical difficulties associated with ultrahigh field human MRI. The technology enables better understanding of neurological diseases such as depression, Alzheimer's disease, and schizophrenia.
The Hubble Space Telescope has imaged a massive galaxy cluster, revealing its intricate structure and the presence of dark matter. The cluster is comprised of thousands of galaxies held together by gravity, with most of its mass existing in non-luminous dark matter.
Researchers have successfully entangled 20 calcium atoms in an ion trap experiment, demonstrating controlled multi-particle entanglement between neighboring groups of particles. The achievement holds significant promise for practical applications such as quantum simulations and information processing.
Researchers at Friedrich Schiller University Jena have successfully created tailored surface structures on curved carbon fibers using laser technology, enabling new applications in composite materials and optical devices. The method allows for precise control over the structure's size and shape, opening up possibilities for improving m...
A study published in Malaria Journal found that ambient temperature impacts the toxicity of commonly used insecticides against malaria vectors. The researchers explored the effect of temperature on pyrethroid and carbamate insecticides, revealing that temperature affects their efficacy differently for resistant and susceptible strains.
Researchers used the world's most powerful X-ray source to study fuel injection and combustion in a gas turbine engine. The data gathered will help advance gas turbine engine designs for higher power density and efficiency.
Researchers at NIST have developed a nanoscale coating for solar cells that absorbs up to 20% more sunlight, increasing efficiency and reducing costs.
A real-world study found that patients with chronic hepatitis C virus infection who achieve a sustained virological response (SVR) after direct-acting antiviral agent (DAA) treatment have lower all-cause mortality. Achieving SVR reduced mortality from both liver-related and unrelated causes at all stages of disease.
Researchers at MIT and Brigham and Women's Hospital have developed biocompatible gels for drug delivery using caffeine as a catalyst, eliminating the need for hazardous metal catalysts.
Researchers shed light on functional mechanism of ABC exporters, which transport a wide range of molecules out of cells. This understanding could lead to new therapeutic approaches by specifically influencing or inhibiting these processes.
Researchers at NUST MISIS developed a theory explaining how latent state formation occurs in layered tantalum disulfide, leading to ultra-fast memory capabilities. The material's nano-structural mosaics and charged vacancies contribute to its switching and memory effects.
Rice University scientists introduce a new technique to fine-tune two-component biological sensors, enabling tailor-made biosensors for diagnostic gut bacteria and environmental pollutant detection. The approach uses phosphatase activity to alter the sensitivity of these pathways, promising a major breakthrough in synthetic biology.
A nationwide US study confirms a significant decrease in liver transplant probabilities for HCC patients between 2005-2007 and 2014-2016. Patients with Medicaid insurance were less likely to receive transplants than those with private/commercial insurance.
Researchers are working to identify biomarkers for food allergies, aiming to improve understanding of how children's immune systems react to certain foods. Current blood tests are only 30-55% specific, leaving room for further innovation in diagnostics and treatments.
A well-controlled trial found that omega-3 fatty acid supplements taken orally proved no better than placebo at relieving symptoms or signs of dry eye. Despite insufficient evidence establishing the effectiveness of omega-3s, clinicians and patients have been inclined to try the supplements for various conditions, including dry eye.
Researchers developed a powerful mouse model using CRISPR-Cas9 and RCAS/TVA system to mimic glioma genetic alterations. The model enables the study of gene fusions and mutations in cancer progression and treatment response.
The study, funded by the National Eye Institute, tested oral omega-3 supplementation on patients with dry eye disease. Despite finding some improvement in symptoms and signs, researchers concluded that omega-3 supplements did not show a beneficial effect relative to placebo.
A study found that budesonide add-on therapy improves biochemical markers of disease activity but fails to improve liver histology in high-risk patients with primary biliary cholangitis. Budesonide was shown to produce clinically meaningful improvements in serum alkaline phosphatase levels.
A recent study published in the American Journal of Preventive Medicine found that racial minority adolescents have a high prevalence of substance use and are at a higher risk for suicidal thoughts and behaviors. The research team analyzed data from over 20 years of national surveys and found that Pacific Islander, multiracial, and Ame...
A new study reveals that extreme climate variability over the last century has synchronized ecosystem behavior on the West Coast, increasing risks of extinction for marine and terrestrial organisms. This synchrony is linked to changes in winter climate patterns, such as the North Pacific High, which have become more variable over time.
The percentage of liver transplants performed due to HCV infection has more than halved since the introduction of direct-acting antiviral drugs. Post-transplant survival rates among those with HCV infection are now similar to those with HBV infection, reaching an all-time high.
The OU mathematics department will use a $3 million NSF grant to study active learning methods for improving STEM student success. The project aims to develop models that work at any institution, with a focus on helping underrepresented minority students succeed in introductory math courses.
A team of scientists has developed a machine learning algorithm that can quickly identify new blends of ingredients for metallic glass, accelerating the discovery process by 200 times. The method uses data from thousands of experiments to pinpoint potential materials and has significant implications for the future of materials science.
The University of Texas at Arlington has received a $318,778 grant to create a campus-wide assistive technology program. The program will teach undergraduate students how to design assistive technology to help reduce barriers faced by people with disabilities.
Researchers use ultra-cold neutral lithium atoms to study conductivity in a one-dimensional quantum tube. They discover an unusual state of matter that retains its insulation regardless of particle interactions, challenging conventional theories about materials.
A study analyzed outcomes and costs for German patients with NAFLD/NASH who developed compensated cirrhosis, finding significant increases in comorbidities, mortality, and healthcare costs. The study highlights the need for new treatment options to improve patient outcomes.
A team of scientists has developed a method to discover new metallic glass alternatives using machine learning and accelerated experiments, reducing the discovery time from decades to hours. The approach enables researchers to quickly narrow down potential materials and get immediate feedback from AI models.
Pancreatic cancer cells rely on autophagy for fuel, a process that can be blocked with an ERK inhibitor. Researchers at UNC Lineberger Comprehensive Cancer Center report a synergistic effect when combining the ERK inhibitor with a compound that blocks autophagy to starve cells completely.
A multi-university study is mapping the repeated evolution of similar head shapes among animals using their heads to dig into the ground. The researchers aim to understand how anatomy, development, relationships, and ancestry influence body shape, examining over 400 million years of evolution.
A new study found that brief exposure to fine particulate matter PM2.5 is associated with the development of acute lower respiratory infection (ALRI) in young children, leading to increased doctor visits and hospitalizations. The research suggests that air pollution may impair the body's ability to fight off infections or cause damage ...
Patients with NAFLD achieved similar weight loss and normalized liver enzymes through a web-based lifestyle modification programme. The study suggested that the degree of weight loss was likely to have resulted in fibrosis regression.
Research found that acute lower respiratory infection (ALRI) is associated with elevated levels of fine particulate matter PM2.5 in young children, even those as young as two months old. The study, involving over 100,000 patients, suggests that air pollution may impair the immune response and increase susceptibility to infections.
Researchers from NICT and Fujikura successfully demonstrated a transmission experiment over 1045 km with a data-rate of 159 Tb/s using a 3-mode optical fiber. This achievement sets the world record for a standard outer diameter few-mode optical fiber, surpassing previous records by about twice.
The Chinese observation satellite TanSat has produced its first global carbon dioxide maps, providing valuable data for future climate change research. The maps show a seasonal decrease in carbon dioxide concentration from spring to summer in the Northern Hemisphere and emission hotspots due to anthropogenic activity.
Researchers at the University of Huddersfield will conduct exhaustive tests on a lightweight carbon fiber rail bogie frame, which could lead to significant savings for operators. The project uses recycled carbon fibers to reduce weight by up to 50% and track wear, resulting in lower maintenance costs.
A team of physicists has successfully imaged individual impurity atoms in graphene ribbons using atomic force microscopy. The technique allowed them to identify boron and nitrogen atoms, expanding graphene's properties for applications like transistors and circuits.
The SORAMIC study found no overall survival benefit of adding selective internal radiation therapy (SIRT) to sorafenib for patients with unresectable primary liver cancer. However, subgroup analyses suggested possible survival benefits in younger patients and those with certain cirrhosis characteristics.
Researchers at Peter the Great St. Petersburg Polytechnic University developed a computational method predicting harmful mutations in mammalian species. This approach enables classification of damaging mutations in other mammals, facilitating optimized animal breeding programs.
Research by Lobachevsky University and Moscow State University found that cytoplasmic streaming is involved in the transmission of signals within giant cells of Chara algae. The study showed that signal molecules formed in illuminated areas propagated with the moving cytoplasm, affecting photosynthesis and enhancing fluorescence in oth...
University of Alberta researchers develop a new guide molecule, bridged nucleic acid (BNA), to improve the accuracy of gene-editing technology. The BNA is shown to be much more stable and stringent in finding the correct DNA sequence to cut, promising to bring gene-editing closer to therapeutic reality.
Scientists investigate TRPV1 receptor, found in immune cells, as potential target for TBI recovery. Activating TRPV1 may balance macrophage populations and promote M2s, reducing lingering inflammation and improving cognition.
A new randomized clinical trial found that omega-3 fatty acid supplements were no more effective than placebo in alleviating dry eye symptoms. The study enrolled 535 participants and revealed that even the highest dose of omega-3 supplements did not improve outcomes for participants.
A study by University of Toronto researchers found that a specific region of the hippocampus may play a key role in emotional regulation, including anxiety. The discovery challenges current thinking on how this part of the brain processes information.
A University of Seville study found that family support networks in Peruvian barrios play a crucial role in preventing child labor. The networks facilitate the exchange of information and social support between families, which helps control child labor. Schools serve as hubs for these relationships, bridging gaps to external resources.
Scientists have created a universal qubit design that can be used to build a quantum computer. The new superconductor qubit is based on a continuous superconducting nano-wire and has proven to be no worse than traditional designs in initial experiments.
Anne Quarshie's dissertation explores how firms can bring about transformational change in sustainability and corporate social responsibility. She is the first Finnish recipient of the IPSERA Doctoral Dissertation Award, recognizing the high quality of her research on responsible supply chains and disaster preparedness.
A study led by researchers at Linköping University found that amyloid beta, a protein linked to Alzheimer's disease, has different properties in different cell types. Glial cells can produce mature, less harmful forms of the protein, while neurons are more susceptible to damage.
Phase 2 studies of tropifexor and seladelpar demonstrate potent anti-cholestatic and anti-inflammatory activity without increasing pruritus. Tropifexor and seladelpar are being explored as potential treatments for patients with primary biliary cholangitis, a progressive liver disease.
The University of Oklahoma Advanced Radar Research Center is developing new antenna and related technologies for the US Navy's next-generation radar systems. The team aims to improve agility and multi-functionality, enabling future implementation on various surfaces and platforms.
The European Genome-Phenome Archive (EGA) stores nearly 4,000 genomic datasets, facilitating research into cancer, cardiovascular and rare diseases. The EGA enables cooperation among scientists, accelerating medical genomics in Spain.
Researchers developed a coordinated control architecture for motion management in ADAS systems, demonstrating improved safety and comfort. The study showed that 'coordinated control' strategy successfully damped out deviation errors, giving much greater precision in following intended trajectories.
Research published in City and Community found that straight people living in traditionally gay neighborhoods often practice subtle forms of discrimination against their gay and lesbian neighbors. Despite claiming to support gay rights, many interact with their neighbors on the street in ways that contradict those sentiments.
Researchers at Texas A&M University have discovered a new class of clay nanoparticles that can direct human stem cells to become bone or cartilage cells. These nanoparticles, similar to flaxseed in shape, can grow tissue from stem cells in the absence of growth factors.
A novel process called Friction Stir Dovetailing joins thicker aluminum alloys to steel, creating joints of superior strength and ductility. The technique inhibits intermetallic compound overgrowth, allowing for improved fuel efficiency and operational effectiveness in military combat vehicles.