A UAB-led study published in The Lancet Diabetes & Endocrinology found that denosumab was superior to risedronate in increasing bone density in patients with glucocorticoid-induced osteoporosis. The 12-month study enrolled 795 patients and showed promising results for the new drug.
Researchers recover intact human mitochondrial DNA from common type of plant-based artifact, providing insights into the genetic ancestry of Native Americans in the Desert Southwest. The study also sheds light on the Numic Spread event, a contentious debate among scientists.
Researchers verify anomalous amplitude apodization for non-spherical particles, boosting microscope magnifying power and peak field intensity. This technique enhances imaging capabilities for biological molecules, viruses, and living cells.
The U.S. Small Business Administration has renewed the Veterans Business Outreach Center grant at the University of Texas at Arlington for $1.375 million over five years. The grant supports education, training, and consulting services for veterans starting or growing businesses in North Texas, Oklahoma, and Arkansas.
Scientists at the University of Cambridge have identified N-acetyltransferase 10 (NAT10) as a potential therapeutic target for Hutchinson-Gilford Progeria Syndrome (HGPS), a rare condition that causes premature ageing. In a mouse model, chemical inhibition or genetic deregulation of NAT10 led to significant health and lifespan gains.
Researchers at UTHealth and Ohio State University combined virotherapy with boosting the natural immune system to fight cancer. The study found that increasing the number of externally added NK cells strengthens the ability to fight cancer.
Research identifies a mechanism by which glioma cells develop resistance to anti-angiogenic treatment, using different strategies to spread through the brain. The study reveals a potential target for combination therapies based on Wnt signaling and vessel co-option pathways.
The American Academy of Sleep Medicine has selected several individuals for its 2018 awards, including Dr. Jack D. Edinger and Naresh M. Punjabi, who received the Nathaniel Kleitman Distinguished Service Award and William C. Dement Academic Achievement Award respectively. Arianna Huffington also received the Mark O. Hatfield Public Pol...
A study published in the Journal of Advertising Research found that both Black and White teens perceive Black-oriented media as being targeted towards them, suggesting the potential for increased profitability when marketed to a broader audience. The study surveyed 1,900 adolescents ages 14-17 about their movie preferences.
The AVIATOR 2 international registry found significant discrepancies between physician-perceived risks and calculated scores for stroke, ischemic risk, and bleeding in patients with AF undergoing PCI. The study used a novel smartphone-based survey to capture physician and patient perspectives on antithrombotic therapies after PCI.
Researchers discovered that a multiple sclerosis drug can mitigate the painful side effect of cancer treatment bortezomib. Fingolimod, an approved multiple sclerosis medication, blocks the production of molecules causing nerve damage and alleviates neuropathic pain.
A study analyzed online reviews of over 1,000 plastic surgeons on Google, Yelp, and RealSelf, finding that positive reviews were more likely to mention good bedside manner and surgeon expertise. Negative reviews often cited disappointment with cosmetic results or perceived rudeness from the surgeon.
Scientists at Helmholtz Zentrum München have identified 16 virus structures that can be attacked by killer T cells, which could lead to new therapies for immunocompromised individuals and patients with autoimmune diseases. The researchers discovered these targets using an algorithm and verified them in a large group of patients.
A team of renewable energy experts at the University of Exeter has developed a new method to produce hydrogen from sunlight using a revolutionary photo-electrode. This breakthrough could create a virtually limitless energy source with zero carbon emissions and double the energy density of fossil fuels.
Swansea University's METaL scheme has received £1.4m EU funding to increase skills in the advanced manufacturing sector. The additional funding will enable the scheme to support over 400 people in gaining technical skills, with a focus on emerging sectors such as energy and smart manufacturing.
Researchers found that music activates the salience network of the brain, which remains relatively functioning in individuals with Alzheimer's disease. The study suggests that personalized music programs may be an alternative route for communicating with patients who have lost contact with their environment.
Talin and α-catenin proteins unfold through stable 3-helix intermediates, enabling recruitment of other binding partners and regulating protein function.
Scientists have engineered red blood cell lines to express fewer antigens, making them less immunogenic for patients with rare blood types. This breakthrough could lead to the development of more universal blood sources for transfusion patients.
The PERSPECTIVE trial presents a comprehensive review of the safety, efficacy, and durability of Zotarolimus-Eluting Stents in treating chronic total occlusion. Treatment with second-generation drug-eluting stents resulted in lower occurrence of adverse events compared to previous DES trials.
Researchers used stable carbon and oxygen isotope analysis to show that some individuals subsisted primarily on forest resources, while others relied on agriculture through trade. The study's findings are significant for the Wanniyalaeto people's battles to remain on their traditional hunting grounds.
New research estimates total and per-case costs of newly diagnosed non-melanoma skin cancers in Canada in 2011 due to workplace sun exposure. The study found that the two most common types of non-melanoma skin cancer cost $5,760 and $10,555 per case respectively.
A global project is underway to map every type of cell in the human body as a resource for investigating health and disease. Penn bioinformatics researcher Casey Greene will use this funding to develop open, shared computational tools and algorithms to analyze large data sets without being instructed what features to look for.
A smartphone video-based app substitutes for in-person daily visits required for tuberculosis treatment, with patients showing similar adherence rates as traditional DOT. The app offers a more private and cost-effective option for monitoring medication intake, but further research is needed to assess its full impact.
A new study analyzing patients with mixed drug abuse and endocarditis found a significant increase in hospitalizations over the last decade. The study estimated substantial healthcare costs, with a total of $17.3 million billed by the hospital in 2015 alone.
A new study finds that older adults with severe hearing loss who use hearing aids are less likely to visit the hospital or emergency room, despite high costs of the devices themselves. The association is significant, even considering factors such as income and education level.
Researchers analyzed the survivability of RNA-containing viruses, discovering that inaccurate genetic copying helps them adapt to adverse conditions. The study found that viruses can repair damaged elements or evolve new properties to compensate for damage, ensuring their survival and persistence.
A study found that New York City firefighters exposed to the 9/11 World Trade Center disaster site are at an increased risk for developing myeloma precursor disease, which can lead to the blood cancer multiple myeloma. The prevalence of MGUS was nearly twice as high in firefighters compared to a non-exposed group.
A recent study published in Cell Host and Microbe found that bacteria in the small intestine play a vital role in fat digestion and absorption. The researchers discovered that high-fat Western diets stimulate the growth of beneficial microbes in the small intestine, which then produce digestive enzymes to break down dietary fat.
Researchers have developed a control algorithm that regulates electrical current to provide steady sensation in prosthetic arms. The system reduces painful shocks and improves user experience, enabling users to feel touch and pressure, even with electrodes peeling off or sweat building up.
A 2017 Mw 5.4 Pohang earthquake in South Korea is believed to have been triggered by fluid injection at a nearby Enhanced Geothermal System (EGS) site, the largest-induced quake ever recorded at an EGS location.
PARP-1 levels are linked to targeted therapy resistance in ovarian cancer. Researchers have developed a method to image and measure PARP-1 using PET scans, which may predict efficacy and resistance to PARP inhibitors.
Archaeologists discovered evidence of ancient Neolithic communities using fungi as tinder to start and transport fires at the La Draga site. Researchers analyzed a unique set of remains, finding six fungal species used for this purpose, including Daedalea quercina and Coriolopsis gallica.
The Christian Doppler Lab for the Direct-Write Fabrication of 3D Nano-Probes focuses on novel 3D printing technology. The CD lab for Location-Aware Electronic Systems explores radio-based positioning systems for applications where satellite systems are not available.
Cadm1 protein interacts with Kaposi's sarcoma viral proteins to promote inflammation and cancer growth in KSHV-infected cells. This discovery could lead to a new therapy targeting human protein CADM1 in viral-mediated cancers.
A study led by Rutgers University scientists has found that a fungus causing devastating rice disease became harmful 21 million years ago. The researchers identified key genes and proteins that promote the infection process, offering insights into developing new fungicides and quarantines to combat crop diseases.
Researchers at the University of Birmingham have discovered a unique mechanism driving the spread of Cryptococcosis, a rare and deadly fungal infection. The 'division of labour' process relies on extracellular vesicles to coordinate behavior between individual fungal cells.
The VA health care system performs similarly to or better than non-VA systems on most measures of inpatient and outpatient care quality, according to a new study. The findings suggest that the VA needs targeted quality improvement efforts to ensure uniform high-quality care at all facilities.
A Japanese research team has uncovered new molecular details and provided a model explaining how stepwise flagellar assembly occurs in bacteria. The proposed model suggests that subtle changes in the ring's shape determine which proteins are exported to the growing flagellum, enabling its construction.
Researchers have developed a system to profile every cell in developing zebrafish and frog embryos, revealing the comprehensive landscape of gene expression events that mark new cell states and types. This work provides a significant resource for studying developmental biology and disease.
A large-scale study of thyroid cancer genetics has identified specific genes driving the disease and found that certain cancers can benefit from immunotherapy. The research also found amplifications of key receptor tyrosine kinases in anaplastic thyroid cancers, suggesting a potential target for treatment with lenvatinib.
A team of researchers led by Georges Belfort has discovered water wires in an imidazole molecule, which could lead to the development of artificial aquaporin membranes for efficient desalination. The study shows that the imidazole's ring structure enables water molecules to self-assemble into a highly oriented linear chain structure.
Researchers uncovered a new lacewing species with anatomical modifications mimicking coeval liverworts, demonstrating the first record of liverwort mimicry by fossil insects. The larvae's foliate lateral plates and unique morphological features aid their survival and likely enable stealthy hunting or ambush predation.
A Northwestern University study found that online ratings for cosmetic breast augmentation surgeries are highly polarized, with some reviews written by non-patients. The importance of interactions with the doctor's support staff is highlighted as a key factor in patient satisfaction.
Dr. Paul Offit, Director of Vaccine Education Center at Children's Hospital of Philadelphia, receives the 2018 Albert B. Sabin Gold Medal for his groundbreaking work on an oral rotavirus vaccine that has saved thousands of children's lives globally. He is recognized for his tireless advocacy for immunization and leadership in promoting...
The lab will upgrade its unique computed tomography facilities to enable high-resolution, in situ, three-dimensional material characterization with unprecedented three-dimensional imaging quality and efficiency. The research aims to study physics phenomena governing manufacturing irregularities or defects in composite parts.
Chemists at Colorado State University have discovered a polymer with high molecular weight, thermal stability, and mechanical properties comparable to conventional plastics. The new material can be recycled back to its original state under mild lab conditions, paving the way for a circular materials life cycle.
Research by UCI scientists finds that corals in locations with frequent temperature changes are more resilient to bleaching. This discovery provides a better understanding of coral reef health and can inform conservation efforts.
A multi-center study discovered how adenosine to inosine (A-to-I) RNA editing contributes to protein diversity in breast cancer, increasing cancer cell proliferation and invasion. The findings suggest that individualizing therapies for each patient is reliant upon a better understanding of the protein genome.
Researchers from INRS published a study demonstrating the potential effects of neonicotinoids on human health by disrupting hormonal systems. The study found an increase in aromatase expression and changes in its pattern similar to those observed in certain breast cancers.
Researchers studied the teeth of carnivorous dinosaurs and found that different species used varying biting strategies to capture and consume their prey. The study reveals that some dinosaurs, like Dromaeosaurus, were adapted for handling struggling prey or processing bone, while others, like Troodon, preferred softer fare.
A new study by Penn Medicine neurologist Amit Bar-Or presents findings on ocrelizumab's impact on multiple sclerosis patients, including reduced inflammation and lower vaccine response levels. The research also explores the role of ocrelizumab in limiting MS attacks.
A new stereovision system guides surgeons during spinal operations, providing accurate renderings of where implants need to go. The system, developed by Dartmouth engineers and physicians, is expected to save up to 30 minutes in surgery time.
Researchers at Broad Institute of MIT and Harvard have developed a new tool that enables clinicians to quickly diagnose patient samples and track epidemics using CRISPR-based SHERLOCK. The platform can detect viruses directly in bodily fluids, eliminating the need for lab equipment and trained personnel.
A study of nearly 6,000 Americans found that mid-life chronic inflammation may be linked to an increased risk of frailty and overall poorer health decades later. Having high levels of inflammation in middle age was associated with a 39% higher odds of frailty approximately 24 years later.
10% of patients infected with the rising European strain experience abdominal pain, a symptom often overlooked by doctors. The study's findings highlight the need to consider this atypical form of meningococcal disease in medical diagnosis.
A laboratory analysis found that some landscape shapes retain their past forms under turbulent flows, while others erase their initial shapes. The study's results have significant implications for geological dating and understanding the formation of landscapes.
Researchers discovered Zika virus can infect and destroy human CNS tumor cells, reducing tumor mass and increasing survival rates. The virus shows a greater affinity for CNS tumor cells than healthy neural stem cells.
A team of scientists led by Alex Schier has developed a new method to trace the entire history of individual cell differentiation. They discovered that cells can leave their initial path and change their identity, leading to a more flexible developmental program than previously thought.
A new study presents promising results using 3D printing technology to predict and prevent paravalvular leaks in patients undergoing TAVR. The study's findings suggest that personalized valve placement and size can lower the risk of leaks, improving patient outcomes.
The UK EPSRC has funded 11 research projects to address challenges in building trust, privacy and security in the use of personal data and digital technology. These projects focus on areas such as personalised e-books for children's reading, IoT devices in homes, and trusted sharing of personal health data.