A multigene test used in breast cancer treatment helps doctors decide on chemotherapy, improving prognosis and reducing unnecessary treatments. The study found that patients with high-risk tumors had a five-fold increased risk of metastases and lower disease-free survival rates without chemotherapy.
Breast cancer survivors who participated in a lifestyle intervention program lost weight and had higher disease-free survival rates compared to those who received general recommendations. The study found that completion of the program was associated with a 35% higher rate of disease-free survival.
A study by Imperial College London and University of Leicester found that patients taking high-intensity statins and adhering to treatment regimens can avoid 12,000 cardiovascular events. High adherence achieves better long-term cholesterol reductions and outcomes for patients.
A Georgetown University Medical Center study found that nursing homes experience improved quality of care during periods of recession and worsened care when the economy is good. Higher unemployment rates are linked to higher nursing staff levels, leading to better retention and reduced turnover.
Experiments at PPPL demonstrate striking similarities between laboratory findings and satellite observations of magnetic reconnection in space. Researchers found that electron and ion currents flow perpendicular to the magnetic field, converting energy and leading to northern lights, solar flares, and geomagnetic storms.
A new algorithm developed by Yale Ph.D. student TC Chakraborty creates a more comprehensive and consistent estimate of urban heat islands worldwide. The Global Surface UHI Explorer map uses urban agglomerations instead of administrative city boundaries, providing surface UHI intensity estimates for over 10,000 urban clusters.
Recent studies have questioned the conventional dating of indigenous sites in Ontario, Canada, with new evidence pointing to a 50-100 year shift in dates. The findings suggest that early contact between indigenous people and Europeans may have occurred later than previously thought.
The UTA College of Architecture is working to advance water research with a focus on sustainability through its new UNESCO chair and a $1 million STARs grant. The college aims to explore ways to equitably manage the region's water resources, building on existing research efforts.
Fruit flies were first found in southern Africa, where they colonized the area after humans moved in around 10,000 years ago. The flies are attracted to marula fruit, which has been linked to their historical presence among indigenous tribes.
A University of Bonn study suggests that bioplastics may not be as environmentally friendly as thought, as increased production could lead to land use changes and greenhouse gas emissions. The researchers found that even with a tax on conventional plastics, the benefits are temporary and offset by negative economic effects.
Researchers explore how scientific understanding of Zika developed over time and how North American agencies addressed public communication challenges. The special issue provides insights into the dissemination of information via traditional and social media and its effects on public knowledge and risk perception.
A new case study examines the planning processes behind Chicago's 606 Trail and concludes that nonprofit coordination multiplied gentrification risks due to fragmentation. The trail's $95 million project converted an abandoned rail line into a multi-use path, but ignored displacement concerns and accelerated environmental gentrification
A 'friendly' EMP generator has been used to test various electronic devices, including military equipment and civilian products, for their ability to withstand an electromagnetic pulse. Preliminary results show that some devices can be protected with additional shielding.
Bacteria adapt more slowly and less efficiently when exposed to two stress factors, leading to smaller population sizes. This affects the evolution of antibiotic resistance, as bacteria are less able to protect themselves from predators, resulting in a stronger influence on their survival rate.
The National Trends in Disability Employment - Monthly Update (nTIDE) shows modest increases in employment-to-population ratio and labor force participation rate for Americans with disabilities. The data continues the upward trend of economic indicators for people with disabilities, reflecting higher demand for workers.
A team of researchers has discovered a 'blind spot' in atomic force microscopy that can lead to incorrect results due to the use of certain force laws. However, they have also developed a new mathematical method to identify and avoid this issue, safeguarding atomic force measurements from inaccurate results.
Researchers at MIT created variants of a wasp venom peptide that are potent against bacteria while nontoxic to human cells. The peptides were designed by analyzing the structure and function of the original molecule, identifying optimal percentages of hydrophobic amino acids and positively charged amino acids.
A study found that younger breast cancer patients who underwent mastectomy reported lower breast satisfaction and poorer psychosocial and sexual well-being compared to those who had breast-conserving surgery. The researchers also found similar physical function across all groups.
A research team at Lund University successfully reprograms mouse and human skin cells into immune cells called dendritic cells. This breakthrough enables the development of novel dendritic cell-based immunotherapies against cancer. The process is quick, effective, and opens up possibilities for patient-specific treatment.
A randomized controlled trial found that vitamin C supplementation reduced harm to infants' lungs caused by smoking during pregnancy. Infants whose mothers took 500mg of vitamin C in addition to their prenatal vitamin had significantly better lung function at three months of age, according to the study.
A comprehensive review highlights novel approaches to slow or prevent Alzheimer's disease, focusing on the effects of aging on the brain. Combination therapy is deemed necessary for better treatment outcomes, similar to other major diseases.
The study found that over half (55.3%) of the 365 victims had consumed alcohol or drugs shortly before their death, with a high prevalence of cocaine and cannabis use. This correlation suggests a significant link between substance use and violent deaths in São Paulo City.
Children in Alaska may have elevated cancer risk due to insecticides like DDT in the meltwater, especially those who rely on fish as a staple diet. Researchers found that even low levels of organochlorine pollutants can increase cancer risk for youth and adults.
Scientists at HZDR created an iron-rich compound in a semiconductor that became magnetic due to the formation of two-dimensional lamellae. This unusual structure could help understand superconductors and optimize their properties.
A commentary published in The Lancet Public Health highlights the need for governments to commit to reducing traffic deaths and invest in road safety. According to Dr. Adnan Hyder, more than a million people die from traffic crashes worldwide each year, with no decline in death toll since 2009.
Salinization affects biodiversity and water ecosystem functioning directly, but more baseline information is needed to predict its effects. The main causes of salinization in Spain include mining, agriculture, and regime changes in precipitations.
A new study found that consuming a Mediterranean-type diet rich in plants and olive oil significantly reduces the risk of cardiovascular disease among American women. The diet's benefits were attributed to changes in inflammation, glucose metabolism, and insulin resistance.
Developed by HZB teams, the photocathodes exhibit high quantum efficiency and stability, crucial for superconducting electron sources. The new process delivers desired performance, with quantum efficiency remaining high even at low temperatures.
David Cheresh, a renowned cancer researcher, has received a $4.2 million NCI award to investigate how tumors adapt to stress and develop drug resistance. His research aims to find ways to perturb the malignant cell version of wound repair, potentially eliminating highly drug-resistant cancers.
Research reveals a significant gender bias in how we perceive competence in faces, with masculine faces being rated as more competent. The study used a computational model to alter face stimuli and found that participants perceived more competent faces as more confident and masculine.
ETRI's QKD system achieves secure key rate of 142.94 kbps in daylight, demonstrating its potential for secure communication in various applications. The self-developed polarization encoding chip reduces the system size and paves the way for commercialization.
A study of 561 young women with breast cancer found that those who underwent mastectomy scored lower in quality of life measures, including satisfaction with appearance, psychosocial well-being, and sexual well-being. Breast-conserving surgery was associated with better outcomes, regardless of whether one or both breasts were removed.
A new study from Cornell University suggests that graphic warning labels on cigarette ads have a significant anti-smoking effect on children and young adults. The research found that these warnings can cancel out the appeal of smoking as cool and fun, reducing the influence of social cues in advertising.
Researchers from the University of Konstanz have demonstrated that lossless electrical transfer of magnetically encoded information is possible, enabling enhanced storage density and reduced energy consumption in computing centres. This finding paves the way for novel functionalities in future energy-efficient information technologies.
Researchers developed a rapid screening method to evaluate drug responses of leukemia stem cells and blast cells from individual patients. The study revealed unique drug susceptibility patterns, with promising targets identified for patient-specific therapies.
Researchers discovered a mechanism for how ice particles and certain molecules release harmful substances into the atmosphere. The study found that organic molecules attach to ice particle defects, leading to UV radiation-induced radicals that damage the ozone layer.
The new TAILORx trial data reveals racial disparities in breast cancer outcomes, with 83.1% white women alive and cancer-free after nine years, compared to 78.9% black women. The study suggests biological factors contribute to the differences, regardless of treatment type or duration.
A new study by MIT researchers finds that compiling massive, anonymized datasets about people's movement patterns can make it easier to discern users' identities. The study shows how merging different types of location-stamped data can lead to a high matchability success rate, increasing the possibility of deanonymizing real user data.
A new study from the University of Washington and Stanford University reveals that global warming was the primary cause of the Permian mass extinction, which wiped out 80% of oxygen in the oceans. The research predicts that high-latitude species were nearly completely wiped out due to their high oxygen demands.
Researchers have identified a natural flavonoid, 2'-Hydroxyflavanone (2HF), effective in treating Leishmania amazonensis infections. The compound showed no side effects and reduced parasite loads and lesion sizes in infected mice.
A study found that only 53% of UK schools have received staff training on self-harm, highlighting the need for comprehensive training to support students. Despite this, many schools see themselves as a site for prevention and intervention activities, indicating a positive approach to addressing adolescent self-harm.
A phase 2 trial of 70 men with cannabis dependence or use disorder found that an experimental drug reduced cannabis use and withdrawal symptoms compared to placebo. The drug, PF-04457845, works by blocking an enzyme that breaks down a natural endocannabinoid chemical in the brain.
A new Louis Stokes Regional Center of Excellence will help broaden participation of minority students in nanotechnology and STEM fields. The center will provide remote access to nanotechnology instruments, research experience, and professional development for educators.
Researchers at VCU are testing a vaccine that blocks heroin and fentanyl effects in patients with opioid use disorder. The vaccine prompts the immune system to generate anti-opioid antibodies, preventing drug molecules from crossing the blood brain barrier.
Researchers found that Catholic health care facilities often limit common women's health services like contraception and sterilization, and may only offer pills as a contraceptive method. The study highlights the need for further exploration of how institutional restrictions impact patient outcomes.
A new study identifies key molecular features that predict clinical outcomes in neuroblastoma patients. The research suggests a molecular classification scheme to select the best treatment for each patient, with tumors lacking telomere maintenance mechanisms considered low-risk and those with these features deemed higher-risk.
Scientists at Monash University have identified a new immune brake called CD96 that enables tumors to evade the immune system. Blocking this receptor may lead to more effective cancer treatments. The research has significant implications for cancer immunotherapy.
A large clinical trial found that black women with hormone-receptor positive breast cancer had a higher risk of recurrence and death compared to white women, even when treated equally. The study suggests biological differences may contribute to the disparity in outcomes.
A 180-million-year-old ichthyosaur fossil has yielded surprisingly well-preserved soft tissues, including skin that retains some of its original pliability. The study reveals the presence of blubber under the skin, similar to modern whales and sea turtles.
Advanced breast cancer patients with detectable PIK3CA mutations in their blood show improved progression-free survival when treated with alpelisib added to fulvestrant. Liquid biopsy analysis reveals a 45% risk reduction compared to tissue biopsy.
A study by ETH Zurich researchers found that clean air would increase solar radiation nationwide, allowing for a one-tenth increase in electricity production. This could lead to additional electricity generation of 85-158 terawatt hours per year, generating significant revenue for the Chinese electricity industry.
Research suggests that distinct HIV-1 strains differ in their interaction with CCR5 molecules, affecting cell infectability and entry efficacy. The study found that the nature of these receptor interactions regulates viral properties and has potential implications for developing targeted therapies.
Researchers at RIT are developing an advanced visual tracking system using deep learning and artificial intelligence to refine object location and movement. The system has potential applications in autonomous navigation, drones, traffic monitoring, safety, security, disaster response, and human-computer interaction.
A McGill-led research team has developed a computational process to track the transmission histories of rare genetic diseases, tracing CAID back to two European founding families in 17th century Quebec. The researchers hope to extend their search techniques to more common genetically based diseases and identify new genetic variants.
Research suggests that having a regular bedtime and getting enough sleep from early childhood may lead to healthier body weight in adolescence. Children who had age-appropriate bedtimes were found to have optimal sleep patterns and lower BMI compared to those with suboptimal bedtimes.
A study in Central America, Africa, and Asia finds that implementing simple climate-resilient strategies can increase yields, benefit the environment, and increase farmer income. The research proposes site-specific techniques, such as crop rotation and organic fertilization, which have estimated rates of return ranging from 17% to 590%.
Researchers from Aarhus University and the University of Queensland found that newborns with vitamin D deficiency had a 44% increased risk of being diagnosed with schizophrenia as adults. The study suggests that ensuring pregnant women have adequate levels of vitamin D may result in the prevention of some schizophrenia cases.
A study by Oregon State University found that consuming hazelnuts daily for 16 weeks improved magnesium levels and reduced low-density lipoproteins (LDL) in older adults. Urinary levels of a vitamin E breakdown product also increased, indicating an improvement in overall nutritional status.
A UK-wide consortium led by the John Innes Centre aims to enhance surveillance and response to Xylella fastidiosa, a devastating bacterial plant pathogen. The £4.85m BRIGIT programme will improve diagnosis and detection methods, identify potential factors for its spread, and prepare to minimize its impact on the UK.
Researchers used PET scans to track TB drug levels in a rabbit model and human patients, revealing that current treatments may not be effective due to poor penetration of the drug into infected brain lesions. The study aims to optimize treatment by tailoring doses for individual patients based on imaging results.