A large clinical trial found that two commonly used antipsychotic drugs did not affect delirium or survival rates in critically ill ICU patients. The study suggests that antipsychotics may not be an effective treatment for delirium and highlights the need to reexamine current treatment strategies.
Researchers have developed a new method for administering the antibiotic ceftriaxone through rectal delivery, which could save thousands of newborn lives annually. The approach builds upon earlier work and has been shown to be effective in treating critically ill patients with sepsis.
Researchers found a unique microbial signature for esophageal cancer that could help identify at-risk individuals and develop alternative therapeutic strategies. The study suggests that analyzing the oesophageal microbiota may provide innovative diagnostic tools to improve the management of this condition.
A proposed taxonomy categorizes conscience protections based on state or private actors, as well as provider conduct. Bioethicists must shape AI and machine learning to prevent moral pitfalls, including exacerbating human biases and weakening patient confidentiality.
A study found that 85% of US-based humanitarian surgical NGOs follow guideline-based practices when providing care abroad, with a focus on standard operating room timeouts and perioperative antibiotics. The majority also showed interest in developing consensus best practice guidelines for short-term surgical missions.
A study by Drexel University researchers explores the public's willingness to use brain stimulation devices, revealing a divide between personal and moral acceptance. Participants were more likely to support using brain stimulation on others to repair cognitive functions than enhance their own abilities.
A neuroimaging study identifies two brain regions sensitive to visual scenes that respond differently to tasks involving place recognition and navigation. The results suggest a more multifaceted human visual system, with potential applications in computer vision systems and recovery from brain injuries.
Jillian Rose, Hospital for Special Surgery's director of Community Engagement, Diversity and Research, received the ARHP Distinguished Educator Award for her innovative teaching, innovative initiatives, and dedication to promoting health equity in rheumatology care. Her work has been recognized nationally and internationally.
Scientists have discovered that alcohol blocks a potassium channel called KCNK13 in the brain, leading to increased dopamine release and pleasure. This finding presents an exciting new target for developing drugs to treat alcohol use disorder.
A new study suggests that HPV-positive throat cancer patients benefit from chemoradiotherapy, leading to higher overall survival rates compared to cetuximab treatment. Cisplatin chemotherapy and radiotherapy proved more effective in reducing cancer recurrence and improving patient outcomes.
A new multi-national database will help researchers address questions about bipolar disorder throughout the adult lifespan. The database will aggregate data from over 1,000 patients worldwide, enabling scientists to uncover patterns of and predictors for the condition.
SLU scientist Daniela Salvemini is studying chemotherapy-induced cognitive impairment and opioid addiction to develop new treatments. Her research aims to identify novel therapeutic approaches to mitigate chemo-brain and improve quality of life for cancer patients.
A study by NRG Oncology found that short-term androgen-deprivation therapy (ADT) combined with radiotherapy improved overall survival for men with early stage prostate adenocarcinoma for up to 10.4 years. However, the benefits dissipated after 18 years.
A phase III clinical trial found immunotherapy pembrolizumab to be more effective than aggressive chemotherapy as a first-line treatment for advanced head and neck cancer. Patients with high PD-L1 levels saw significant improvements in survival and response rates.
Researchers analyzed over 57,000 publications on swine pathogens from 1966 to 2016, revealing emerging infectious diseases with increased research funding priority. Global networks of swine pathogen research were also mapped, showing regional collaboration patterns and colonial relationships.
Researchers induced a mild brain injury in mice and used neural precursor cells to show recovery of lesions and improved motor functions. The study suggests that these cells may enable the brain's own cells to repair damaged areas.
The HOBOE-2 trial found that zoledronic acid plus letrozole improved disease-free survival in premenopausal women with HR+ early breast cancer, with a 5-year DFS probability of 0.93 compared to 0.85 for tamoxifen. The combination treatment reduced breast cancer recurrence and mortality by nearly half.
A new study finds that 12% of frequent marijuana smokers experienced Cannabis Withdrawal Syndrome, including symptoms like nervousness, hostility, and sleep difficulty. The study also links CWS to psychiatric disorders, mental disability, and a family history of depression.
Researchers developed a mathematical model describing motion of dark matter particles inside the smallest galaxy halos. They observed that over time, dark matter may form spherical droplets of quantum condensate. The study found that Bose-Einstein condensate can form in the centres of small halos, and it may produce Fast Radio Bursts.
A new study published in JAMA Internal Medicine finds that community health workers can significantly improve clinical outcomes among chronically ill patients. By providing hands-on support, coaching, and social services, community health workers reduced hospital stays by 65% and improved patient satisfaction with primary care.
A study from Rice University found that grief can cause inflammation leading to negative health outcomes such as cardiovascular problems and premature mortality. Researchers discovered that widows and widowers with elevated grief symptoms suffered higher levels of bodily inflammation.
Among pediatric patients aged 20 or younger, there was a notable increase in vertical sleeve gastrectomy and a decrease in laparoscopic Roux-en-Y gastric bypass procedures between 2005-2014. The use of adjustable gastric bands also decreased during this time period, reflecting trends seen in adult metabolic bariatric surgery procedures.
A large, long-term study found SBRT to be safe and effective for men with low- and intermediate-risk prostate cancer. The treatment delivered substantially larger doses of radiation per session, reducing the duration of treatment without increasing the risk of severe side effects.
A new study published in the journal Diabetes found that fathers' exercise habits can improve their offspring's glucose metabolism and reduce body weight, even if they were born to parents who consumed a high-fat diet. The research also suggests that small RNA changes in the father's sperm may play a role in transmitting beneficial met...
Median nerve stimulation triggers release of neuropeptide orexin from hypothalamus, leading to reduced inhibitory control in midbrain's pain-control region. This analgesic effect depends on endocannabinoid receptors, not opioid receptors.
Climate change and overexploitation are driving the decline of caterpillar fungus in the Himalayas. Rising winter temperatures and unfavorable conditions are threatening the sustainability of this valuable traditional medicine component.
A new study suggests that people tend to stay in unsatisfying romantic relationships because they consider their partner's needs and wants. The more dependent the partner is on the relationship, the less likely the person is to initiate a breakup. This altruistic component highlights the complexity of relationship decision-making.
A novel technology for profiling protein turnover and degradation has been developed, revealing distinct evidence of a signature pattern in autoimmune disorders. The technique focuses on degraded proteins, providing clues about the state of protein monitoring and potentially leading to better diagnostic techniques.
Experts aim to understand how birds create resilient nests using twigs, leaves, and other materials, with potential applications in building, packaging, self-repairing, and shock-absorption. By studying the collective mechanical interactions of disordered filaments, they hope to develop new technologies inspired by nature.
Researchers have found associations between addiction-related phenotypes and variants in the PTPRD gene, a neuronal cell adhesion molecule. A chemical compound, 7-BIA, has been shown to selectively inhibit phosphatase activity of PTPRD in mice, reducing cocaine self-administration rates.
A new AI tool is being developed to help doctors diagnose and treat acute respiratory distress syndrome (ARDS), a deadly lung failure that affects approximately 200,000 people in the US. The tool will screen patients throughout Montefiore Health System and provide guidance on best practices for treating ARDS.
The Laser Interferometer Space Antenna (LISA) will enable astrophysicists to study gravitational waves emitted by black holes, which could unveil secrets about dark matter. Simulations suggest a connection between black hole merger rates and dark matter properties.
The SPPORT trial found that adding pelvic lymph node treatment and short-term hormone therapy to standard treatment extends time before cancer spreads. This combination therapy resulted in higher freedom-from-progression rates and lower distant metastasis rates compared to standard treatments alone.
Researchers found that children obese at 5 years old had a 75% likelihood of remaining obese by age 12 and almost 20 times the risk of developing Slipped Capital Femoral Epiphysis (SCFE). Early recognition and treatment are crucial to minimize severity, as SCFE causes lifelong disability.
A new study predicts that gravitational wave readings from neutron star collisions can accurately measure the Hubble constant, improving current disputed results. With 25 readings, accuracy will reach 3%, narrowing to 1% with 200 readings.
Researchers at Max Planck Institute for Chemistry found that isoprene levels in cinema air correlate with film age ratings. The study measured over 13,000 audience members during 135 screenings of eleven different movies, providing a reliable indicator for deciding how movies should be classified.
Researchers at the University of California, Davis found that a brain wave device enhanced both theta wave activity and memory performance in volunteers. The study suggested that entrainment devices may play a role in coordinating brain regions by synchronizing neural activity.
Researchers discovered brain regions deactivated during successful reading recall, suggesting a mechanism for filtering out irrelevant information and focusing on memory commitment. The findings provide new insight into natural reading processes and the neural basis of successful text encoding.
A phase 3 SOLO-1 trial found that olaparib maintenance therapy significantly improved progression-free survival (PFS) in newly diagnosed patients with advanced ovarian cancer and a BRCA1 or 2 mutation. The median PFS for those who received olaparib was approximately three years longer than the placebo group.
Research by University of Sydney reveals a link between chocolate Labrador coat color and reduced longevity, as well as higher rates of ear infections and joint conditions. The study also found that 8.8% of UK Labradors are overweight or obese.
A randomized study shows erlotinib improves progression-free survival and tumor response rate compared to gemcitabine plus cisplatin in stage IIIA-N2 EGFR-mutated NSCLC. Median progression-free survival was significantly longer with erlotinib at 21·5 months versus 11.9 months with chemotherapy.
Researchers found a link between higher levels of interleukin-10 (IL-10) and lower disease-free survival rates after radiotherapy. Elevated CRP levels, a marker of inflammation, were not associated with DFS.
A randomized, placebo-controlled study has shown that cannabis oil can produce clinical remission in up to 65% of individuals with moderately severe Crohn's disease after 8 weeks of treatment. However, the improvement does not appear to result from a dampening down of the underlying inflammatory process.
Patient-reported outcomes from NRG-RTOG 0232 show that brachytherapy alone is the superior treatment for men with intermediate risk prostate cancer, with less toxicities. The study found significant differences in clinician and patient-reported late toxicity profiles between arms.
A large comparison study found that radiotherapy to the prostate improved failure-free survival but not overall survival in men with newly diagnosed metastatic prostate cancer and a low burden of disease. The treatment was well-tolerated, with only modest side effects.
A recent study published in Canine Genetics and Epidemiology found that Labrador retrievers are prone to several health issues, including obesity and ear infections. The study analyzed data on over 33,000 Labrador retrievers and revealed that chocolate-colored Labradors are more likely to develop skin and ear problems.
The combination of avelumab and axitinib improved progression-free survival (PFS) by 6.6 months in previously untreated patients with advanced renal cell carcinoma, with confirmed objective response rates of 55.2% and 25.5%. The study's findings support the potential of this new treatment approach for patients with advanced RCC.
Researchers have developed memristors that mimic the brain's ability to process information efficiently and adapt to changing conditions. The new devices, made from niobium-doped strontium titanate, can 'forget' and retain memories, making them suitable for future electronic brains.
The 11th World Stroke Congress highlights the high impact of stroke in low- and middle-income countries, with over 80% of global stroke burden concentrated in these regions. Experts discuss prevention and treatment strategies to reduce premature mortality from stroke by one-third by 2030.
A study suggests that heart patients should interrupt sedentary time every 20 minutes with a 7 minute bout of light physical activity to expend 770 kcal, associated with a lower risk of premature death. Regular physical activity is key to achieving a healthy life.
Combining a targeted drug with hormone therapy substantially extends survival for women with advanced breast cancer. The combination treatment lived seven months longer than hormone treatment alone, with benefits strongest in women who had previously responded to hormone therapy.
A combination of immunotherapy and chemotherapy significantly extends survival by up to ten months in patients with triple-negative breast cancer. The treatment reduces the risk of death or cancer progression by up to 40 per cent, offering new hope for young women affected by this aggressive form of breast cancer.
Researchers have assembled the largest sets of African genomic data, creating a resource to study genetic structure, disease, and protein function. They identified 10 new associations specific to African populations, including links between genetic variants and diseases such as alpha thalassemia and diabetes.
Researchers created complex origami structures with unprecedented strength, light weight, and expandability using Digital Light Processing (DLP) 3D printing. The innovative approach enables folding and refolding of the structures without breaking, paving the way for numerous potential applications.
A Phase III clinical trial shows that combining immunotherapy with chemotherapy improves progression-free and overall survival for patients with triple-negative breast cancer. The study's results establish a new standard of care in PD-L1+ patients and provide hope for those diagnosed with this aggressive form of breast cancer.
Researchers developed a polygenic risk score for lifespan based on weighted contributions from relevant genetic variants, predicting which participants were likely to live longest. They also found associations between genetic variants and Alzheimer's disease, heart disease, and smoking-related conditions with overall lifespan.
A large study found that drugs approved for women's breast cancer are also effective and well-tolerated in men. Men with metastatic breast cancer received similar treatments to women, including hormonal therapy and chemotherapy, with similar outcomes.
Atezolizumab, an antibody targeting PD-L1, improved survival in metastatic triple negative breast cancer patients by 20%, particularly those with PD-L1 positive tumors. The combination therapy also reduced disease worsening and death risk by 38% in PD-L1 positive subgroup
A phase 3 clinical trial found that ixekizumab significantly improves AS symptoms, disease activity and quality of life after 16 weeks. The treatment was well-tolerated despite more frequent adverse events compared to placebo.
The PALOMA-3 study found that the CDK4/6 inhibitor palbociclib significantly improves progression-free survival in patients with HR+/HER2- advanced breast cancer. In a new analysis, palbociclib plus fulvestrant was shown to improve overall survival by 6.9 months compared to placebo plus fulvestrant.