A study published in CANCER found that weight loss in postmenopausal women is associated with a 12% lower risk of invasive breast cancer. Women who lost 5% of their body weight had a lower risk, while those who gained weight had an increased incidence of triple negative breast cancer.
Researchers at University of Pennsylvania have developed a new method to sequence epigenetic marks on DNA, allowing for more precise detection of disease earlier and with increased precision. The method uses APOBEC DNA deaminases to differentiate between two common epigenetic marks, methylation and hydroxmethylation.
Researchers confirm collision of white dwarf and brown dwarf stars using ALMA observations. The debris from the explosion reveals the presence of lithium and unusual element isotopes.
Researchers at New Jersey Institute of Technology have identified a new bacterium capable of degrading both 1,4-Dioxane and 1,1-DCE simultaneously. The microbe, Azoarcus sp. DD4 (DD4), has shown impressive efficiency in reducing levels of these toxic chemicals in contaminated groundwater samples.
Researchers have discovered that polymer nanoparticles exhibit distinct characteristics compared to larger particles of the same material, including surface mobility and elastic modulus. The findings could improve the performance of materials used in various applications, such as filter membranes and sound wave propagation.
A study finds that phosphorus accumulation in watersheds can reach a catastrophic threshold, accelerating runoff and harming aquatic ecosystems. The researchers estimate that some watersheds could reach this point in less than a decade due to high fertilizer use rates.
Nonmigratory Atlantic salmon can extract positional information from Earth's magnetic field, orienting themselves appropriately in response to different magnetic conditions. This skill may enable salmon escaping from aquaculture to better navigate and invade habitats, challenging previous assumptions about their navigational abilities
A groundbreaking study found community programs and policies significantly associated with lower BMI in children, suggesting a comprehensive approach is key. Implementing multiple, strong, and long-lasting initiatives targeting diverse behaviors can lead to healthier weight outcomes for kids.
Caltech researchers develop two illusions to demonstrate postdiction, a phenomenon where later stimuli retroactively affect earlier perceptions. The Illusory Rabbit and Invisible Rabbit illusions show how sound can influence vision, highlighting dynamic neural processing.
Researchers found that Dutch delta plain's unique history can inform management of modern deltas, which face similar challenges like land subsidence and sea level rise. Human activities such as reclamation and agricultural expansion triggered the formation of new rivers along courses that natural branches would not have taken.
Scientists have discovered that a specific region of the brain, known as the ventrolateral preoptic nucleus (VLPO), plays a crucial role in regulating sleep and body temperature. Activating these cells causes a profound drive to sleep, while excessive stimulation can lead to prolonged sleep and a drop in body temperature.
A new study shows that land-locked Atlantic salmon use the Earth's magnetic field as a navigational tool, similar to Pacific salmon. The ability is retained even after several generations of fish in a land-locked lake. This raises concerns about the impact on native salmon and ecosystems if these fish escape aquaculture pens.
The study reveals that the islanders used coastal groundwater discharge as their main source of drinkable water, making it possible for humans to collect freshwater directly at the coast. This finding is crucial in understanding how the island's large population was sustained.
Researchers at Rutgers University have discovered a new delivery system that can effectively combat bacterial infections. The nanostructured silica particles contain payloads of an antimicrobial agent and were found to be more effective at killing bacteria than the agent alone.
Employment outcomes for people with disabilities vary significantly across states and counties, influenced by economic conditions, physical environment, and policy variables. Research finds that environmental factors are a strong predictor of employment rates, highlighting the importance of considering local context in policy development.
Researchers at NC State have developed self-sterilizing antimicrobial materials that can inactivate bacteria and viruses using only visible-wavelength light. The new approach opens the door to a range of new products aimed at reducing the transmission of drug-resistant pathogens.
The Universidad Carlos III de Madrid has launched the Laboratory of Discrimination and Inequality (D-Lab), aiming to advance research on discrimination and social inequality. The lab is currently working on projects such as GEMM, analyzing ethnic discrimination in employment across five European countries.
Patients with AFib and a history of cancer are more likely to experience suboptimal antithrombotic care, leading to increased risk of stroke. Cardiology providers play a crucial role in improving outcomes for these patients, according to a study published in the Journal of the American College of Cardiology.
Researchers found that wasp and bee stingers are softer at the tip than at the base, allowing for easier penetration. The study also showed that the stingers are about seven times more elastic at the tip than at the base, enabling them to penetrate deep while maintaining their structure.
A new technology called EFIRM has been developed to detect two cancer-linked mutations in blood or saliva samples from patients with early-stage lung cancer. The platform shows promise in identifying stages 1 and 2 NSCLC when surgical resection is still possible, offering a potential cure.
Researchers at the Buck Institute have developed a new method to pinpoint genetic differences between closely related species, which could lead to breakthroughs in understanding human longevity, disease resistance, and regenerative abilities. The technique was tested using an ancient divergence in yeast and has wide applicability to pl...
Researchers studying vampire bats and Morbillivirus aim to understand how viruses persist inside the body and trigger new infections. The project aims to gain fundamental insights into RNA virus persistence and potentially shed light on diseases like SSPE.
The study found that mountain snowpack is vulnerable to climate warming, with a 20-40% decrease in above-average snow water equivalent for 1-2°C temperature increases. Regional variations were observed, with northern regions more susceptible than southern ones, affecting water resource management and wildfire activity.
Researchers found that immunotherapy is effective in treating metastatic melanoma in individuals with CDKN2A mutations, with nearly two-thirds of patients responding to treatment. The study suggests that tumours with CDKN2A mutations have a larger number of mutations, making them easier to recognise by the immune system.
Researchers estimate bottom trawl footprints on continental shelves and slopes up to 1,000m in depth. Sustainable fisheries management may provide collateral environmental benefits by reducing trawling footprints in regions meeting international benchmarks for sustainable fishing rates.
Researchers from Uppsala University have identified previously unknown retroviral insertions in European rabbits, shedding light on how ERVs spread in host populations. The study reveals substantial variation across ERV insertions in different rabbit populations, providing a genomic record of retrovirus-host associations.
A study analyzing over 937,000 single embryo transfer cycles found that the proportion of multiple pregnancies is 1.6% and 1.36% result from true zygotic splitting. Factors increasing the risk include frozen-thawed embryos, longer blastocyst maturation, and assisted hatching.
Researchers at Imperial College London have created a genetically engineered version of a cell called an invariant natural killer T-cell (iNKT) that shows potential as a new treatment for cancer. The CAR19-iNKT eliminated all cancer cells in 60% of mice and had 90% long-term survival rates.
A study published in Nature identified a tumor cell population responsible for resistance to therapy and tumor relapse in basal cell carcinoma. The researchers found that vismodegib promotes the differentiation of tumor cells, leading to their elimination, but also reveals a dormant population of tumor cells with active Wnt signaling.
Researchers, led by Dr. Nikolaus Wenger, are developing neural prostheses for brain-computer interfaces to treat neurological disorders. The goal is to understand how the brain processes information and develop a prosthesis that can transmit signals back to the nervous system.
Consuming too much vitamin A may decrease bone thickness and increase fracture risk in humans. A recent study found that mice exposed to lower doses of vitamin A equivalent to 4.5-13 times the recommended daily allowance showed significant weakening of bones over a 10-week period.
Researchers create semiconducting films from materials like gallium arsenide, lithium fluoride, and silicon, with potential for low-cost, high-performance devices. The technique uses remote epitaxy and graphene, allowing for the production of flexible electronics that outperform traditional silicon-based devices.
Researchers at ETH Zurich successfully heal genetic disease phenylketonuria in mice using a modified CRISPR/Cas9 system. The technique achieved a high correction rate of up to 60% and restored normal levels of phenylalanine, eliminating the disorder's symptoms.
Scientists at Northwestern University have created a bioelectronic medicine that uses electrical stimulation to accelerate nerve regeneration and improve muscle strength in rats. The device, made of biodegradable materials, is powered wirelessly and operates for up to two weeks before naturally absorbing into the body.
Researchers found no clear evidence that statins benefit patients with non-Cardiovascular Disease (CVD) conditions, except for preventing deaths from kidney disease. Statins may also slow cancer progression, but further investigation is needed.
A phase II study led by the University of Texas MD Anderson Cancer Center found that neoadjuvant combination checkpoint blockade produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery. However, the trial was closed early due to high incidence of side effects.
Researchers at USC have created a new map of the mouse hippocampus, revealing its internal circuitry and nerve connections in vivid detail. The study aims to provide a resource for scientists to better understand the brain's memory bank and develop strategies to target neurons for treatment.
Research reveals 73% of patients with drug-associated infective endocarditis are uninsured or on Medicaid, adding significant burden on hospitals and government budgets. The median hospital charge for valve replacement surgery exceeds $251,000, with over 280 surgeries performed annually in North Carolina.
A new drug test developed at the University of East Anglia can detect four classes of drugs in traces of sweat found in a fingerprint. The Intelligent Fingerprinting Drug Screening System enables rapid detection of amphetamines, cannabis, cocaine, and opiates from a single fingerprint sample.
A new study suggests targeting collagen XIII could suppress breast cancer metastasis by enhancing anoikis resistance in cancer cells. Researchers found that collagen XIII expression is significantly higher in cancerous human breast tissue and necessary for metastasis in mouse models.
A study by North Carolina State University found that the ACM code of ethics has no impact on software developers' decision-making. Researchers presented 11 ethical scenarios to 168 participants, with and without prior exposure to the code of ethics, and found no significant difference in responses.
Researchers discovered that mutations in the ARID1A gene lead to a molecular switch in the SWI/SNF protein complex, causing an increase in BCL2 expression and promoting tumor cell survival. Inhibiting BCL2 using a small molecule inhibitor kills ovarian cancer cells resistant to EZH2 inhibition.
Researchers used the n_TOF facility to explore a neutron channel that could increase the destruction rate of Be-7 and resolve the Cosmological Lithium Problem. However, the results indicate that neutron channels alone are not enough to resolve the issue, leaving scientists with additional challenges to address.
Researchers found that patients taking full-dose allopurinol for gout flares had a lower risk of developing Stage 3 Chronic Kidney Disease (CKD) compared to non-users. The use of allopurinol may be beneficial in reducing kidney disease risk, contrary to previous concerns.
Researchers at UCLA will use a new liquid biopsy tool to test individuals at risk of lung cancer, with the goal of detecting the disease earlier. The technology aims to differentiate between cancerous and benign lung lesions, reducing unnecessary procedures and improving patient outcomes.
Researchers at University of Basel developed new approach to analyze microbial molecular fossils in lake sediments, providing reliable temperature estimates. The study's findings can be applied globally, offering improved predictions for future climate conditions.
Researchers discovered that neural encoding of sensory information leading to belief updates is negatively related to dopamine receptor availability. The study also found a link between dopamine and the ability to flexibly update beliefs, with paranoid ideation being negatively related to sensitivity to meaningful sensory information.
A study published in Annual Review of Environment and Resources projects that global sea levels will likely rise 6-10 inches from 2000 to 2050, but more sensitive projections beyond 2050 depend on greenhouse gas emissions and projection methods. Rising seas pose a significant threat to coastal populations and ecosystems worldwide.
Scientists have performed prenatal gene editing in laboratory animals to prevent a lethal metabolic disorder, offering the potential to treat human congenital diseases before birth. Using CRISPR-Cas9 and base editor 3, researchers reduced cholesterol levels and improved liver function in mice with genetic mutations.
The Center for Human Genetics is conducting research to better understand the genetic causes of rare diseases using a combination of genome-wide association analysis and gene-editing techniques. The team has identified novel transcribed regions that play a crucial role in regulating complex traits.
Research suggests statins may benefit people with certain non-heart diseases, such as kidney disease and cancer progression, but the evidence is inconclusive. The study found a modest link between statin use and diabetes, highlighting the importance of lifestyle advice for patients at risk.
Less-educated African American women who experience high levels of racial discrimination are more likely to develop chronic diseases. Higher education may buffer against some negative health effects of bias, according to the study.
Researchers developed a low-power chip that integrates lasers and frequency combs for the first time, enabling ultrafast processes in physics, biology and chemistry. The device can be powered by an AAA battery, opening up new possibilities for portable devices.
A recent study published in The Journal of the American Osteopathic Association found that long-term oxygen therapy does not decrease hospitalization risk or increase life expectancy for many patients with mild to moderate COPD. However, it may lower quality of life due to its significant costs and practical challenges.
Researchers at Kansas State University's Biosecurity Research Institute are studying African swine fever to prevent a potential US outbreak. The virus has already spread throughout Asia and Eastern Europe, threatening the global swine industry.
A recent study explores the feasibility of measuring atmospheric pollutants in China using geostationatory satellites. The research recommends suitable sensor parameters for improved retrieval sensitivity and reduced errors, paving the way for more accurate monitoring and control of air pollution.
Researchers have developed a single-cell genomics approach to explore unknown fungal diversity, revealing essential metabolism genes and insights into phylogenetic position. The study successfully reconstructed near-complete fungal genomes from environmental samples, shedding light on the cryptic biology of unculturable species.
Researchers used hyperspectral imaging to analyze a bronze statue by Auguste Rodin, detecting corrosion products brochantite and antlerite. The technique revealed non-uniform distribution of the compounds, which could be missed with traditional sampling methods, providing valuable information for preservation.
Scientists at Sechenov University developed an eco-friendly way to obtain highly active catalysts using supercritical CO2. The new method produced metal-polymeric catalysts with high activity in hydrogenation reactions, offering a safer and cheaper alternative to traditional organic solvents.
Studies using 64 and 28 participants revealed that recalling a target memory enhances retention of both the target and a linked object, with neural activity reinstated in parietal lobe regions. This suggests that retrieval may be an efficient method for memory enhancement.