A new study finds that a combination of chemotherapy drugs performs better than BCG in preventing high-grade cancer recurrence in patients with non-muscle invasive bladder cancer. This alternative treatment has shown excellent safety and efficacy outcomes, providing a viable option for patients facing a shortage of standard care treatm...
Researchers at Johns Hopkins University are developing 'organoid intelligence' using human brain cells, which could exponentially expand computing capabilities and solve energy consumption issues. The technology has the potential to revolutionize drug testing research for neurodevelopmental disorders and neurodegeneration.
Excessive vitellogenin accumulation impairs lysosomal function in germline tissues, leading to reproductive arrest and oocyte quality maintenance. Improvement of lysosomal function is proposed as a potential approach for mid-life intervention in maintaining reproductive health.
Estuaries along the Atlantic coast and eastern Gulf of Mexico are expected to experience significant increases in nutrient loading, posing risks for harmful algal blooms and ecosystem health. The study identified regions with high adaptive capacity as having more resources to mitigate these effects.
A study analyzing centuries-old whaling records reveals Southern right whales are adjusting their feeding grounds in response to climate change. The whales increased use of mid-latitude foraging grounds and slightly shifted towards high latitude areas, affecting their prey availability.
Researchers found strong seasonality in blue whales' foraging and breeding behavior, with changes in vocalizations based on environmental conditions like marine heatwaves. The study's findings can inform conservation management of this endangered blue whale population.
A tiny worm called C. elegans is enabling scientists to explore the emerging theory that Parkinson’s disease starts in the gut, where a sticky protein causes neurons to die. The worms have a digestive tract and neurotransmitters similar to humans, making them a great model for studying cognitive problems associated with Parkinson's.
Scientists discovered a Pink-throated Brilliant hummingbird with gold throat feathers, which is actually a hybrid of two pink-throated species. The hybrid's unique coloration is explained by the complex interaction of genetic and structural factors that determine feather colors.
Researchers catalogued fake interaction resale panels offering customized services, including buying likes, views, followers, and online visits on various platforms.
Researchers found that bacteria's cooperative behavior helps in the short term but fails to protect them from predators. However, individual defense through filament formation proves successful and stabilizes bacterial population densities.
A team of BU School of Public Health researchers will study the cumulative impacts of chemical hazards and climate change on 21 communities surrounding the Mystic River Watershed. They aim to identify solutions that protect vulnerable populations from both chemical and climate stressors.
A patient with Parkinson's disease has received a pioneering stem cell-based transplant at Skåne University Hospital in Sweden. The procedure aims to replace lost dopamine nerve cells and is part of a clinical trial testing the safety and efficacy of this innovative treatment, which could potentially help millions of people worldwide.
Research shows that parental social support and psychological control significantly impact LGBTQ youth's depressive symptoms. High psychological control, however, was linked with more depressive symptoms in those whose parents did not know their identities.
Research reveals that Mahogany trees shape the right-forewing of the Mahogany shoot borer, a forest insect-pest. The study found that the wing form differs between males and females, with larger wings on Cedro host plants.
A new dietary approach has been identified to treat eosinophilic esophagitis by eliminating only dairy products, showing similar effectiveness to the standard six-food elimination diet. This breakthrough study led by CU School of Medicine researchers offers a more patient-friendly treatment option with fewer drawbacks.
Researchers developed a horse-specific compression device that accelerates lymphatic flow, providing potential relief from painful swollen limbs. In a pilot study, six healthy thoroughbreds showed significantly accelerated lymphatic flow compared to untreated horses.
Bielefeld University researchers developed an AI method using Capsule Networks to analyze genotype profiles of 3,000 ALS patients, achieving 87% accuracy in predicting whether or not people will develop ALS. The study reveals over 900 genes that play a role in identifying the disease.
Researchers found that 11 minutes of moderate-intensity physical activity per day, equivalent to a brisk walk, lowers the risk of diseases like heart disease and stroke. This amounts to a 23% lower risk of early death, with benefits also seen in reduced cardiovascular disease and cancer risks.
Scientists at St. Jude Children's Research Hospital demonstrate a framework to develop solutions to evade detoxification networks in drug development, potentially reducing side effects. By altering the structure of a small molecule, they found a way to stretch out binding regions, making it energetically unfavorable for drugs to bind a...
Researchers at Karolinska Institutet have developed a new approach to treating inflammatory diseases by analyzing the activity of genes in individual cells. This digital twin technology could lead to personalized drug therapies for patients with conditions like rheumatoid arthritis, Crohn's disease, and ulcerative colitis.
A new Australian study found that assistance dogs used in conjunction with traditional therapies provide the most effective treatment outcomes for defence veterans' mental health. Almost 90% of veterans reported improvements in post-traumatic stress, depression, and anxiety after being matched with an assistance dog.
Researchers at Flinders University discovered a previously unknown whale behavior, which may have been described in ancient Norse manuscripts. The
Researchers discovered that telomere shortening is associated with early subjective depressive symptoms and cognitive complaints among healthy elderly individuals. The study also found a link between telomere shortening and increased interleukin-6 levels.
A study published in npj Vaccines found that clear communication strategies, such as emphasizing self-interest and common ground, can increase vaccination solidarity among citizens. The researchers recommend a crisis communication approach that highlights the risks of vaccine nationalism and promotes long-term profit orientation.
Researchers propose a novel approach to analyzing microplastic particles, highlighting the importance of particle size and shape in determining environmental impact. Studies show that even samples with similar numbers of particles can have varying levels of plastic pollution based on mass, volume, and specific surface area.
Researchers have developed high-performance, low-cost electrocatalysts through defect engineering to improve metal-based battery efficiency. The review highlights strategies for introducing defects into electrode materials and characterization technologies, as well as design principles for optimizing electrochemical performance.
MIT engineers develop a new purification method using bioconjugate-functionalized nanoparticles to rapidly crystallize proteins, reducing the cost of manufacturing protein drugs. The approach has shown promising results in isolating lysozyme and insulin, with faster crystallization times and increased nucleation rates.
A new study by Dartmouth College researchers finds that sanctions on wealth managers would be more effective than asset seizure in crippling Russia's oligarchs. The research uses network science to map the connections between wealthy individuals and their financial experts, revealing a vulnerable network that can be disrupted with targ...
The study found that pavement skid resistance is crucial in reducing bicycle and electric scooter crashes. Pavements with higher skid resistance, such as asphalt and concrete, are recommended for bike lanes to minimize the risk of falls and collisions.
Growing up in less safe environments can lead to physical and mental health limitations in adulthood. Parents who show they care about their kids' lives can positively impact their health.
A new study from Tulane University compared popular diets on nutritional quality and environmental impact, finding that keto and paleo diets scored among the lowest on nutrition quality and had the highest carbon emissions. Vegan diets, on the other hand, generated significantly less carbon dioxide per calorie consumed.
Researchers at the University of Michigan developed a new control algorithm for ankle exoskeletons that can handle different speeds and changes in gait. The algorithm directly measures muscle physiology, providing more accurate measurements than current methods.
Scientists from Chinese Academy of Sciences have revealed the predictable and unpredictable components of the anomalous WPSH in July 2021. The study suggests that positive precipitation anomalies over the tropical western Pacific driven by La Niña contributed to the northward shift, while atmospheric internal intraseasonal oscillations...
Scientists discovered that 12 strains of cyanobacteria can passively collect rare earth elements from wastewater through a process called biosorption. This process has great potential for the circular recovery and reuse of rare earth metals in industries such as mining, electronics, and chemicals.
A new study found that an ultrasound device consistently reduced daytime ambulatory blood pressure by an average of 8.5 points among middle-aged patients with hypertension. The device targets overactive nerves in the kidneys, disrupting signals that lead to high blood pressure.
A Mass General team has identified a single mutation in a non-coding gene, MIR145-5p, as the source of multisystemic smooth muscle dysfunction syndrome, which had gone undiagnosed in a child for years. The discovery enabled physicians to initiate treatment and lessen the risk of future strokes.
A study of over 93,000 people across 93 countries found that men and women spend an average of four hours a day on beauty-enhancing behaviors. Social media usage is the strongest predictor of attractiveness-enhancing behaviors, with active users investing more time in improving their appearance.
The BIAL Award in Biomedicine is a prestigious international award that recognises outstanding biomedical research. The €300,000 prize is given to researchers whose work has shown exceptional quality and scientific relevance, published within the last ten years.
A new study found that a plant-based low-carbohydrate diet is associated with lower all-cause mortality among people with type 2 diabetes. The study, published in Diabetes Care, analyzed data from over 7,000 participants and found that such diets reduced mortality by 24%.
The CALYPSO study assesses the efficacy of combined MET and PD-L1 inhibition in patients with MET-driven metastatic papillary renal cancer. Response rates were 29% for all patients and 53% for those with MET-driven tumors, with improved progression-free survival observed in MET-driven status.
KISTI's automated weak signal detection technology identifies 439 new weak signals in 24 fields of science and technology, up from 391 last year. The report explores weak signal dynamics, tracking changes and trends between signals.
A new study from Wake Forest University School of Medicine found a strong association between lifetime experiences of discrimination and the incidence of dementia. Researchers analyzed data from over 6,500 participants and discovered that individuals who reported experiencing more than two domains of discrimination had a greater risk o...
Researchers create lab-grown brain organoids as biological hardware to drive computing forward. These three-dimensional cultures can process information faster and more efficiently than current silicon computers.
Recent planetary missions have revealed significant advances in our understanding of Mercury's metal composition and magnetic field, as well as Venus' dense atmosphere and geological activity. On Mars, the InSight mission has detected marsquakes, suggesting a similar internal structure to Earth.
Researchers from Cornell University recommend that planners in suburban and rural communities focus on promoting recreational programs, expanding transportation options, and creating safer environments to help an aging population get more exercise. The study found that demographic factors, such as minority populations and lower incomes...
A new study by Harvard Medical School suggests that face blindness, a condition where individuals struggle to recognize faces, may be more common than previously thought. The research estimates that as many as one in 33 people (3.08%) meet the criteria for face blindness, affecting over 10 million Americans.
A recent study from the University of South Australia found that teenagers with a 'late sleep chronotype' who use technology before bed on weekends are at greater risk of disturbed sleep. This can lead to a serious sleep deficit, negatively impacting their daily tasks and wellbeing.
Researchers analyzed 183 million buildings in 6,000 African cities and found that a city's shape affects its energy demand. Double the population means triple the energy costs due to increased commuting distances and pollution.
Research by the University of the Basque Country found that gluten-free products often lack essential nutrients like fibre and protein. Gluten-free pasta, for example, is now made from millet instead of rice flour, improving nutrition.
University of Southampton researchers propose a new method for diagnosing primary ciliary dyskinesia (PCD) in young children using nasal nitric oxide measurement while they breathe normally. This approach aims to improve early diagnosis and treatment, reducing the need for invasive procedures and enhancing patient outcomes.
Researchers found that conservatives tend to view boundaries as restrictions, whereas liberals see them as guidelines. The study also showed that emphasizing the structural aspect of boundaries can make them more appealing to conservatives.
Researchers at TU Wien have detected clear indications of chaos in chemical reactions on nanometer-scale rhodium crystals, a phenomenon previously unseen in atomic scale systems. The coupling behavior can be controlled by changing the hydrogen concentration, leading to a transition from ordered to chaotic behavior.
A new UBC study reveals midwives provide safe primary care for all medical risk levels, with comparable or improved birth outcomes. Midwives also assist with lower caesarean delivery rates and collaborate with specialists.
Promising RSV vaccines are nearing FDA approval, thanks to a 2013 discovery that enabled the development of vaccines leveraging insights from structural biology. The event features the scientists behind this breakthrough and their perspective on this milestone.
A recent study synthesizes climate trends across the Western US during the Holocene Era, revealing that the hallmarks of California's climate began around 4,000 years ago. The study also sheds light on human-caused climate change and its impact on regional resilience.
A new nanomedicine platform targets brain lipid metabolism to reduce food intake and body weight in mice, offering a promising approach for managing metabolic diseases like obesity. The study demonstrates the effectiveness of this novel treatment, which could potentially provide an innovative solution for controlling energy balance.
A global study of scientific migration reveals female researchers originate from and move to fewer countries, migrating shorter distances than their male counterparts. Gender inequality among mobile scientists varies across countries and over time.
A new study by Amazon uses robotics and operations research to enable humans and robots to work together effectively, reducing distance traveled by robots by 62% and resulting in $500 million in annual savings. The algorithm has also reduced storage footprint by 29%, leading to more efficient use of space and a productive human workforce.
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
Researchers from Florida State University used high-performance computing to simulate the Earth's early history, finding that an ancient magma ocean solidified in under 2 million years. This discovery helps explain chemical diversity in the lower mantle and layering within the Earth.