Researchers discovered that a massive anomaly deep within the Earth's interior may be a remnant of the collision that formed the Moon 4.5 billion years ago. The early Earth exhibited mantle stratification, with different compositions and states in the upper and lower mantle.
A meta-analysis of five clinical trials found that adding docetaxel to standard-of-care treatment reduced prostate cancer-specific mortality by 70% and improved overall survival to 80%. The study focused on high-grade prostate cancer patients with low PSA levels, who previously had limited effective treatment options.
Researchers from China University of Geosciences have clarified the extent of Greater India, a single plate of 2,000 to 3,000 km, before it subducted under Asia. This finding resolves questions surrounding the age of the collision and the emergence of geological structures in the region.
A recent simulation study suggests that giant dinosaur carcasses could have been a key food source for Jurassic predators like Allosaurus. The researchers found that scavenging large carrion was more profitable than hunting, indicating that carnivores in such ecosystems might have evolved specialized traits to exploit these resources.
Researchers found that adolescence is characterized by a universal trade-off in energy demands, which leads to reduced physical activity. Energy boosts are needed for growth and sexual maturity, affecting adolescents more significantly than adults.
Researchers used genetic and molecular tools to create a 3D atlas of gene expression in starfish, revealing that the "head" is distributed across each arm and center. The study provides insight into the evolution of echinoderms, including sea stars, which have a unique body plan compared to humans.
Research at the University of Gothenburg found that even low-active IBD patients have a higher risk of serious infections due to microscopic intestinal inflammation. Achieving a fully healed intestinal mucosa may reduce this risk, contributing to lower morbidity and mortality in IBD patients.
A new study found that high-peace countries are characterized by an increased prevalence of words related to optimism for the future and fun, while low-peace countries feature more references to control and fear. The research used a machine learning model to identify these linguistic patterns in media articles from 18 countries.
Dr. Olugbenga Ogedegbe has been recognized for his pioneering research on health disparities, chronic diseases, and cardiovascular risk reduction, particularly among Black adults in the US. His work aims to reduce hypertension control and racial inequities in cardiovascular disease outcomes.
Researchers found that FAAH inhibition reduced breast cancer growth in immunodeficient mice and induced apoptosis of breast cancer cells. The combination of FAAH inhibitors and endocannabinoids was the most effective treatment approach.
A successful approach that eliminated Delaware's racial disparities in colorectal cancer can now be applied to breast cancer. The 'village' model focuses on building community partnerships and increasing access to care to reduce disparities.
A recent study published in Nutrients found that daily strawberry consumption can improve cognitive performance and reduce depressive symptoms in middle-aged adults. The research, led by Professor Robert Krikorian, suggests that strawberries contain antioxidants and micronutrients that may help mitigate the risk of dementia.
A new study reveals that women with atrial fibrillation (AF) have comparable outcomes to men when undergoing pulsed field ablation (PFA), a safer and more precise procedure. The results show improved AF recurrence rates in women after PFA, making them an eligible candidate for this life-enhancing treatment.
Dr. Yibin Wang will be recognized for his commitment to learning more about the genetic, molecular and cellular mechanisms behind cardiovascular disease. His research has directly contributed to many clinical studies and new trials for heart diseases.
Researchers at University of Tokyo developed a new plastic material called VPR, which can maintain complex shapes, repair itself with heat, and biodegrade in seawater. The material has improved toughness, shape memory, and recyclability.
The American Heart Association will present Dr. Pradeep Natarajan with the 2023 Joseph A. Vita Award for his groundbreaking research in genetic analysis of cardiovascular disease risk and discovery of new genes responsible for coronary artery disease. His work is propelling the future of preventive cardiovascular medicine.
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
A new study reveals that consumers place a higher value on products from circular economies due to the concept of psychological ownership. This finding suggests that businesses and policymakers can align strategies with consumer values to promote sustainable initiatives.
Researchers at The Wistar Institute have engineered novel monoclonal antibodies that engage Natural Killer cells through Siglec-7, a conserved glyco-immune marker, to fight against cancer. These new approaches demonstrate preclinical feasibility and potential for treating treatment-resistant ovarian cancers.
A new research project will explore the potential for low-lying coral atoll islands to survive the impact of rising sea levels, contradicting previous forecasts. The five-year £2.8m ARISE project will conduct extensive field tests and laboratory experiments in the Maldives and Pacific.
A Finnish study found that maternal microbiota affects foetal development by altering gene activity in the intestine, brain, and placenta. The researchers identified previously unknown compounds in the fetus that are likely to be microbial, shedding light on the significance of the microbiota in individual development and pregnancy.
Researchers have made significant progress in understanding a pathway contributing to liver fibrosis. Paxillin has been found to play a key role in the activation of hepatic stellate cells, leading to excessive extracellular matrix production and scarring. This discovery holds promise for developing new treatments for liver fibrosis.
A new study provides preliminary evidence that an existing drug, α-difluoromethylornithine (DFMO), could be used to treat type 1 diabetes. The drug has already been FDA-approved for other indications and may offer a more convenient treatment option for patients.
A new study reveals that CD8+ T cells control HIV infection by both cytolytic effects and non-cytolytic suppression of virus production. The research team used computer modeling and experiments with macaques to understand the immune system's mechanism in controlling HIV infections.
Dr. Alan Jobe, MD, PhD, is recognized for his pioneering work in neonatal lung diseases, advancing the field of bronchopulmonary dysplasia research. The APS John Howland Award acknowledges his commitment to improving global health outcomes, particularly in low-income countries.
A large cross-sectional study of over 2,800 young men in Switzerland found an association between mobile phone use and lower sperm concentration. While no link was discovered to poor sperm motility or morphology, the results suggest that reduced semen quality may be linked to increased mobile phone usage.
Researchers found that fathers' reported symptoms of anxiety and depression were not associated with worse behavioral and cognitive outcomes in their children. In contrast, slightly higher levels of depressive symptoms among fathers during pregnancy were linked to fewer behavioral difficulties in their child at six to eight years old.
Researchers found that sperm flagellar waveforms are primarily influenced by viscosity rather than shear rate, promoting energy-efficient beating behavior. Sperm adjust their power generation to respond to fluid dynamics, enabling efficient swimming against the flow in high-viscosity media.
A recent meta-analysis found that women in low- and middle-income countries are disproportionately affected by obesity, with risks ranging from 2-3 times higher than men. This disparity is most pronounced in the Sub-Saharan region, where women are up to 10 times more likely to have obesity.
Researchers at the University of Arizona Health Sciences received a $13.1 million grant to study how to improve immune defense in older people. The goal is to create interventions that can help combat age-related decline in T cells, leading to better health outcomes and reduced healthcare expenses.
Researchers have genetically engineered mice with human-like ACE2 protein, allowing them to develop symptoms similar to young humans infected with COVID-19. This breakthrough model has the potential to study disease impact and treatment approaches more effectively.
Researchers will investigate the brain's signaling pathways when xylazine and fentanyl are used together, with the goal of identifying potential therapeutic targets. The study could lead to new strategies for treating individuals struggling with combined substance use.
Scientists identify pyroglutamination, a spontaneous chemical change, in peptide synthesis, leading to an amyloidal structure and potential implications for neurodegenerative diseases like Alzheimer's and Parkinson's. The process favors aggregation of molecules, forming plaques that interrupt neuronal flow.
Researchers introduce FragDPI, a novel method for predicting drug-protein binding affinity by merging sequence information of drugs and proteins. The model yields commendable outcomes compared to baselines, accurately identifying specific interaction parts of drug-target pairs.
Researchers found that cognitive decline quickened by 50% in the first year of the pandemic, with factors like loneliness, depression, and decreased exercise contributing to the impact. The study suggests that lockdowns had a lasting effect on brain health in people aged 50+, raising concerns about increased risk of dementia.
Researchers at Max Planck Institute of Molecular Physiology developed an innovative imaging technique to visualize the cardiac thick filament in its native environment. The resulting high-resolution image reveals new insights into the molecular organization and function of the sarcomere, a crucial component of heart muscle contraction.