A study led by Professor Michael Glickman and postdoctoral researcher Dr. Ajay Wagh found that brain cells transfer toxic UBB+1 protein to neighboring neurons through a mechanism involving p62, potentially accelerating Alzheimer's disease spread
Researchers have found a galaxy cluster with scorching hot gas just 1.4 billion years after the Big Bang, five times hotter than predicted, and containing three supermassive black holes that pumped energy into the surroundings. This discovery could upend current models of galaxy cluster formation and evolution.
A large-scale international study has deciphered a mechanism enabling breast cancer to metastasize to the brain. Researchers identified a specific chromosomal alteration predicting high likelihood of brain metastases and found that the absence of functional p53 gene impairs brain environment adaptation.
Researchers developed a portfolio optimization framework to maximize offshore energy production by identifying optimal locations for wind turbines and marine hydrokinetic technologies. The study found that combining these technologies in suitable locations can significantly reduce costs and increase energy stability.
Scientists develop subseasonal forecasting tools to provide timely, actionable information for governments and industries. These forecasts offer a 'sweet spot' between short-term precision and long-term planning.
Long-term ecological research faces severe threats from lack of funding, data manipulation, and political interference. The report highlights the need for institutional support to establish trustworthy facts and inform policy.
Researchers discovered that sevoflurane impairs neurogenesis and cognitive function by inhibiting fatty acid β-oxidation in neural stem/progenitor cells. Enhancing FAO activity in NSPCs attenuates sevoflurane-induced neurogenesis impairment, suggesting a new mechanism of sevoflurane neurodevelopmental toxicity.
A new study from Brown University researchers reveals that private equity firms have acquired over 500 autism therapy centers across the US, with a focus on states with high rates of autism diagnoses. The findings raise concerns about the potential impact on access to treatment and the quality of care for families seeking services.
A new platform, RootXplorer, enables accurate whole-root-system assessment of soil penetration, critical for breeding crop varieties resilient to soil compaction and drought. The system uses a standardized approach to mimic mechanical impedance and identify genotypes with contrasting tolerance to compaction.
A study applies a multi-criteria decision analysis framework to evaluate three orphan medicinal products, laronidase, emicizumab, and dimethyl fumarate, with highly consistent quantitative scores. The framework offers a transparent and multi-faceted approach to evaluating high-impact drugs for rare diseases within reimbursement systems.
Researchers at Fritz Haber Institute have made significant strides in understanding fuel-cell catalysts under industrially relevant conditions. They discovered that the rate-limiting steps and their degree of rate control change as a function of overpotential and pressure, challenging traditional views on multi-step reactions.
The January 2026 issues of four American Psychiatric Association journals feature groundbreaking research on externalizing disorders, pediatric anxiety, autism, and inflammation-related depression. The studies also explore the potential benefits of psychedelic therapy in suicide prevention.
A new approach enables efficient, real-time wheat phenology detection using compact models and knowledge distillation. The method achieves high accuracy while reducing data and computational demands, suitable for practical agricultural deployment.
Researchers discovered that nicotinic acid can dramatically reduce liver damage caused by ischemia-reperfusion injury. The compound targets damaged mitochondria, reducing markers of liver injury, suppressing inflammation, and promoting mitophagy and mitochondrial biogenesis.
A new study reveals that microplastics are impairing the oceans' ability to absorb carbon dioxide, a process crucial for regulating Earth's temperature. Microplastics also disrupt marine life, weaken the biological carbon pump, and release greenhouse gases as they degrade.
Scientists create natural surfaces with 3D nanowrinkles that control light, liquids, and living cells. The method uses laser polarization to guide the material's organization, enabling precise control over wrinkle formation and applications in bio-inspired surfaces and sensors.
Researchers created a calculator to assess multilingualism, using formulas that consider age of language acquisition and self-rated proficiency. The tool yields scores indicating language dominance and degree of multilingualism, offering a clear and transparent way to understand individual language strengths.
Researchers developed an injectable paste derived from human skin cells to restore breast volume after tumor removal, with less scarring and shorter healing time. The material promotes blood vessel growth and tissue remodeling while keeping inflammation low, making breast reconstruction safer and more accessible.
A CRISPR screen identified 331 essential genes for brain cell generation, including PEDS1 linked to a severe developmental disorder. The study provides a new approach to identifying genes involved in neurodevelopmental disorders like autism and offers insights into gene inheritance patterns.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Researchers at ISTA have found that the zebrafish embryo's geometry is essential for its development, guiding cell division and gene activation. The study's findings could improve IVF embryo assessments by understanding how the embryo interprets its geometry.
A new study found that a drug mimicking the hormone progesterone, megestrol, has anti-cancer activity when used with conventional anti-oestrogen treatment for women with breast cancer. This combination showed a greater decrease in tumour growth rates compared to those treated with an anti-oestrogen only.
The SHASAI project addresses cybersecurity risks in AI systems from design to real-world operation, combining secure hardware and software, risk-driven engineering, and real-world validation. The project will demonstrate its methods and tools in three diverse scenarios, supporting Europe's efforts to promote trustworthy AI.
A team of researchers successfully observed the birth and decay of a highly active solar region, known as NOAA 13664, over three solar rotations. The study provides new insights into the formation and effects of superactive regions on the sun, shedding light on their potential impact on Earth's technology and environment.
A new study from Duke University found that even mild stress before surgery can lead to delirium, uncontrolled pain, and longer hospital stays in older adults. Over 40% of patients reported moderate to high distress levels similar to those with advanced cancer.
A new synthesis of seismic research shows that AI combined with physical principles is rapidly transforming how scientists image the Earth's shallow and crustal structures. The study highlights the need for physics-guided AI frameworks that balance computational efficiency with interpretability.
Researchers have developed a new piezo-photocatalytic material that dramatically improves the removal of carbamazepine from water. The oxygen-doped MoS₂ catalyst achieves rapid and complete degradation within minutes, outperforming conventional photocatalytic approaches.
Insilico Medicine collaborates with Servier to develop novel therapeutics in oncology through AI-driven platform Pharma.AI. The partnership is focused on identifying promising targets and generating molecular structures with desired properties.
Recent advances in CAR-NK cell therapy have expanded its applicability across hematological malignancies, solid tumors, autoimmune diseases, and infectious conditions. CAR-NK cells offer a unique balance between efficacy and safety, with potential applications in cancer and immune-related diseases.
Recent advances in maternal vaccines and long-acting monoclonal antibodies have broadened the scope of RSV prevention, reducing disease burden and improving infant survival outcomes. The expert panel concludes that both strategies demonstrate strong benefit–risk profiles when used appropriately.
A team at East China Normal University directly observes femtosecond-scale quantum coherence transfer from an external laser field to microcavity exciton-polaritons. The study confirms that decoherence in the exciton reservoir is key to losing original coherence.
Researchers have developed a novel class of biomass-derived carbon dots that selectively eradicate Staphylococcus aureus in water. The nanomaterials preferentially bind to pathogen-specific cell wall components, triggering localized oxidative stress and membrane damage while sparing non-target bacteria. This approach offers a sustainab...
A new study has found that membrane filtration is a superior method for collecting submicron aerosols, including bacteria, fungi, and viruses. The research provides practical guidance for accurate airborne pathogen monitoring in hospitals, schools, and other high-risk indoor environments.
The study reveals that SMX enhances nitrous oxide emissions, which are nearly 300 times more potent than carbon dioxide. This increase occurs due to the suppression of nitrogen removal and stimulation of incomplete denitrification in sediments, leading to a significant impact on coastal ecosystems.
The study identifies profound immune dysregulation, chronic inflammation, and impaired cytotoxic function in lymphatic malformations. A Shared CD14⁺CD16⁺ Monocyte Expression Program (SMEP) is uncovered, pinpointing S100A8 as a key druggable target for therapeutic intervention.
The liver's unique immune tolerance is driven by peptide hormones and bile acids, which activate anti-inflammatory responses and foster a tolerogenic phenotype in resident immune cells. This mechanism may explain the liver's reduced rates of transplant rejection but also poses challenges for treating liver infections.
This study reveals how lipid metabolism dysregulation promotes colorectal cancer liver metastasis through a novel YTHDF3-mediated mechanism. Lipid deposition enhances YTHDF3 expression, leading to its degradation and reduced PPARα, which decreases fatty acid oxidation metabolites.
A recent study reveals that FPR2 activation regulates the proliferation and differentiation of intestinal stem cells (ISCs) and transit-amplifying cells, leading to improved epithelial repair. The study also identified a potential therapeutic target for intestinal damage, highlighting the therapeutic potential of FPR2 agonists.
Plant-derived compounds interfere with bacterial quorum sensing to reduce human bacterial pathogens and antibiotic resistance in agricultural soils. The study shows that plant extracts can substantially reduce risks posed by these microbes by disrupting their communication and sharing harmful traits.
Researchers propose that self-sabotaging behaviors like procrastination and perfectionism are rooted in the brain's survival instincts. By processing underlying emotional pain, individuals can break free from self-sabotage loops through self-compassion.
The study investigates regional mechanical variability in porcine pia–arachnoid complex (PAC) using a region-by-region, multi-scale design. Regional differences in mechanical properties are linked to biochemical distributions via two-photon imaging and RNA-seq.
The review explores how multiplayer games, social robots, and virtual agents can advance artificial empathy in therapy and healthcare by embedding interpersonal interaction. It highlights the need for deeper, more seamless closed-loop interaction and emphasizes the importance of emotion recognition, trust, engagement, and rapport.
Autumn straw returning reduces airborne diseases like northern leaf blight by 12.24%, while spring returning is more effective against soil-borne ear rot. The optimal depth for soil-borne pest control is 45 cm, with a combination of full-amount and autumn returning being most beneficial for yield.
HALIMA, a hybrid array for lifetime measurement of neutron-rich nuclei at IMP, enables precise sub-nanosecond measurements using the four-fold FF/β-Ge-LaBr <sub>3 </sub>(Ce)-LaBr <sub>3 </sub>(Ce) coincidence technique. The system reduces Compton continuums and enhances selectivity via fission fragments implantation.
Researchers analyzed brain connectivity data to understand how the brain integrates fast and slow signals. They found that differences in neural timescales across individuals vary in their cognitive abilities.
Jundong Li, an associate professor at the University of Virginia, has received the 2025 Tao Li Award for his significant contributions to data mining and machine learning. His research focuses on developing models that can extract actionable insights from structured data, particularly graphs.
Mircea Stan, a University of Virginia professor, has been awarded the National Academy of Inventors fellowship for his innovative work on low-power computer technology. His contributions have enabled significant energy savings and improved performance in electronic systems.
A recent study by Alice Carter reveals that filamentous algae blooms in the Upper Clark Fork River have a minimal impact on the river's metabolism and function. Instead, smaller epilithic algae are quietly driving the ecosystem, producing healthy conditions for the food web.
Rebuilding coral reef fisheries can help fight global hunger and improve nutrition by increasing sustainable fish yields by nearly 50%. Countries with higher malnutrition indexes can benefit most from recovered reef fish stocks, which could provide enough servings for several million people annually.
A study published in Neurology found that people with weaker and more fragmented circadian rhythms, as well as those who experience a later peak of activity, have an elevated risk of dementia. The study involved over 2,000 participants and followed them for three years to track the development of dementia.
Researchers identify two archetypes of growth arrest that lead to persistence: regulated and disrupted states. The former provides protection from antibiotics, while the latter is marked by vulnerabilities, particularly impaired cell membrane stability. This distinction has significant implications for developing targeted therapies.
Researchers at EPFL developed thermal paper coatings using lignin, a major component of wood, which have low or no toxic signatures. The new formulations match commercial thermal paper performance while showing improved safety profiles.
Researchers used dosage-sensitive genes to detect whole-genome duplication events in ancient angiosperm evolution. Their findings suggest a single ancestral WGD event in seed plants, rather than two independent events, with no additional WGD occurring during angiosperm evolution.
A team of anthropologists offers powerful evidence that Sahelanthropus tchadensis, a seven-million-year-old fossil, was bipedal. The analysis confirmed the presence of traits essential for walking upright, including a femoral tubercle and gluteal muscles. This finding suggests that bipedalism evolved early in our lineage.
Scientists reconstructed ancient genomes of Human betaherpesvirus 6A and 6B from archaeological human remains, confirming their integration into the human genome thousands of years ago. The findings suggest that HHV-6A lost its ability to integrate into human DNA over time.
Researchers found that tangled or irregular collagen at old uterine scars breaks down normal boundary between uterus and placenta, creating permissive environment for abnormal attachment. Persistent inflammation and immune cells also interfere with normal scar remodeling.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
A cohort study found that most children received their first dose of MMR vaccine on time, but the proportion not receiving it by age 2 has increased. Children who missed early vaccinations were more likely to not receive any MMR vaccine by age 2.
Researchers at St. Jude Children's Research Hospital created CHANGE-seq-BE to evaluate the activity and specificity of base editors, a genome editing technology, ensuring safety and accuracy. The technique outperformed conventional approaches and has already been used in clinical work.
A population-based study found that US preterm birth rates have increased among low-income households, with racial disparities exacerbating the issue. The study highlights the need to address racism in reducing preterm birth disparities.