TORONTO -- Resolving complex ethical, social and cultural issues in the early stage of a global health research project or clinical trial can improve the impact and quality of that research, a new report says.
The current practice for researchers is to seek approval for a study or trial from a research ethics board, usually at an academic institution, late in the process when many important decisions have already been made.
But this can leave many complex and messy ethical, social and cultural issues on the table, according to Dr. Jim Lavery, a research scientist in the Li Ka Shing Knowledge Institute of St. Michael's Hospital.
The past 20 years have seen unparalleled investment in large-scale global health science initiatives and international research consortia such as the Human Genome Project and the International AIDS Vaccine Initiative.
Dr. Lavery said these initiatives have resulted in significant scientific advance and have taught researchers a great deal about how such large-scale collaborations should be organized and managed. The Human Genome Project has also shown how the ethical implications of these initiatives could be identified and studied alongside the science.
But in a paper published today in the journal PLOS Neglected Tropical Diseases , Dr. Lavery and colleagues call on researchers, funders, research institutions and managers of large-scale global health initiatives to put more emphasis on understanding the ethical, social and cultural impact of their work and to develop effective approaches to address them.
The report draws on lessons learned by the Ethical, Social and Cultural Program for the Bill & Melinda Gates Foundation's Grand Challenges in Global Health Initiative from 2005-11, for which Lavery served as co-principal investigator, along with Peter Singer at the Sandra Rotman Centre at the University Health Network in Toronto.
Some examples of the challenges addressed by Dr. Lavery and his colleagues in the ESC Program include:
Working with a large international research project to improve the understanding of the impact of malaria, Dr. Claudia Emerson of the ESC Program at the Sandra Rotman Centre developed a "tissue trust" model that recognized the cultural significance of the blood and tissue samples and improved the collaborations with the host country scientists and communities.
"In North America and Europe we tend to focus on privacy issues when blood and tissue samples are involved, but in low- and middle-income countries these samples can have deep cultural significance to communities and therefore ownership and appropriate stewardship of these samples are the main concerns," Dr. Lavery said. "The 'tissue trust' solution is a great example of how our ESC Program works. It was only possible because of a close working relationship with the scientists over several years. It privileged the perspective of the host communities and our collaborators in the South. And it resulted in a practical solution that directly addressed the real ethical problem, and that can be applied and refined for a wide variety of other research projects around the world."
Click here to view the article
About St. Michael's Hospital
St Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, care of the homeless and global health are among the Hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Centre, which make up the Li Ka Shing Knowledge Institute, research and education at St. Michael's Hospital are recognized and make an impact around the world. Founded in 1892, the hospital is fully affiliated with the University of Toronto.
For more information or to interview Dr. Lavery, contact:
Leslie Shepherd
Manager, Media Strategy
Communications and Public Affairs Department
St. Michael's Hospital
416-864-6094
shepherdl@smh.ca
Inspired Care. Inspiring Science.
PLOS Neglected Tropical Diseases