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Unlocking proteins from their cellular shell

08.02.07 | University of Pennsylvania
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Stem Cell Maps of Molecular Modeling Due to Cell Tension
The image on the left is a cell undergoing high tension as it would in certain natural environments. The cell on the right is inhibted and under low tension. Cytoskeleton labeled in red, accessible molecular structures in blue and overlay in pink. Credit: Denis Discher and Colin Johnson

PHILADELPHIA – Applying physical stress to cells, researchers at the University of Pennsylvania have demonstrated that everyday forces can alter the structure of proteins tucked within cells, unfold them and expose new targets in the fight against disease.

Science

Additional Media

Site Mapping of Molecular Structure Changes in Stressed Cells
Reactive dyes are used to "tag" proteins that unfold under force. Credit: Dennis Discher and Colin Johnson

Keywords

Protein Interactions Stem Cells Target Proteins

Article Information

Journal
Science

Contact Information

Jordan Reese
University of Pennsylvania
jreese@upenn.edu

How to Cite This Article

APA:
University of Pennsylvania. (2007, August 2). Unlocking proteins from their cellular shell. Brightsurf News. https://www.brightsurf.com/news/12VDM3X1/unlocking-proteins-from-their-cellular-shell.html
MLA:
"Unlocking proteins from their cellular shell." Brightsurf News, Aug. 2 2007, https://www.brightsurf.com/news/12VDM3X1/unlocking-proteins-from-their-cellular-shell.html.