New York, NY (October 29, 2026) – Today, the American Geriatrics Society (AGS) released a new framework to assist clinicians to safely prescribe obesity medications in older adults.
Organized around a series of cases, the framework offers a practical approach to prescribing obesity medications, including GLP-1 medications, that act through gut-derived hormonal pathways to older adults. While these medications offer promising benefits for weight management, glycemic control, and other health conditions, older adults are under-represented in clinical trials. The AGS framework emphasizes that clinicians should carefully consider age-related factors such as sarcopenia and frailty, risk of lean muscle loss, malnutrition, and dehydration.
This new paper, developed by the AGS Healthy Aging Special Interest Group, discusses key considerations for the use of obesity medications in older adults. The paper explores how to apply the Geriatrics 5Ms Framework (Mind, Mobility, Medications, Multicomplexity, and Matters Most) to incretin therapy in older adults.
The authors emphasize that safe prescribing requires pretreatment assessment of functional status, nutritional adequacy, and cognitive impairment. They recommend that treatment be paired with key co-interventions such as resistance training and adequate dietary protein intake. They note that for some older adults, a team‐based approach, involving a registered dietitian, physical therapist, fitness trainer, and behavioral health professional may be most appropriate.
This paper has been published in the Journal of the American Geriatrics Society and can be found at https://doi.org/10.1111/jgs.70769 .
About the American Geriatrics Society
AGS is a not-for-profit society devoted to improving the health, independence, and quality of life of all older adults. Our 6,000+ members include geriatricians, geriatrics nurse practitioners, social workers, family practitioners, physician associates, pharmacists, and internists who are pioneers in serious illness care for older individuals, with a focus on championing interprofessional teams, eliciting personal care goals, and treating older people as whole persons. AGS is an anti-discriminatory organization. We believe in a society where we all are supported by and able to contribute to communities and where bias and discrimination no longer impact healthcare access, quality, and outcomes for older adults and their care partners. AGS advocates for policies and programs that support the health, independence, and quality of life of all of us as we age. For more information, visit americangeriatrics.org .
Journal of the American Geriatrics Society
Case study
People
Obesity Medications in Older Adults: A Geriatrics 5Ms Framework for Safe and Patient-Centered Prescribing
29-Oct-2026
The authors of the paper declare no conflicts of interest.