A genetic variant found almost exclusively in individuals of Asian descent increases the risk of elevated triglycerides over four-fold, reports a comprehensive study in the August Journal of Lipid Research . In fact, all 11 subjects who carried both copies of this rare variant for apolipoprotein A-V had extremely high and dangerous triglyceride levels in their blood.
Apolipoprotein A-V is a recently discovered lipid-binding protein that likely plays an important role in metabolizing triglycerides. Some population studies with groups in China and Taiwan indicate that a polymorphism in the APOA5 gene (553 G>T shift) is associated with elevated plasma TG levels, which like cholesterol, increase the risk of heart disease.
To get a broader view of this potentially important gene polymorphism, Clive Pullinger and colleagues examined the frequency and impact of this variant in a population of Chinese-Americans, as well as four other Asian-American populations (Japanese, Korean, Southeast Asian, and Pacific Islander).
The researchers examined 541 individuals and found that 15.1% of Chinese-Americans with high plasma TG (>150 mg/dl) carried at least one copy of the 553T variant, compared with only 3.7% of those with normal TG levels; in non-Chinese Asians these values were 13.7% and 5.4%. When calculated, the 553T variant corresponds to a 4.4 and 2.5 times greater risk of elevated TG in Chinese-Americans and other Asians, respectively.
The frequency became even more prevalent at higher levels; 60% of individuals with TG of >500 mg/dl carried the variant, and at 1000 mg/dl the frequency rose to 80%. And the 11 subjects who had the variant in both copies of their APOA5 gene had an average TG concentration of over 2000 mg/dl, which can pose serious health risks.
This specific genetic change seems restricted to Asians, as the researchers studied 779 non-Asian subjects and found only 3 incidences of the 553T variant (2 Caucasian and 1 Hispanic).
From the article: "An apolipoprotein A-V gene SNP is associated with marked hypertriglyceridemia among Asian-American patients" by Clive R. Pullinger, Bradley E. Aouizerat, Irina Movsesyan, Vincent Durlach, Eric J. Sijbrands, Katsuyuki Nakajima, Annie Poon, Geesje M. Dallinga-Thie, Hiroaki Hattori, Lauri L. Green, Pui-Yan Kwok, Richard J. Havel, Philip H. Frost, Mary J. Malloy and John P. Kane
Article link: http://www.jlr.org/cgi/content/abstract/49/8/1846
Corresponding Author: Clive Pullinger, Cardiovascular Research Institute, University of California, San Francisco; Tel: 33-473 608 272; email: clive.pullinger@ucsf.edu
Journal of Lipid Research