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Terahertz endoscopy of hard-to-access objects in the context of neoplasms diagnosis

10.13.25 | Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

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Figure | Pilot endoscopic measurements of the THz optical constants.
Figure| Pilot endoscopic measurements of the THz optical constants. aHollow-core waveguide that uses the anti-resonant reflecting optical waveguiding principle (ARROW) and is based on the polymer-coated sapphire tube.bSchematic of the THz endoscopic system that uses the polymer-coated sapphire waveguide and the reflection-mode backward-wave oscillator (BWO) spectrometer.cReflection spectra of the sapphire window, which is in contact with air, pure water, and pure propylene glycol (PG). Changes i Credit: Gleb M. Katyba et al.

Terahertz (THz) technology was vigorously explored over the past decades. Today, it offers a variety of applications in:

The considerable interest to the THz biomedical applications is driven by the peculiarities of THz-wave–tissue interactions, as compared to other spectral ranges.

In the context of biomedicine, THz waves are strongly absorbed by tissue water. On the one hand, this makes THz waves sensitive to the content and state of tissue water, as an important endogenous marker for various pathologies, including neoplasms. On the other, this limits the depth of THz-wave penetration in tissues by only tens–hundreds of microns. Consequently, THz waves can only probe the superficial tissues.

Due to the limited probing depth, applications of THz spectroscopy and imaging in medical diagnosis can be classified into three modalities based on the diagnostic procedure:

Despite the growing ubiquity of THz technologies, their adoption in these practical fields is hampered by the lack of commercial THz endoscopes and related methods for studying hard-to-access objects. In contrast to the visible and infrared ranges, which benefit from diverse fiber optics technologies and a variety of endoscopic systems, the THz range suffers from an evident lack of such systems, attributed to the nascent state of THz endoscopy hardware and methods.

In a new paper published in Light: Advanced Manufacturing , a research group headed by Kirill Zaytsev (Prokhorov General Physics Institute RAS) reviews two distinct approaches to address the aforementioned problems of THz endoscopy, with an emphasis on medical diagnostics for neoplasms:

The authors also discuss notable examples of THz endoscopic systems, outlining their advantages and drawbacks. In conclusion, they consider the prospects for further research and development in this demanding branch of THz technology and the potential of THz endoscopy in medical applications.

Light: Advanced Manufacturing

10.37188/lam.2025.058

Terahertz endoscopy of hard-to-access objects in the context of neoplasms diagnosis–A review

Keywords

Applied Optics

Article Information

Journal
Light: Advanced Manufacturing
DOI
10.37188/lam.2025.058
Article Title
Terahertz endoscopy of hard-to-access objects in the context of neoplasms diagnosis–A review

Contact Information

Wei Zhao
Light Publishing Center
zhaowei@lightpublishing.cn

Source

Original Source
https://doi.org/10.37188/lam.2025.058

How to Cite This Article

APA:
Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS. (2025, October 13). Terahertz endoscopy of hard-to-access objects in the context of neoplasms diagnosis. Brightsurf News. https://www.brightsurf.com/news/1EO7R52L/terahertz-endoscopy-of-hard-to-access-objects-in-the-context-of-neoplasms-diagnosis.html
MLA:
"Terahertz endoscopy of hard-to-access objects in the context of neoplasms diagnosis." Brightsurf News, Oct. 13 2025, https://www.brightsurf.com/news/1EO7R52L/terahertz-endoscopy-of-hard-to-access-objects-in-the-context-of-neoplasms-diagnosis.html.