New research from the Center for Integration of Science and Industry at Bentley University shows that public companies with products subject to price negotiations in the first two years of the Inflation Reduction Act (IRA) were more profitable than comparable companies in the S&P 500 and that revenues from these drugs were not essential for corporate operations or R&D. This research also shows the estimated margins from sales of these drugs exceeded the average cost of product development, including normal returns, before beginning IRA price negotiations.
The report describes the finances of 11 public companies with products subject to IRA price negotiation in 2024 or 2025 relative to comparable companies in the S&P500. The report also describes US and global revenue generated by these products 2019-2023. Key findings include:
“ This work shows that the companies with products subject to price reduction under the IRA have been extremely profitable and should be able to manage decreases in revenue from these products without compromising operations or future investments in R&D,” said Fred Ledley, Director of the Center for Integration of Science and Industry. “ The results also show that, by the time of the IRA price negotiations, most of these products achieved substantial returns on investment, suggesting that the IRA price reductions could have little impact on future investment in innovation.”
The report , published in Drug Discovery Today , is titled “ Contribution of revenue from drugs subject to price negotiation under the Inflation Reduction Act to the revenue, profit, and returns of pharmaceutical manufacturers. ” Joseph Twomey was the lead author with Drs. Leonhard Kersten, Edward Zhou, and Ledley.
This research builds on previous studies from the Center for Integration of Science and Industry characterizing the profitability of large pharmaceutical manufacturers, the distinct financial structure or smaller biotechnology companies, and the early impacts of the IRA on investments in innovation including R&D spending, equity offerings, and acquisitions.
This work was funded by the National Biomedical Research Foundation through grants to Bentley University and a PhD scholarship from the École doctorale Érasme at Université Sorbonne Paris Nord and travel grant from the Institut Francilien Recherche Innovation Société to Dr. Kersten.
CENTER FOR INTEGRATION OF SCIENCE AND INDUSTRY at Bentley University focuses on advancing the translation of scientific discoveries to create public value. The Center is an environment for interdisciplinary scholarship spanning basic science, data analytics, business, and public policy. For more information, visit bentley.edu/sciindustry and follow us on LinkedIn . The Center for Integration of Science and Industry is an affiliate of the Center for Health and Business at Bentley University.
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Drug Discovery Today
Observational study
Not applicable
Contribution of revenue from drugs subject to price negotiation under the Inflation Reduction Act to the revenue, profit, and returns of pharmaceutical manufacturers
30-Jan-2026
Authors describe no conflicts of interest.