Use of fluoxetine--the most commonly prescribed antidepressant--during pregnancy is linked with a slightly increased risk of malformations in infants, according to a recent analysis of published studies.
In the analysis of 16 studies, infants exposed to fluoxetine during the first trimester had an 18% increased relative risk of major malformations and a 36% increased relative risk of cardiovascular malformations. There were no significant observations of other system-specific malformations in the nervous system, eye, urogenital system, digestive system, respiratory system, or musculoskeletal system.
The findings are published in the British Journal of Clinical Pharmacology .
Similar research was published at an earlier time in the British Journal of Clinical Pharmacology .
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British Journal of Clinical Pharmacology