In a study appearing online on July 14 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation , Christian Buske and colleagues from Ludwig Maximillians University report that AML1-ETO cooperates with FLT3 to potently trigger rapid and aggressive acute leukemia in mice.
This data directly support a pathogenetic model of acute leukemia, which stipulates that an activating mutation in a signal transduction pathway and a mutation in a transcription factor are required for leukemogenesis. This insight into the collaboration of two complementary classes of oncogenes in AML has direct implications for therapeutic interventions as it forms the rationale to test signal transduction inhibitors in leukemias characterized by activating mutations of receptor tyrosine kinases.
Title: The AML1-ETO Fusion Gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice
AUTHOR CONTACT:
Christian Buske
University Hospital Grosshadern, Munich, Germany
Phone: 49-89-7099-402; Fax: 49-89-7099-400; E-mail: buske@gsf.de
View the PDF of this article at: https://www.the-jci.org/article.php?id=24225
Journal of Clinical Investigation