Chemically extracted acellular allogeneic nerve, from which Schwann cells, myelin sheath and disintegrating fragments have been removed, reduced postoperative immune rejection. Simultaneously, chemically extracted acellular allogeneic nerve retains neural substrates and base materials, such as the bottom layer of Schwann cells, which can provide a good scaffold in the process of nerve regeneration. Chemically extracted acellular allogeneic nerve, similar to autologous nerve transplantation, can guide nerve regeneration and provide a favorable local environment for neural tube recanalization. Ciliary neurotrophic factor (CNTF) promotes neuronal survival and prevents nerve degeneration. Researchers at Southern Medical University, China investigated the repair of injured rat sciatic nerve using a chemically extracted acellular allogeneic nerve graft combined with CNTF. They found that chemically extracted acellular nerve grafts combined with CNTF can repair sciatic nerve defects, and that this repair is inferior to autologous nerve anastomosis, but superior to chemically extracted acellular allogeneic nerve bridging alone. The relevant study has been published in the Neural Regeneration Research (Vol. 9, No. 14, 2014).
Article: " Chemically extracted acellular allogeneic nerve graft combined with ciliary neurotrophic factor promotes sciatic nerve repair," by Yanru Zhang1, 2, Hui Zhang3, Kaka Katiella4, Wenhua Huang2 (1 Institute of International Education, Zhengzhou University, Zhengzhou, Henan Province, China; 2 Institute of Clinical Anatomy, Southern Medical University, Guangzhou, Guangdong Province, China; 3 Department of Orthopedics, First Affliated Hospital, Zhengzhou University, Zhengzhou, Henan Province, China; 4 Institute of Clinical Medicine, Zhengzhou University, Zhengzhou, Henan Province, China)
Zhang YR, Zhang H, Katiella K, Huang WH. Chemically extracted acellular allogeneic nerve graft combined with ciliary neurotrophic factor promotes sciatic nerve repair. Neural Regen Res . 2014;9(14):1358-1364
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Neural Regeneration Research