The authors compared serum levels of IGF-I and IGFBP-3 in 230 men who developed lung cancer during the course of the study and in 740 control subjects, and found that men with increased levels of IGFBP-3 at baseline had a reduced risk of lung cancer, whereas increased levels of IGF-I was not associated with increased lung cancer risk. The authors point out that the association was strongest in men with a smoking history.
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