RMPY-008 delivers a structured digital protocol that combines evidence-based psychological interventions with neuroscience-informed sensory modulation. In a randomized controlled study of 103 participants aged 50-65, RMPY-008:
“As a brain plasticity researcher, I’m struck by how quickly we saw connectivity changes in critical networks like the insula, a key brain area modulating the immune system, and prefrontal cortex circuit,” said Prof. Amir Amedi, The School of Psychology and School of Medicine at Reichman University and the principal investigator of the study. "Even more importantly, these connectivity changes were correlated with the emotional and immune improvements, which shows the power of such multisensory digital interventions to retrain the brain and body.”
This large-scale study builds on earlier results of a pilot study published in Nature Scientific Reports (2025) [1] , where the same research team demonstrated that virtual navigation training improved emotional well-being and altered brain connectivity in individuals with SCD, alongside reductions in salivary IL-18 and default mode-salience network interplay.
The implications of the studies extend well beyond cognitive health. Because chronic stress and inflammation are known to negatively impact a wide range of medical conditions-including cardiovascular diseases, autoimmune disorders, metabolic syndrome, cancer, and neurodegenerative illnesses-the demonstrated ability of RMPY-008 to reduce inflammation and improve emotional regulation suggests broader clinical utility.
“As part of our Hybrid Drug™ development strategy, we first validate stand-alone digital interventions and then combine them with target pharmacological treatments,” said Dr. Michal Tsur and Or Shoval, co-founders and co-CEOs of Remepy. "The results from RMPY-008, across mental, brain and immune systems serve as a foundation for our Hybrid Drug clinical pipeline - in Parkinson’s disease, fertility, oncology, and immunology. This is much more than an app - it is a digital antibody.”
npj Digital Medicine
Brain connectivity correlates of the impact of a digital intervention for individuals with subjective cognitive decline on depression and IL-18
26-Feb-2025