The psychiatric condition obsessive-compulsive disorder (OCD) is thought to be associated with alterations to specific nerve-cell circuits in the sub-cortical regions of the brain. Luc Mallet from CNRS UMR 7593 & INSERM U289 and colleagues implanted electrodes into the subthalamic nucleus to improve symptoms of Parkinson's disease in two patients who had a long history of OCD and a more recent history of Parkinson's disease. The first patient had OCD symptoms characterized by obsessive domestic cleaning and a fear of being found dead in a dirty house; the second patient was preoccupied by a checking of locks which took up to two hours a day.
Parkinsonian disability improved after electrode stimulation in both patients; 2 weeks after the procedure their compulsions had disappeared and obsessive symptoms had improved.
Luc Mallet comments: "Despite the partial efficacy of medical treatment, the management of patients with severe OCD remains a challenge. The recovery from OCD that we report in two patients with Parkinson's disease raises the possibility that high-frequency stimulation could improve the functions of subcortical limbic circuitry in patients with severe OCD."
Contact: Professor Yves Agid, Hopital de la Pitie-Salpetriere, 47 Bd de l'Hopital, 75651 Paris, Cedex 13, France;
T) 33-142-162-202;
F) 33-144-243-658 ;
E) agid@ccr.jussieu.fr
Dr Luc MalletCNRS UMR 7593, Hopital de la Pitie-Salpetriere, 47 Bd de l'Hopital, 75651 Paris, Cedex 13, France;
T) 33-142-161-233;
F) 33-142-161-236;
E) lucmallet@free.fr
The Lancet