Research and development costs are a common justification for high cancer drug prices and a new study published by JAMA Internal Medicine offers an updated estimate of the spending needed to bring a drug to the U.S. market.
Sham Mailankody, M.B.B.S., of the Memorial Sloan Kettering Cancer Center, New York, and coauthors analyzed U.S. Securities and Exchange Commission filings for drug companies with no drugs on the U.S. market that received approval from the U.S. Food and Drug Administration for a cancer drug from 2006 through 2015. The analysis by the authors included 10 companies and drugs. They used a different approach to update previous estimates that had ranged from $320 million to $2.7 billion to develop one new drug.
The authors report:
The authors acknowledge study limitations, including a small data set. The analysis also pertains only to cancer drugs and cannot be extrapolated to other sectors where drug development can be harder for biological reasons.
"This analysis provides a transparent estimate of R&D spending on cancer drugs and has implications for the current debate on drug pricing," the article concludes.
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For more details and to read the full study, please visit the For The Media website.
(doi:10.1001/jamainternmed.2017.3601)
Editor's Note: The study includes conflict of interest and funding/support disclosures. Please see the article for conflict of interesting and funding/support disclosures. For more information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.
JAMA Internal Medicine