Researchers report that an implantable skin patch that consists of silk microneedles containing an HIV subunit vaccine led to sustained intradermal vaccine release over 2 weeks, enhanced germinal center B cell responses, and higher serum levels of antigen-specific antibodies and antibody-secreting cells in mice, compared with a typical intradermal injection, suggesting that microneedle skin patches may enhance vaccine effectiveness.
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Article #19-02179: "Enhancing humoral immunity via sustained-release implantable microneedle patch vaccination," by Archana V. Boopathy et al.
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Proceedings of the National Academy of Sciences