Researchers report that cortical neurons derived from human induced pluripotent stem cells, when transplanted into rats with brain lesions similar to those resulting from stroke, functionally integrated into brain circuitry and reversed some of the motor function loss associated with the lesion; the results suggest that grafted stem cell-derived neurons might replace dead cells and restore motor function in stroke, according to the authors.
Article #20-00690: "Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-injured rat brain regulates motor behavior," by Sara Palma-Tortosa et al.
MEDIA CONTACT: Zaal Kokaia, Lund University, SWEDEN; e-mail: Zaal.Kokaia@med.lu.se
###
Proceedings of the National Academy of Sciences