As people age, their immune system becomes less robust. This makes them more susceptible to serious and frequently life-threatening infections with viruses that affect the respiratory tract such as influenza A virus (IAV). Stanley Perlman and colleagues, at the University of Iowa, Iowa City, have now identified a new immune system defect in aged mice that makes them more susceptible than young mice to developing severe clinical disease upon infection with respiratory viruses such as IAV. Importantly, they were able to reverse the defect by inhibiting the immune molecule PGD2. Perlman and colleagues therefore suggest that inhibition of PGD2 could provide a way to improve clinical outcomes in older patients with severe respiratory viral infections and perhaps more importantly enhance the efficacy of flu vaccines in the elderly.
In an accompanying commentary, Thomas Braciale and Taeg Kim, at the University of Virginia, Charlottesville, discuss in more detail the clinical significance of the work of Perlman and colleagues.
TITLE: Age-related increases in PGD2 expression impair respiratory DC migration, resulting in diminished T cell responses upon respiratory virus infection in mice
AUTHOR CONTACT:
Stanley Perlman
University of Iowa, Iowa City, Iowa, USA.
Phone: 319-335-8549; Fax: 319-335-9006; E-mail:
Stanley-perlman@uiowa.edu .
ACCOMPANYING COMMENTARY
TITLE: Slowing down with age: lung DCs do it too
AUTHOR CONTACT:
Thomas J. Braciale
University of Virginia, Charlottesville, Virginia, USA.
Phone: 434-924-1219; Fax: 434-924-1221; E-mail: tjb2r@virginia.edu .
View this article at: http://www.jci.org/articles/view/61367?key=d308c58ebf42286ad3a5
Journal of Clinical Investigation