Chemodynamic therapy is a cancer treatment method based on Fenton/Fenton-like reaction. The exploration of peroxidase materials, which is for chemodynamic therapy, is an important research topic in the field of materials science.
In a new perspective article published on The Journal of Physical Chemistry Letters, Prof. WANG Hui from Hefei Institutes of Physical Science (HFIPS) , collaborated with professor from The City University of New York, summarized the latest research progress of metal nanozymes and carbon-based nanozymes for peroxidase mimics.
In this paper, after analyzing the reaction mechanism of metal nanozyme, and concluding the effects of the structure and surface properties of carbon-based nanozymes on its electron transfer and peroxidase-like activity, they outlined development direction of carbon nanomaterials in the chemodynamic therapy of cancer.
They first reviewed the design of high-performance metal-doped carbon-based peroxidase in recent years. Doping metal into carbon-based nanomaterials may be a feasible design to solve the problems of metal nanozyme aggregation. However, the author believes that as the nanozyme contains metals, it will cause potential problems to the human body. Carbon-based nanomaterials are difficult to transfer electrons, resulting in a low peroxidase rate. Therefore, figuring out how to increase the peroxidase rate of carbon-based nanozymes is the focus of current scientific research.
They predicts that the future research direction of nanozymes should be extremely small sized carbon-based nanomaterials with stability and long-term safety, high peroxidase like activity and excellent near-infrared emission and absorption properties.
"By combining tumor microenvironment response chemodynamic therapy with NIR photothermal therapy and fluorescence imaging on a single nano platform,” said WANG Hui, “this metal-free carbon-based nanozymes can minimize side effects and improve antitumor efficacy."
The Journal of Physical Chemistry Letters
Progress and Perspective on Carbon-Based Nanozymes for Peroxidase-like Applications
2-Dec-2021