As demand for non-surgical aesthetics (NSA) grows globally, a new review uncovers how these procedures impact the very foundation of skin health. Researchers analyzed six common NSA treatments—mesotherapy, photorejuvenation, fractional and picosecond lasers, Thermage, and microfocused ultrasound—and found that while they improve skin appearance, they often challenge the skin’s ability to stay balanced, defend itself, and heal.
“Healthy skin relies on three core functions: equilibrium, resistance, and self-healing,” explains corresponding author CUI Bin of MOYAL LAB. “NSA procedures, though minimally invasive, can temporarily disrupt these functions, leading to redness, sensitivity, infection risk, or pigmentation issues.”
The study details how each procedure interacts with skin biology. For example, lasers may compromise barrier integrity and alter microbial balance, while injectables can trigger immune reactions. Importantly, the team also outlines targeted post-care strategies—such as barrier repair creams, strict sun protection, and microbiome-friendly products—to help skin recover safely and effectively.
“Understanding these interactions allows clinicians to personalize treatments and aftercare, reducing complications while maximizing benefits,” adds HAN Ruifang, first author of the review. “It’s not just about enhancing beauty—it’s about preserving skin health.”
Journal of Dermatologic Science and Cosmetic Technology
Literature review
Not applicable
The impacts of non-surgical aesthetics on the core functional triad of skin
26-Jun-2025
The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Authors Ruifang Han, Xiang Li, Juntong Li, Shuyu Wang, Shengnan Li, Junpeng Yuan, Jian Zhou, Bin Cui are employed by the company Shenzhen Moore Vaporization Health & Medical Technology Co., Ltd. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.