During failure of core protein quality control in the nematode C. elegans , a specialized anti-aggregation mechanism relying on pathogen response factors and lysosomal mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity.
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In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology : http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002284
Article Title: A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C . elegans
Author Countries : Germany, United Kingdom
Funding: see manuscript
PLOS Biology
Competing interests: The authors have declared that no competing interests exist.