The endocrine system plays a crucial role in regulating physiological processes and maintaining homeostasis. While previous studies have examined aging in individual endocrine organs, a comprehensive investigation across multiple endocrine tissues at single-cell resolution has been lacking. This study established the first single-cell aging atlas of the endocrine system, revealing conserved and organ-specific aging mechanisms while identifying novel regulatory pathways.
Key findings from the study include:
This study provides the first comprehensive single-cell atlas of endocrine aging, revealing both shared and organ-specific aging mechanisms. The findings not only advance understanding of endocrine aging but also suggest that immune-endocrine interactions represent a key node for potential interventions. Future studies will explore whether aged endocrine organs secrete systemic aging factors, potentially establishing endocrine tissues as central regulators of organismal aging. The work establishes a foundation for developing targeted strategies to maintain endocrine function during aging and potentially modulate systemic aging processes.
Protein & Cell
Experimental study
Animal tissue samples
A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse
1-Sep-2025