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In utero particle exposure and respiratory illness

02.11.19 | Proceedings of the National Academy of Sciences

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H&E-Stained Section of Lungs in C57Bl/6 Neonatal Mice
This is an H&E-stained section of lungs in C57Bl/6 neonatal mice exposed in utero to filtered air and challenged with PBS (control) show minimal to no inflammation, as expected. Credit: Carmen Lau

Researchers report that compared with mice exposed to filtered air in utero, mice exposed to ultrafine particles (UFP) in utero failed to develop strong immune responses to house dust-mite allergens, and at four weeks old, had less bronchiole inflammation and fewer white blood cells in their bronchoalveolar lavage fluid; this immune suppression was more pronounced in a mouse strain sensitive to oxidative stress, indicating that maternal oxidative stress responses to UFP exposure may alter fetal immune development, and in utero UFP exposure may predispose neonates to respiratory infections.

Article #18-16103: "In utero ultrafine particulate matter exposure causes offspring pulmonary immunosuppression," by Kristal A. Rychlik et al.

MEDIA CONTACT: Natalie M. Johnson, Texas A&M University, College Station, TX; tel: 979-436-9325; email: natalie.johnson@sph.tamhsc.edu

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Proceedings of the National Academy of Sciences

Additional Media

Neonatal Mice Exposed In Utero To Ultrafine Particles (UFPs) And Challenged With HDM
Neonatal mice exposed in utero to ultrafine particles (UFPs) and challenged with HDM showed an inflammatory response that was similar in character to the control mice, but on average was less pronounced in severity of inflammation, indicating an overall reduced pulmonary inflammatory response. Credit: Image courtesy of Carmen Lau.
Neonatal Mice Exposed In Utero To Filtered Air And Challenged With The Allergen House Dust Mite
Neonatal mice exposed in utero to filtered air and challenged with the allergen house dust mite (HDM) showed the most marked eosinophilic and histiocytic peribronchiolar and perivascular inflammation, which is expected in an HDM challenge model. Credit: Image courtesy of Carmen Lau.

Keywords

Allergic Inflammation Oxidative Stress Stress Responses

Article Information

Journal
Proceedings of the National Academy of Sciences

Contact Information

Natalie M. Johnson
natalie.johnson@sph.tamhsc.edu

How to Cite This Article

APA:
Proceedings of the National Academy of Sciences. (2019, February 11). In utero particle exposure and respiratory illness. Brightsurf News. https://www.brightsurf.com/news/LM24QWRL/in-utero-particle-exposure-and-respiratory-illness.html
MLA:
"In utero particle exposure and respiratory illness." Brightsurf News, Feb. 11 2019, https://www.brightsurf.com/news/LM24QWRL/in-utero-particle-exposure-and-respiratory-illness.html.