"These studies identify the T-type calcium channel as a new target for G-protein beta gamma subunits," Barrett said. "The extraordinary specificity of the interaction between these regulatory molecules could be operative in many types of cells and provides exciting insight into the highly selective ways in which cells work. Knowledge of these interactions will lead to the development of new and more specific drugs in the future."
Joshua T. Wolfe, a graduate student whose work is supported by the American Heart Association, conducted much of the work for this research. Support for the research also came from the National Institutes of Health and the University of Virginia Cardiovascular Research Center.
Nature