Embargoed for release until 5:00 p.m. ET on Monday 19 January 2026
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Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine . The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.
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1. 58% of patients affected by 2022 mpox outbreak report lasting physical symptoms
Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-25-00036
Summary for Patients: https://www.acpjournals.org/doi/10.7326/ANNALS-25-00036-PS
URL goes live when the embargo lifts
A cohort study of over 300 adults either diagnosed with mpox between May 2022 to January 2023 (post-MPX) and or who were at risk but never infected (no-MPX) found that more than half of those diagnosed with mpox during the 2022 outbreak still had lingering physical effects 11 to 18 months later. Most reported appearance-related changes, and some continued to experience anorectal or urinary problems. The study is published in Annals of Internal Medicine .
Researchers from the Centers for Disease Control and Prevention, Columbia University Division of Infectious Diseases, and University of Texas Health Science Center Houston sought to understand the long-term psychosocial and behavioral impact between at-risk persons who had or did not have mpox during the 2022 mpox outbreak. The researchers recruited post-MPX and no-MPX participants from health centers in New York City, NY and Houston, TX to complete psychosocial and behavioral self-assessments followed by a clinical evaluation among the post-MPX group. The study found that 58% of those infected had at least one persistent symptom. Among post-MPX participants with appearance-related sequelae, the extent of sequelae was relatively low, with most having fewer than 10 scars or sites of discoloration and 2 or fewer body sites involved. Thirteen percent of post-MPX participants experienced ongoing physical function changes, and 2% had their activities of daily living affected. The findings provide context into the enduring physical and psychosocial effects that may occur because of mpox.
Media contacts: For an embargoed PDF, please contact Gabby Macrina at gmacrina@acponline.org. To contact corresponding author Preetam Cholli, MD, please submit a CDC Request for Comment Form .
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2. Bariatric surgery shows advantage over medical therapy for diabetes across all social backgrounds
Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-24-01882
In a long-term analysis of people with type 2 diabetes, researchers found that bariatric surgery led to greater weight loss and better blood sugar control than medical and lifestyle treatment, regardless of whether participants lived in socially disadvantaged neighborhoods. The findings suggest social vulnerability level does not change the benefits of bariatric surgery over medical therapy in those with type 2 diabetes. The study is published in Annals of Internal Medicine .
Researchers from the Joslin Diabetes Center and Harvard Medical School and colleagues analyzed data from 258 adults with type 2 diabetes who were enrolled in randomized trials comparing bariatric surgery with medical therapy to determine if social vulnerability influenced the effectiveness of bariatric surgery compared to medical and lifestyle interventions including individualized nutrition counseling and instruction on exercise and self-monitoring of glucose. They linked participants’ ZIP codes to the Area Deprivation Index to determine social vulnerability and analyzed changes in weight and hemoglobin A1c levels over 7 to 12 years. Bariatric surgery showed greater long-term effectiveness than medical and lifestyle interventions for both glycemic and weight loss outcomes across all levels of social vulnerability. However, the researchers did not find statistically significant differences in the comparative advantage of surgery over medical therapy by ADI levels.
Media contacts: For an embargoed PDF, please contact Gabby Macrina at gmacrina@acponline.org. To contact corresponding author Mary Elizabeth Patti, MD please email mary.elizabeth.patti@joslin.harvard.edu.
Also new this issue:
GRADE Guidance: Update on Developing Good Practice Statements in Guidelines
Omar Dewidar, HBSc, MSc, et al.
Research and Reporting Methods
Abstract: https://www.acpjournals.org/doi/10.7326/ANNALS-25-00431
Editorial: https://www.acpjournals.org/doi/10.7326/ANNALS-25-04964
Annals of Internal Medicine
News article
People
Long-Term Mpox Sequelae 11 to 18 Months After Acute Illness: A Cohort Study in Two U.S. Cities
20-Jan-2026