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Stem cell transplantation and fertility in mice

03.30.20 | Proceedings of the National Academy of Sciences
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Congenitally infertile Cldn11 KO testis transplanted with Cldn11 KO testis cells.
Congenitally infertile Cldn11 KO testis transplanted with Cldn11 KO testis cells. Credit: Image credit: Takashi Shinohara

A study of chemically castrated mice deficient in the Cldn11 gene, which regulates functioning of the blood-testis barrier, finds that transplantation of spermatogonial stem cells can restore the development of fertile sperm, suggesting that such stem cell transplantation may help treat some forms of male infertility, according to the authors.

Article #19-14963: "Autologous transplantation of spermatogonial stem cells restores fertility in congenitally infertile mice," by Mito Kanatsu-Shinohara, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura and Takashi Shinohara.

MEDIA CONTACT: Takashi Shinohara, Kyoto University, JAPAN; e-mail: tshinoha@virus.kyoto-u.ac.jp

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Proceedings of the National Academy of Sciences

Additional Media

Offspring born after microinsemination using Cldn11 KO sperm generated in Cldn11 KO testis.
Offspring born after microinsemination using Cldn11 KO sperm generated in Cldn11 KO testis. Credit: Image credit: Narumi Ogonuki

Keywords

Sperm Stem Cell Development Transplantation

Article Information

Journal
Proceedings of the National Academy of Sciences

Contact Information

Takashi Shinohara
tshinoha@virus.kyoto-u.ac.jp

How to Cite This Article

APA:
Proceedings of the National Academy of Sciences. (2020, March 30). Stem cell transplantation and fertility in mice. Brightsurf News. https://www.brightsurf.com/news/LRD64PG8/stem-cell-transplantation-and-fertility-in-mice.html
MLA:
"Stem cell transplantation and fertility in mice." Brightsurf News, Mar. 30 2020, https://www.brightsurf.com/news/LRD64PG8/stem-cell-transplantation-and-fertility-in-mice.html.