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Wuda granule improves the gastrointestinal motility via gut-brain axis in beagle dogs

11.15.25 | FAR Publishing Limited

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Figure 1A. Gastrointestinal MMC curves chart in beagle dogs. Figure 1B. Gastrointestinal motility curve chart in beagle dogs before and after lateral ventricular injection of WDG in awake and fasted state. Figure 1C. Gastrointestinal motility curve chart
Figure1A:In the awaken and fasted state, typical MMC contractile movements were seen in the gastric body, sinus, duodenum and jejunum in beagle dogs, while the colon was dominated by intermittent clustered contractions and resting periods.Figure 1B:In awake and fasted state, the gastric body, In awake and fasted state, after the resting phase of MMC phase I, injections of WDG at 5 mg in the lateral ventricles were observed to show more intense contractions of longer duration than in the anesthet Credit: Zhi Jiang, Xing Li ,Qicheng Chen, Zhiqiang Chen, Lixing Cao, Hailin Tang

This study investigated the mechanism of Wuda granule (WDG) on gastrointestinal (GI) motility in beagle dogs. Stress sensors implanted in the stomach, duodenum, jejunum, and colon recorded contractile activity. Lateral ventricular administration of WDG (5mg) significantly enhanced contractile motility in all recorded GI regions in awake dogs; this effect was attenuated under intravenous anesthesia. The prokinetic effect of central WDG was completely blocked by intravenous atropine infusion [50 μg/(kg·h)]. Bilateral cervical vagotomy prolonged the migrating motor complex cycle, weakened gastric phase III contractions, and abolished the WDG-induced enhancement specifically in the stomach. However, WDG still enhanced motility in the duodenum, jejunum, and colon post-vagotomy. Transmission electron microscopy confirmed no intestinal structural changes induced by WDG. WDG enhances GI contractility centrally, primarily via activation of vagal cholinergic pathways for the stomach, while exerting effects on the lower GI tract through additional, non-vagal mechanisms.

10.1002/imm3.70016

Experimental study

Animals

Wuda granule improves the gastrointestinal motility via gut-brain axis in beagle dogs

14-Nov-2025

The authors declare no conflict of interest, financial or otherwise.

Keywords

Health and Medicine

Article Information

DOI
10.1002/imm3.70016
Method of Research
Experimental study
Subject of Research
Animals
Article Publication Date
2025-11-14
Article Title
Wuda granule improves the gastrointestinal motility via gut-brain axis in beagle dogs
COI Statement
The authors declare no conflict of interest, financial or otherwise.

Contact Information

Chris Zhou
FAR Publishing Limited
editorial@fargroups.com

Source

Original Source
https://onlinelibrary.wiley.com/doi/10.1002/imm3.70016

How to Cite This Article

APA:
FAR Publishing Limited. (2025, November 15). Wuda granule improves the gastrointestinal motility via gut-brain axis in beagle dogs. Brightsurf News. https://www.brightsurf.com/news/LRDERRM8/wuda-granule-improves-the-gastrointestinal-motility-via-gut-brain-axis-in-beagle-dogs.html
MLA:
"Wuda granule improves the gastrointestinal motility via gut-brain axis in beagle dogs." Brightsurf News, Nov. 15 2025, https://www.brightsurf.com/news/LRDERRM8/wuda-granule-improves-the-gastrointestinal-motility-via-gut-brain-axis-in-beagle-dogs.html.