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Designing a sulfur vacancy redox disruptor for photothermoelectric and cascade‑catalytic‑driven cuproptosis–ferroptosis–apoptosis therapy

09.15.25 | Shanghai Jiao Tong University Journal Center

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Designing a Sulfur Vacancy Redox Disruptor for Photothermoelectric and Cascade-Catalytic-Driven Cuproptosis–Ferroptosis–Apoptosis Therapy
The glycometabolism and enzyme activity of Cu2MnS3-x-PEG/glucose oxidase (MCPG) achieve a cascade catalytic reaction, continuously replenishing the deficient H2O2and O2and inducing adequate reactive oxygen species supply.Density functional theory calculations indicate that Mn doping facilitates the structural reconstruction and evolution of sulfur vacancies (SV) sites, leading to a remarkable increase in the catalytic activity of Cu2MnS3-x.Under 1064 nm laser irradiation, MCPG with abundant SVdr Credit: Mengshu Xu, Jingwei Liu, Lili Feng, Jiahe Hu, Wei Guo, Huiming Lin, Bin Liu, Yanlin Zhu, Shuyao Li, Elyor Berdimurodov, Avez Sharipov, Piaoping Yang.

As cancer evolves, the demand for intelligent therapeutics that integrate energy conversion, metabolic interference, and immune activation intensifies. Now, researchers from Harbin Engineering University and Harbin Normal University, led by Professor Piaoping Yang, Professor Lili Feng, and Professor Wei Guo, have delivered a comprehensive study on biodegradable Cu 2 MnS 3-x -PEG/glucose oxidase (MCPG) nanosheets that realize triple-modal cell death. This work offers a blueprint for next-generation nanotherapies that break the “resistance ceiling” of single-mechanism treatments.

Why MCPG Matters

Innovative Design and Features

Applications and Future Outlook

This comprehensive study delivers a roadmap for integrating photothermoelectric physics, defect engineering, and metabolic intervention in one nanoplatform. It underscores the importance of interdisciplinary collaboration among materials science, catalysis, and tumor immunology to propel the field forward.

Stay tuned for more groundbreaking work from Professor Piaoping Yang’s team at Harbin Engineering University!

Nano-Micro Letters

10.1007/s40820-025-01828-8

Experimental study

Designing a Sulfur Vacancy Redox Disruptor for Photothermoelectric and Cascade-Catalytic-Driven Cuproptosis–Ferroptosis–Apoptosis Therapy

4-Jul-2025

Keywords

Sulfur

Article Information

Journal
Nano-Micro Letters
DOI
10.1007/s40820-025-01828-8
Method of Research
Experimental study
Article Publication Date
2025-07-04
Article Title
Designing a Sulfur Vacancy Redox Disruptor for Photothermoelectric and Cascade-Catalytic-Driven Cuproptosis–Ferroptosis–Apoptosis Therapy

Contact Information

Bowen Li
Shanghai Jiao Tong University Journal Center
qkzx@sjtu.edu.cn

Source

Original Source
https://link.springer.com/article/10.1007/s40820-025-01828-8

How to Cite This Article

APA:
Shanghai Jiao Tong University Journal Center. (2025, September 15). Designing a sulfur vacancy redox disruptor for photothermoelectric and cascade‑catalytic‑driven cuproptosis–ferroptosis–apoptosis therapy. Brightsurf News. https://www.brightsurf.com/news/LVDGGE5L/designing-a-sulfur-vacancy-redox-disruptor-for-photothermoelectric-and-cascadecatalyticdriven-cuproptosisferroptosisapoptosis-therapy.html
MLA:
"Designing a sulfur vacancy redox disruptor for photothermoelectric and cascade‑catalytic‑driven cuproptosis–ferroptosis–apoptosis therapy." Brightsurf News, Sep. 15 2025, https://www.brightsurf.com/news/LVDGGE5L/designing-a-sulfur-vacancy-redox-disruptor-for-photothermoelectric-and-cascadecatalyticdriven-cuproptosisferroptosisapoptosis-therapy.html.