A new study found a link between chronic HBV and progression to cancers other than hepatocellular carcinoma, specifically Non-Hodgkin Lymphoma (NHL) and Cholangiocarcinoma. Higher levels of viral replication were associated with increased risk, indicating a potential causal effect.
A study evaluating INT-747 added to ursodeoxycholic acid found significant improvements in liver enzyme levels in patients with primary biliary cirrhosis. The results suggest a potential new treatment option for this chronic disease, which damages bile ducts and leads to liver scarring.
Researchers found that dark chocolate reduced damage to blood vessels in cirrhotic patients and lowered blood pressure. In contrast, white chocolate had no beneficial effects on portal hypertension.
A study of liver transplant patients found that HIV positive individuals have similar survival rates to those who are HIV negative. However, co-infection with hepatitis C virus significantly predicts poorer outcomes in this patient group, emphasizing the need for targeted antiviral therapy.
A new study shows radioembolisation to be a safe and effective treatment for patients with advanced HCC, achieving partial response rates of up to 80% and comparable survival rates to systemic therapy. The technique may offer a novel palliative therapeutic approach for those with limited options.
A DNA-based therapeutic vaccination has shown antiviral effects in patients with chronic hepatitis C, with 67% experiencing significant reductions in viral load. The vaccine, developed using naked DNA delivered by electroporation, was found to induce immune responses and activate the host T cell response in patients.
The study identified GP130 somatic activating mutations in 65% of inflammatory hepatocellular tumours, revealing a new pathway of tumourigenesis. These mutations also enabled the refinement of molecular classification of hepatocellular tumors.
Liver disease is the most prevalent cause of alcohol-related deaths in Portugal, accounting for 28.3% of related deaths. The study also found that alcohol-related diseases account for 1.25% of health expenditure in Portugal, totaling €189.2 million in direct costs.
A new study reveals that type 2 diabetes, obesity, and hypertension are associated with higher mortality rates in hepatitis C patients. The research found that metabolic syndrome components, such as diabetes and high BMI, were linked to increased overall and liver-related mortality in HCV-infected patients.