More than just a DNA repair deficiency syndrome
Researchers found that the CSB protein, previously thought to be solely responsible for DNA repair, also enhances acetylation of alpha-Tubulin and regulates autophagy. HDAC inhibition restores balance, improving skin symptoms in mouse models. Further studies aim to explore its potential treatment for Cockayne syndrome.
SourceLeibniz Institute for Environmental Medicine·JournalScience Translational Medicine·DateAug 29, 2018