Researchers have developed a new method to genetically correct stem cells in just two weeks, compared to conventional approaches that take over three months. This breakthrough could make personalized stem cell therapies possible for patients with genetic disorders, such as severe combined immunodeficiency and retinal degeneration.
A team of scientists developed a new system using stem cells to model features of the developing human brain that could be targeted by toxic chemicals or drugs. The approach, described in PNAS, uses machine learning to build a predictive model from RNA sequencing data collected from neural tissue constructs exposed to different chemicals.
A new statistical approach, called Oscope, identifies oscillating genes in single-cell RNA-sequencing experiments by examining cells from an unsynchronized population. The technique captures one base cycle of each group of cyclic genes, offering a practical way to profile distinct groups of genes that play a cyclical role.
Researchers at Morgridge Institute for Research discovered a method to impose an immortal-like state on mouse progenitor cells responsible for producing blood and vascular tissue. The breakthrough enables the creation of functional endothelial, blood, and smooth muscle cells, paving the way for cell-based therapies and drug screening.