A team of scientists has identified a cluster of 88 genes that may act as molecular markers for the developmental potential of different stem cell types and stages. These findings are consistent with previous research on cellular development and plasticity, and shed light on the molecular pathways guiding development.
Researchers solved the structure of aquaporin Z, a water channel found in Escherichia coli that conducts only water at high rates. The protein's unique architecture and strategically positioned amino acid residues restrict the flow of larger molecules, allowing it to maintain osmotic equilibrium.
The study found functionally related genes were co-expressed across six distantly related organisms, including bacteria, yeast, and human. The researchers discovered conserved transcription modules that provide clues to the evolutionary building blocks generating diversity in cells.
Researchers found that multiple caspases and regulators are required for proper sperm formation in fruitflies, highlighting a non-apoptotic process. This discovery could provide insights into male infertility and suggest possible treatments.
The C. briggsae genome sequence enhances biologists' ability to mine C. elegans for biological insights, revealing new genes and functional elements. The study also highlights the rapid evolution of C. elegans and C. briggsae genomes compared to mammals.
A study identified variants of the BMP2 gene as genetic risk factors for osteoporosis, approximately tripling the likelihood of developing the disease. The findings were replicated in an independent cohort, suggesting a strong association between the gene's variants and increased risk of osteoporotic fractures.
Researchers found a genetic link between GAD2 variants and obesity. The study suggests that overexpression of the GAD2 gene may increase GABA levels in the hypothalamus, leading to increased orexigenic effects and overeating.
Researchers created mouse models to study PTEN's impact on prostate cancer progression. Subtle reductions in PTEN dose produced progressive changes in the biology of tumors, with mice having no functional PTEN genes showing the most invasive and aggressive cancers.
PLoS Biology features peer-reviewed research articles on diverse topics, making outstanding science freely available worldwide. The journal's open-access model aims to increase interdisciplinary collaboration, speed scientific discovery, and potentially save lives.
Researchers have used a bioinformatics approach to identify additional microRNA targets in fruit fly Drosophila, increasing the number of known targets from three to over 60. The study provides an important step towards understanding how microRNAs affect protein composition in animal cells.
Miguel Nicolelis and colleagues present results from long-term studies in monkeys, showing that the same set of brain cells can control two distinct movements using a brain-machine interface. This finding has important practical implications for spinal-cord patients, offering flexibility in introducing electrodes or functional enhancem...
Researchers used mathematical modeling to study the Wnt pathway, a complex signaling system involved in embryonic development and carcinogenesis. The model revealed surprising differences in concentrations of key proteins, suggesting that breakdowns in cellular communication play a role in cancer development.
A new approach to analyzing bacterial genomes has enabled the reconstruction of evolutionary events and the diversification of bacterial species over a billion years. This method uses gene indicators to chart the structure and substance of genomes, providing valuable insights into genomic evolution.
Scientists have found that brain clock cells in fruit flies rely on intercellular communication to sustain their circadian rhythms, even in the absence of light. The study also shows that a protein called PDF plays a crucial role in coordinating this process.
Research reveals Borneo's elephants are genetically distinct from other Asian elephants, suggesting they may have parted ways 300,000 years ago. This classification changes the focus of their conservation, as their habitats are increasingly disrupted by human expansion.
A recent study published in PLOS Biology tracked the genomic activity of Plasmodium falciparum in human red blood cells, revealing a surprisingly simple pattern of gene expression. This finding could lead to the identification of the biological function of unknown genes and provide new insights into the life cycle of malaria parasites.