Researchers have discovered a novel physiological role for UG in mice, suggesting its essentiality in preventing kidney fibrosis and neonatal BPD. UG deficiency leads to inflammation and fibrosis of lung tissue, resulting in respiratory inhibition.
Researchers have discovered a key role for the TIGR protein in non-hereditary forms of glaucoma, which may lead to novel diagnostic tools and treatments. The study found that exposure to steroid drugs or oxidative stress increased TIGR protein production, contributing to elevated intraocular pressure.
A groundbreaking study has identified a gene responsible for primary congenital glaucoma, a condition affecting 1 in 2,000 to 1 in 10,000 births. The discovery holds promise for early diagnosis and treatment, potentially preventing blindness, with the potential to be applied to adult-onset primary open angle glaucoma.
A study published in Science journal demonstrates the efficacy of vascular targeting agents (VTAs) in treating large solid tumors. VTAs selectively occlude tumor vasculature, causing massive tumor cell death and advanced necrosis within 72 hours. The treatment is well-tolerated and results in complete or partial tumor regressions in mice.