Researchers discovered glypican-3 loss induces overgrowth through Sonic Hedgehog, a growth factor stimulating cancer growth in rare disorder SGBS. This finding opens doors for novel treatments to inhibit overgrowth activity benefiting SGBS patients and GPC3-related cancer patients.
PET imaging enhances lung cancer staging by providing complementary information on biochemical processes, accurately differentiating between benign and malignant tumors as small as 1 centimeter. The study also found PET to be more effective for mediastinal staging in non-small cell lung cancer.
Researchers have discovered blood plasma proteins that rise and fall after treatment with antiangiogenic drugs, which may be used as surrogate biomarkers to predict the optimal dose. The study also found molecular changes in normal mice, suggesting that the body's response is not solely tumor-dependent.