Articles tagged with Three Dimensional Modeling
Researchers developed a 3D printing method to preserve coral reefs, using natural structure data and environmental DNA sampling. The process creates customizable structures that can be tailored to specific reef environments, promoting biodiversity and supporting regrowth.
The April issue of SLAS Discovery highlights innovative approaches to accelerating lead identification for pancreatic cancer therapies. Authors explore the potential of completely scaffold-free 3D models and automated organoid assays to improve disease modeling and drug discovery.
The new computational tool, AF2Complex, predicts the structure of protein complexes and their interactions, offering insights into biomolecular mechanisms. The model is based on AlphaFold 2 and performs well in predicting protein structures and complex formations.
Two new methods for producing high-resolution visualizations of small artefacts are presented, allowing anyone to create high-quality images and models with minimal effort and cost. The protocols provide detailed workflows for photographic acquisition and processing, enabling replicability and reproducibility in the field of archaeology.
New research suggests diverse microbial life existed on Earth at least 3.75 billion years ago, dating back to a time when the planet was still forming. The study, led by UCL researchers, analyzed ancient rock formations and found evidence of complex structures that could not have been created through chemical reactions alone.
A team of researchers developed a novel chip-based infection model to study invasive aspergillosis, a mold infection that affects the lungs. The model allows for live microscopic observation of damage caused by fungal hyphae and the response of immune cells.
A new deep learning-based model called Highlights on Target Sequences (HoTS) predicts binding between drugs and target molecules, providing interpretable results. The model can predict target proteins' binding regions and interactions with drugs without a 3D complex.
Researchers used X-ray computed microtomography to produce stunning 3D reconstructions of the proteus' head, revealing extensive changes in sensory organs and physical appearance. The study provides detailed information about evolutionary-designed adaptations for surviving in lightless caves.
Researchers at the University of Tokyo have developed a new model to aid interpretation of atomic resolution molecular images. The Z-correlated molecular model accurately fits imaging data and helps chemists analyze electron microscope images without theoretical calculations.
The University of Texas at El Paso establishes a new Systems Modeling and Simulation concentration, enhancing students' skills in data analytics, computer simulation, and machine learning. The program aims to train students for innovative industries with rapidly changing environments.
Researchers at KTH Royal Institute of Technology created a 3D model of living brain cancer using cavitation molding technique. The model closely replicates human tissue and maintains cell viability, making it suitable for drug screening.
Scientists at Michigan Medicine have developed a new way to grow tiny models of organs, called organoids, using a simple suspension culture. This breakthrough improves the understanding of human development and could lead to new insights into disease.
Researchers developed a novel method of measuring aortic growth, called vascular deformation mapping, which outperforms standard manual rating methods. The technique uses high-resolution CT imaging to calculate three-dimensional changes in the aortic wall, achieving an accuracy of less than 1 millimeter.
University of Utah researchers measured 14 rock towers in Utah to predict their seismic stability. They used mathematics that describe built structures' resonance to create a dataset, allowing for predictions without climbing the towers.
A team of scientists has developed a three-dimensional airway model made from patient-derived stem cells to study COVID-19 infection. The model replicates the initial stages of infection and can be used to test potential antiviral drugs, with results showing that multi-ciliated airway cells are the primary entry point for the virus.
Researchers from Tel Aviv University have engineered 3D human spinal cord tissues and implanted them in lab models with long-term chronic paralysis, resulting in an 80% success rate in restoring walking abilities. The team aims to conduct clinical trials in human patients within a few years to make the treatment commercially available.
Researchers at the University of Massachusetts Amherst developed a physical model that yields unprecedented high-resolution look at slip rates of faults, determining likelihood of earthquakes. The study reveals fault lines in kitchen sinks can predict earthquake-causing forces.
Researchers at Harvard SEAS developed a new way to simulate tens of thousands of bubbles in foamy flows. This allows for predictive simulations in scales ranging from microfluidics to crashing waves, opening up possibilities for industrial applications such as food production and drug development.
Researchers at Brown University have developed a new laboratory test model to investigate fibrosis treatments without the use of animals. The model uses human cells and replicates not only the structure of human tissue but also its mechanics, enabling scientists to study the underlying mechanisms of fibrosis and test potential treatments.
Breakthrough research reveals Tuberous Sclerosis Complex arises from human-specific progenitor cells, explaining its pathology. Human-derived cerebral organoid models shed light on complex brain development and potential mechanisms for other diseases.
A new combined 3D modelling technique can accurately predict abnormal heart rhythms in patients with hypertrophic cardiomyopathy approximately 80% of the time. The approach also identifies cardiac diffuse fibrosis as a risk factor for these abnormalities, potentially guiding patient care.
Researchers at Washington University in St. Louis described for the first time the structure of CcsBA, a protein that transports heme and attaches it to cytochromes. The study revealed two conformational states of CcsBA, allowing scientists to characterize the enzyme mechanism.
Researchers found that theropods strengthened their jaws through time, with expanding rear jaw portions and evolving different jaw shapes depending on diet. This allowed them to exploit a wider range of food items and minimized bone fracture risk.
A new study reveals that modern top-down climate-related factors combined with traditional bottom-up tectonic models can help uncover the history of the Andes Mountains. The research suggests that a submerged volcanic hotspot chain, known as the Juan Fernandez Ridge, plays a crucial role in shaping the Andes' unique tectonic setting.
Researchers have captured a 1,000-year-old supernova in 3D images, revealing unprecedented details about the elements ejected during a star's explosion. The study provides a three-dimensional map of these elements, shedding light on the conditions at the time of the explosion and the importance of asymmetries in supernovae.
Research reveals that captive animals on soft food diets may experience weaker skulls and reduced bite effectiveness when released back into the wild. The study found that rats fed softer diets had weaker skulls, but those switched from hard to soft food as juveniles also showed signs of weakened bone growth.
A new study uses deep learning to build three-dimensional models of protein interactions in eukaryotes, revealing hundreds of previously unknown complexes. This research has significant implications for understanding cellular processes and developing new medications for various health disorders.
Researchers developed a novel approach to study molecular fluctuations in one-dimensional shock waves, characterizing frequencies two orders of magnitude lower than those in boundary layer flow. The model correctly predicts fluctuations in high-speed vehicle shocks traveling at Mach 2-10.
Researchers uncover fossil remains of Issi saaneq, a long-necked herbivore that lived on Greenland during the Late Triassic Period. The discovery sheds light on the evolutionary pathways and timeline of sauropods, iconic land animals that existed for nearly 150 million years.
Researchers at LSU Health have rediscovered the correct anatomy of the hip muscles, finding that they do not join into a single tendon but instead attach to different regions. This discovery has significant implications for understanding the evolution of human upright gait and bipedal locomotion.
Theoretical physicists modelled the region around M87's supermassive black hole, confirming that gravity plays a key role in accelerating particles out to thousands of light years. The findings provide further evidence for Einstein's theory of general relativity and its application to astrophysical phenomena.
Researchers used 3D particle simulations to model energetic-particle radiation, which could aid in protecting space assets. The study revealed underlying mechanisms controlling particle acceleration during magnetic reconnection events.
Researchers at Arizona State University have refined cryogenic electron microscopy to produce more accurate structures of biological samples. The new method uses a statistical approach to model transitory structures, which can play a vital role in biological processes.
Researchers from DGIST propose an advanced network architecture that combines software-defined networks (SDN) and network function virtualization (NFV) to overcome the drawbacks of traditional networks. The proposed system can fine-tune processing resources, support dynamic service chaining, and improve performance and security.
Researchers developed a novel approach to 3D image segmentation, segmenting the gaps between parts instead of contours, to automate tedious tasks. The technique demonstrates promising results in diagnosing TMJ-related issues and has potential applications in other fields.
Researchers say the July 2021 flood in western Germany was more destructive than predicted, with mobilization of dead wood and sediment contributing to its impact. The event highlights the need for science to better understand precipitation-induced floods and their associated self-reinforcing effects.
Researchers at Nanyang Technological University have developed a 3D model of the human artery blood vessel wall to study atherosclerosis. The model, called an 'arterial wall-on-a-chip', helps understand how cholesterol and inflammatory cells contribute to the disease.
Researchers used quantum computers to study polymer models by recasting them as optimization problems, exploiting the machine's efficiency in solving such tasks. This approach enables harnessing the potential of quantum machines in a hitherto unexplored context.
A CT scan of an ancient reptile skull found nearly identical to one from much older elasmosaurids, indicating minimal evolutionary change over 22 million years. The discovery challenges the notion that such species would undergo significant changes in their morphology over extended periods.
A study on Homo floresiensis found its bite could exert around 1300 Newtons of force, comparable to modern humans and some extinct cousins. This suggests that the Hobbit might have been at greater risk of facial bone strain or dislocation when biting hard foods.
Researchers from FAU Harbor Branch adapted Structure-from-Motion photogrammetry to generate 3D models for tracking lesion progression and impacts on diseased coral colonies. The study found that stony coral tissue loss disease prevalence varied significantly across location, but not through time.
A new study on bats reveals that their brain's GPS system represents three-dimensional space in a unique way, with grid cells packed like spheres rather than circles. The researchers found that this arrangement allows for local order but lacks global symmetry.
Researchers have developed a neural network model called BiteNetPp to detect protein-peptide binding sites, enabling the design of peptide-based drugs. The model consistently outperforms existing methods and can analyze a single protein structure in under a second, making it suitable for large-scale studies.
Researchers at Oak Ridge National Laboratory are advancing various technologies to minimize oil leaks, enable 3D printing in space, and increase fuel efficiency from ethanol. They have developed a quantum sensing system to detect pipeline leaks more quickly, built a thermal protection shield for a capsule launched into space, and creat...
The June edition of SLAS Technology features protocols for controlled cell seeding, splitting and expansion of human fibroblasts, induced pluripotent stem cells, and neural progenitor cells. Researchers have made significant improvements in forming complex 3D structures but face challenges in automating assay protocols.
A breakthrough study uses oral tactile visualization of complex 3D structures to improve accessibility in STEM education for blind and visually impaired students. Students recognized structures by mouth at 85.59% accuracy, similar to recognition by eyesight using computer animation.
Geophysicists at St. Petersburg State University have developed an algorithm to combine electrical resistivity tomography (ERT) and radiomagnetotelluric (RMT) methods for more accurate subsurface imaging. The joint inversion of CSRMT and ERT data provides a closer match to borehole data, improving the accuracy of geophysical exploration.
Researchers have developed a 3D model using patient cells to simulate the disease, enabling fast and cost-effective testing of drugs. The model has validated the effectiveness of previously tested drugs, opening new avenues for finding personalized treatments.
Researchers developed a 3D 'lung-on-a-chip' model to study COVID-19's effects on cells and develop new treatments. The model replicates human alveolar lung tissue, allowing scientists to investigate how various therapies impact viral spread and test potential treatments.
Researchers are using 3D printed models to study ground motion after earthquakes, providing a novel platform for seismic experiments. The models replicate complex topographical features and allow scientists to simulate how seismic waves interact with the Earth's surface.
A new study examines the impact of augmented reality on retail sales. Researchers found that AR enhances product evaluation, reduces customer uncertainty, and promotes online channel adoption. The technology also benefits niche brands and premium products, leading to increased revenues for retailers.
Researchers designed and tested 3D printed beetle models to study mate choice in insects. The results show that the models are effective in simulating real behavior, with males preferring chemical signals and color cues over 2D counterparts.
Researchers have created the first in-vitro patient-derived 3D organoid models of nasopharyngeal cancer, enabling them to predict optimal radiation treatment doses. These models mimic the hypoxic radioresistant sub-volumes of recurrent NPC and have shown that radiation dose escalation can improve treatment outcomes.
Researchers successfully produced an artificial lung model with a three-layer structure of about 10 micrometers thickness using inkjet bioprinting. The model replicated the physiological response to viral infectivity and antiviral response, enabling mass production and quality control for disease models.
Researchers investigated how observers perform in 2D and 3D image localization tasks, finding that they often treat volumetric images as stacks of independent 2D images. This leads to inefficiencies in target localization, especially for smaller targets in 3D images.
Researchers developed a new analysis system to study brain function and diseases using 3D artificial brain models. The system allows for precise non-destructive stimuli and real-time measurement of neural signals, providing insights into functional connections between brain cells.
NYUAD researchers have developed a new technology that enables the creation of high throughput arrays of miniaturized 3D tumor models, which can be safely cryopreserved and stored for on-demand drug testing use. This technology has the potential to revolutionize personalized medicine by predicting the outcomes of drug efficacy.
Researchers from Skoltech and Russian Academy of Sciences have surveyed the newest known 30-meter deep gas blowout crater on the Yamal Peninsula, forming a 3D model to study its structure and composition. The 3D model reveals a unique underground cavity with an elliptical shape and a circular dome, providing clues about the crater's en...
A new machine-learning algorithm reveals multiple possible conformations of proteins that can be determined experimentally using cryo-electron microscopy. The researchers used this technique to study ribosome assembly and identified a new ribosomal state, as well as visualized large-scale flexible motions of the spliceosome.
Researchers have made breakthroughs in engineering models of tumors to expand cancer immunotherapy's effectiveness. By modifying the cells in a patient's immune system, scientists aim to target cold or non-inflamed tumors.