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DNA ‘barcodes’ help NUS researchers pinpoint gold nanoparticles that can strike cancer at its power source

The study uses DNA barcodes to track and compare dozens of gold nanoparticle designs in living tumour models, identifying those effective at reaching mitochondria. Two formulations emerged as standout performers, achieving high tumour regression when combined with RNA therapy and photothermal treatment.

SourceNational University of Singapore·JournalAdvanced Materials·DateMay 11, 2026

Pioneering new technique to barcode cells

Scientists have developed a pioneering new technique to barcode individual cells more accurately and efficiently. The method combines artificial intelligence with microfluidics, allowing for real-time analysis of single cells and enabling the efficient sorting and counting of cells.

SourceUniversity of Exeter·JournalAdvanced Materials Technologies·DateDec 17, 2021

Diagramming the brain with colorful connections

Scientists at Cold Spring Harbor Laboratory have created a new tool called BARseq2 that uses genetic tags to label brain cells and trace thousands of brain circuits simultaneously. This allows researchers to examine the complex interactions between neurons, enabling a better understanding of brain function and behavior.

SourceCold Spring Harbor Laboratory·JournalNature Neuroscience·DateMay 10, 2021

Dynamic photonic barcodes record energy transfer at the biointerface

Researchers developed bioresponsive dynamic barcodes using cavity-enhanced radiative energy transfer, converting biomolecular information into distinctive photonic barcodes. The system can detect molecules in a droplet with improved signal-to-noise ratio, enabling real-time intermolecular interaction and biosensing applications.

Genetic barcodes can ensure authentic DNA fingerprints

Researchers propose genetic barcodes to guarantee DNA samples' authenticity before reaching the lab, mitigating cyberbiosecurity threats. The system introduces non-harmful material into samples as they're collected, which acts as a password ensuring their genuineness upon processing.

SourceDuke University·JournalIEEE Transactions on Information Forensics and Security·DateMay 21, 2020

Structual color barcode micromotors for multiplex biosensing

Researchers at Southeast University have developed a novel kind of microtort with stable structural color for multiplex assays. These micromotors can efficiently accelerate mixing speed and increase probe-target interactions, leading to faster and more sensitive detection. The unique structural color coding allows for simultaneous mult...

SourceScience China Press·JournalNational Science Review·DateJan 16, 2020

Natural ingredients in supplements, nutraceuticals get a new type of barcode

A team of researchers has developed a method to authenticate botanical ingredients by assigning unique chemical barcodes, which can distinguish between different parts of the same plant and detect chemical contaminants. The new barcode system uses nuclear magnetic resonance and statistical analysis to group similar samples together.

SourceAmerican Chemical Society·JournalJournal of Agricultural and Food Chemistry·DateJun 26, 2019

Tiny light-up barcodes identify molecules by their twinkling

Researchers have developed a technique using time signals 'temporal barcodes' that can label molecules with distinct flashing patterns. This allows for the detection and identification of any number of molecules, including proteins, at the molecular scale, increasing efficiency and reducing costs compared to traditional methods.

SourceDuke University·JournalACS Synthetic Biology·DateApr 12, 2019

Making a map of the brain

Researchers have created a groundbreaking cellular atlas of the brain, revealing over 70 different types of neurons, their locations, and functions. This breakthrough technology allows for unprecedented insights into brain organization and behavior.

SourceHarvard University·JournalScience·DateNov 1, 2018

Recording every cell's history in real-time with evolving genetic barcodes

Researchers develop a method to continuously record cells' development using genetic barcodes, allowing them to trace the full developmental lineage of every mature cell. This breakthrough resolves longstanding questions about brain patterning and promises to exponentially increase understanding of cellular growth and disease emergence.

Democratizing single-cell analysis

Scientists at Allen Institute and University of Washington developed scalable SPLiT-seq method to characterize RNA in individual cells, enabling identification of various cell types in the brain. The technique significantly lowers the cost barrier for labs that want to perform single-cell profiling.

SourceAllen Institute·JournalScience·DateMar 15, 2018

Food or fraud?

Italian scientists introduce NanoTracer, a simplified assay combining DNA barcoding with nanotechnology to authenticate food with the naked eye. The test detects substitutes and adulterants in products like European perch and saffron powder.

SourceWiley·JournalAngewandte Chemie International Edition·DateJun 14, 2017

Fighting forgery with paper fingerprints

Researchers from Newcastle University have found an inexpensive and easy way to validate the authenticity of ANY paper document by taking a picture with a standard camera. The unique 'texture' fingerprint for every sheet of paper can be identified and verified with 100% accuracy, making it highly reliable even under rough handling.

SourceNewcastle University·JournalACM Transactions on Information and System Security·DateMay 24, 2017

Barcodes show the blood family tree

Scientists at Lund University have developed a barcode system to track the development of immune cells, revealing that stem cells undergo different stages of maturation. This discovery has significant implications for understanding leukemia and autoimmune diseases.

SourceLund University·JournalImmunity·DateAug 24, 2016

DNA barcodes gone wild

A team of researchers has developed a new technology that can stitch together DNA barcodes inside cells, allowing scientists to search amongst millions of protein pairs for protein interactions. This breakthrough increases the rate of discovery without increasing costs.

SourceUniversity of Toronto·JournalMolecular Systems Biology·DateApr 22, 2016

Illuminating the broad spectrum of disease

Researchers developed a new method called PRISM to test potential drug compounds on cancer and other cell lines simultaneously, allowing for pooling and testing of multiple cell lines. This approach promises to accelerate the search for targeted therapies by better representing the broad genetic diversity of disease.

SourceBroad Institute of MIT and Harvard·JournalNature Biotechnology·DateFeb 29, 2016

Unknown midge mystery solved

Researchers uncover hidden diversity in minute midges through DNA analysis and type material examination. Two new species were discovered and one misidentified species was corrected, shedding light on the fascinating world of non-biting midges.

SourcePensoft Publishers·JournalZooKeys·DateJun 18, 2015

Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems

A recent study leveraged BOLD specimen data to uncover new records of locality, provinces, territories, and states for Nearctic species of Microgastrinae wasps. The novel workflow enables researchers to utilize the vast amount of data stored on BOLD platforms, accelerating publication and dissemination of biodiversity-related research.

SourcePensoft Publishers·JournalBiodiversity Data Journal·DateOct 29, 2014

Scientists devise a bar code for the bacteria that causes tuberculosis

Researchers have devised a genetic barcode that can identify different types of tuberculosis (TB) bacteria, allowing doctors to track the spread of the disease more effectively. The study found that just 62 mutations are needed to code the global family of strains, making it easier for scientists to map how TB moves around the world.

SourceLondon School of Hygiene & Tropical Medicine·JournalNature Communications·DateSep 1, 2014

Family trees for yeast cells

Researchers have developed a new method to analyse the genomes of yeast families, which is several hundred times faster than current methods. The new method uses barcode-enabled sequencing and allows for the analysis of tetrad relationships between spores, enabling the study of complex traits.

SourceUniversity of Luxembourg·JournalNature Methods·DateMay 13, 2013