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Targeting unsuspected protein reverses lymphedema

A Cornell-led collaboration created a 3D in-vitro model of human lymphatic vessels that revealed a surprising mechanism jamming up drainage: the protein ROCK2. Inhibiting ROCK2 reverses lymphedema effects, offering potential treatment for this condition.

SourceCornell University·JournalProceedings of the National Academy of Sciences·DateOct 3, 2023

Dartmouth study removes human bias from debate over dinosaurs' demise

A new modeling method powered by interconnected processors removed human bias from the debate over dinosaurs' demise. The study suggests that the outpouring of climate-altering gases from the Deccan Traps alone could have been sufficient to trigger global extinction, consistent with volcanic eruptions contributing to the mass extinction.

SourceDartmouth College·JournalScience·TypeComputational simulation/modeling·DateSep 28, 2023

Study explains role of certain types of oxide in structure and development of specialty glass

Researchers found that adding niobium oxide to silicate glass increases bond density and connectivity, enhancing mechanical and thermal stability. This discovery could lead to the development of innovative glass formulations for various applications, including optics, medicine, and data transmission.

Hot Jupiter blows its top

Researchers used 3D simulations on Stampede2 to model the flow of HAT-P-32b's atmosphere, revealing a gigantic helium gas tail. The planet is losing significant atmospheric mass, which could help explain the mystery of intermediate-mass planets.

SourceUniversity of Texas at Austin·JournalScience Advances·TypeComputational simulation/modeling·DateSep 1, 2023

Neural network helps design brand new proteins

Researchers have developed a novel neural network approach to design brand new proteins with unique arrangements and dynamic functionalities. The method combines attention neural networks with graph neural networks to predict existing protein properties and envision new proteins that nature has not yet devised.

SourceAmerican Institute of Physics·JournalJournal of Applied Physics·DateAug 29, 2023

New methodology combines earthquake ground shaking and ground failure for forecasting gas pipeline damage

A new methodology, developed by USGS researchers, integrates earthquake-induced ground failures with ground shaking hazards to provide a comprehensive forecast for pipeline damage. This approach is crucial for identifying potential damage in buried gas pipelines covering hundreds of kilometers.

SourceSeismological Society of America·JournalBulletin of the Seismological Society of America·TypeComputational simulation/modeling·DateAug 24, 2023

AI models are powerful, but are they biologically plausible?

Researchers propose a hypothesis that astrocytes, non-neuronal cells in the brain, can perform core computation as transformers, providing insights into human brain function and machine learning success. This discovery could spark future neuroscience research and help explain transformer performance across complex tasks.

SourceMassachusetts Institute of Technology·JournalProceedings of the National Academy of Sciences·DateAug 15, 2023

Government regulation can effectively curb social media dangers

A study published in PNAS found that government-mandated external moderation is likely to be effective in limiting harm on fast-paced platforms like X. The researchers examined the dynamics of content dissemination and found that a lower half-life means most harm happens right after content is posted.

SourceUniversity of Technology Sydney·JournalProceedings of the National Academy of Sciences·TypeData/statistical analysis·DateAug 14, 2023

Bear-human coexistence rethought

A new study by Paula Mayer proposes a practical tool for identifying areas of high human-bear conflict in the Abruzzo region. The model considers factors such as habitat suitability, migration corridors, and human-made food resources to inform local measures promoting coexistence.

SourceETH Zurich·JournalJournal for Nature Conservation·TypeComputational simulation/modeling·DateAug 14, 2023

Mathematical theory predicts self-organized learning in real neurons

Researchers used a mathematical theory called the free energy principle to predict how real neural networks learn and organize themselves. The study successfully mimicked this process in rat embryo neurons grown in a culture dish, demonstrating the principle's guiding force behind biological neural network learning.

SourceRIKEN·JournalNature Communications·DateAug 7, 2023

Introducing GOBI: A breakthrough computational package for inferring causal interactions in complex systems

GOBI overcomes model-free and model-based inference method limitations by introducing an easily testable condition for a general monotonic ODE model to reproduce time-series data. It successfully infers positive and negative regulations in various networks, distinguishing between direct and indirect causation.

SourceInstitute for Basic Science·JournalNature Communications·TypeMeta-analysis·DateJul 24, 2023

Development of a ”network slicing” technique applicable to 6G core technology ”low-earth orbit (LEO) satellite communications”

The study proposes a novel network slicing planning and handover technique applicable to next-generation low-earth orbit (LEO) satellite networks. The developed technique can provide flexible services according to user needs, enabling the adoption of 6G-era demands such as VR/AR and autonomous driving.

SourceDGIST (Daegu Gyeongbuk Institute of Science and Technology)·JournalIEEE Vehicular Technology Magazine·DateJul 4, 2023

The Ising on the cake

A team of researchers from Kyoto University and international institutions has developed a mathematical solution to the temporal asymmetry of nonequilibrium disordered Ising networks. This breakthrough offers insights into the behavior of biological systems, machine learning, and AI tools.

SourceKyoto University·JournalNature Communications·TypeComputational simulation/modeling·DateJul 4, 2023

New understanding of why kidney cancers become metastatic discovered by MD Anderson researchers

Researchers at MD Anderson Cancer Center have engineered a new model of aggressive renal cell carcinoma, highlighting molecular targets and genomic events that trigger chromosomal instability. The loss of interferon receptor genes plays a pivotal role in allowing cancer cells to become tolerant of chromosomal instability.

Bridging traditional economics and econophysics

Researchers from Complexity Science Hub highlight similarities in models used by economists and physicists to analyze financial markets. The study aims to create an overview of these models, promoting interdisciplinary collaboration and avoiding research that gets lost in translation.

SourceComplexity Science Hub·JournalJournal of Economic Interaction and Coordination·TypeSystematic review·DateJun 19, 2023

Indirect effects of the Russia-Ukraine conflict revealed: global food supply at risk

A recent study by the Complexity Science Hub reveals interdependencies in the global food supply chain, uncovering profound indirect effects of the Russia-Ukraine conflict on product availability worldwide. The study found that indirect effects often exceeded direct effects, with losses up to 85% in maize and 89% in edible oils.

SourceComplexity Science Hub·JournalNature Food·TypeComputational simulation/modeling·DateJun 15, 2023

Geisel study offers new insights into how Medicare fraud has spread across U.S. regions in recent years

A study by Dartmouth's Geisel School of Medicine found that Medicare fraud in home healthcare billing spread rapidly across U.S. regions between 2002 and 2009, driven by characteristics such as shared patients, high expenditures, and rapid growth in the number of home health agencies. The researchers developed a novel network analysis ...

SourceThe Geisel School of Medicine at Dartmouth·JournalSocial Science & Medicine·TypeData/statistical analysis·DateJun 8, 2023

Networks in the dog brain

A recent study on canine brain networks has provided insights into the evolution of human brain function, revealing that the cingulate cortex played a central role in mammalian brain development. The research used fMRI to analyze brain activity in dogs and identified functional networks that differ from those in humans.

SourceEötvös Loránd University·JournalBrain Structure and Function·DateMay 26, 2023

Quotas alone will not solve the problem

A new study by the Complexity Science Hub recommends aligning quotas with an inclusive culture to improve women's representation in science. The research finds that even extreme quotas are not sufficient to increase minorities' visibility in top ranks, highlighting the need for behavioral interventions and regulation to overcome biases.

SourceComplexity Science Hub·JournalCommunications Physics·TypeComputational simulation/modeling·DateMay 25, 2023

GAME-Net: a graph neural network for fast evaluation of the adsorption energy in heterogeneous catalysis

Researchers developed GAME-Net, a graph neural network that rapidly evaluates adsorption energy for large molecules like plastics and biomass. The model achieves accuracy comparable to density functional theory (DFT) while utilizing simple molecular representations.

SourceInstitute of Chemical Research of Catalonia (ICIQ)·JournalNature Computational Science·TypeComputational simulation/modeling·DateMay 2, 2023

Can jack-of-all-trades AI reshape medicine?

Researchers chart course for generalist medical AI, capable of performing complex tasks in a wide range of scenarios. The model can integrate multiple data types and apply existing knowledge to new contexts, offering comprehensive solutions to alleviate clinician burnout and reduce clinical errors.

SourceHarvard Medical School·JournalNature·TypeCommentary/editorial·DateApr 26, 2023

Computational ‘short cuts’ offer fast answers to complex supply chain problems

Computational heuristics like Grey Wolf Optimizer and Whale Optimization Algorithm offer fast solutions to complex supply chain problems, providing accurate results within a shorter time frame. The research suggests these tools can be a valuable addition to supply chain management, especially in responding to unexpected disruptions.

SourceNorth Carolina State University·JournalIEEE Access·TypeComputational simulation/modeling·DateApr 25, 2023

Harnessing incoherence to make sense of real-world networks

A new approach to describing network connections can help predict system strong and weak points, crucial for understanding disease spread and communication networks. Researchers found that mapping hierarchies and incoherence within a system enables prediction of strong and weak connections.

SourceUniversity of Birmingham·JournalProceedings of the National Academy of Sciences·TypeComputational simulation/modeling·DateMar 20, 2023

AI offers ‘paradigm shift’ in Stanford study of brain injury

Researchers at Stanford University have developed a novel AI-powered approach to analyzing traumatic brain injury, using artificial intelligence to identify the most accurate model of mechanical stress on the brain. This breakthrough could lead to better understanding of when concussions lead to lasting brain damage and inspire new pro...

SourceStanford University School of Engineering·JournalActa Biomaterialia·TypeComputational simulation/modeling·DateMar 2, 2023